&lt;p&gt;Siva 1 Inhibits Cervical Cancer Progression and Its Clinical Prognosis Significance&lt;/p&gt;

Liu, Ting; Ma, Yihui; Wang, Zhong Lin; Zhang, Wenjing; Yang, Xinggang

doi:10.2147/cmar.s232994

Cited by 6 publications

(13 citation statements)

References 23 publications

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“…We found that TP53 activation of the target genes is substantially different among the four profiled regions of the tumor. The negative correlation of TP53 and SIVA1 in both normal tissue and the primary tumor “A” ( Figure S2a ), suggests that increased expression of SIVA1 is reported to inhibit cervical cancer progression [ 106 ] (and hopefully also the progression of prostate cancer) may be achieved by down-regulating TP53. This possibility is based on our “see-saw” model [ 107 ] indicating that similar effects of the increase of one gene expression can be obtained either by up-regulating another gene with a similar coordination profile (the ordered set of Pearson correlation coefficients between the expression levels of that gene with each other gene) or by down-regulating one with opposite coordination.…”

Section: Discussionmentioning

confidence: 99%

A Personalized Genomics Approach of the Prostate Cancer

Iacobaş

2021

Cells

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Decades of research identified genomic similarities among prostate cancer patients and proposed general solutions for diagnostic and treatments. However, each human is a dynamic unique with never repeatable transcriptomic topology and no gene therapy is good for everybody. Therefore, we propose the Genomic Fabric Paradigm (GFP) as a personalized alternative to the biomarkers approach. Here, GFP is applied to three (one primary—“A”, and two secondary—“B” & “C”) cancer nodules and the surrounding normal tissue (“N”) from a surgically removed prostate tumor. GFP proved for the first time that, in addition to the expression levels, cancer alters also the cellular control of the gene expression fluctuations and remodels their networking. Substantial differences among the profiled regions were found in the pathways of P53-signaling, apoptosis, prostate cancer, block of differentiation, evading apoptosis, immortality, insensitivity to anti-growth signals, proliferation, resistance to chemotherapy, and sustained angiogenesis. ENTPD2, AP5M1 BAIAP2L1, and TOR1A were identified as the master regulators of the “A”, “B”, “C”, and “N” regions, and potential consequences of ENTPD2 manipulation were analyzed. The study shows that GFP can fully characterize the transcriptomic complexity of a heterogeneous prostate tumor and identify the most influential genes in each cancer nodule.

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Section: Discussionmentioning

confidence: 99%

A Personalized Genomics Approach of the Prostate Cancer

Iacobaş

2021

Cells

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“…For example, Siva-1 is downregulated in colorectal cancer and breast cancer (27)(28)(29), but as an important regulator of apoptosis and metastasis, Siva-1 is also highly expressed and facilitates tumorigenesis in a number of malignant tumors, including ovarian cancer (30), osteosarcoma (18), non-small cell lung cancer (17) and gastric cancer (29). Although Siva-1 was initially identified as a promoter of apoptosis (7), the underlying molecular mechanism requires further investigation. The results of the present study indicated that Siva-1 overexpression inhibited apoptosis and enhanced multidrug resistance.…”

Section: Discussionmentioning

confidence: 99%

“…no. oP-0002; epiGentek Group, inc.), 1x10 7 cells were transferred to a 1.5-ml microcentrifuge tube and centrifuged at 500 x g at 4˚C for 3 min to harvest the cell pellet. ice-cold cytoplasmic extraction reagent was added, and the microcentrifuge tubes were left to incubate on ice for 1 min.…”

Section: Measurement Of Dox Pump Rate Via Flow Cytometrymentioning

confidence: 99%

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Siva‑1 regulates multidrug resistance of gastric cancer by targeting MDR1 and MRP1 via the NF‑κB pathway

Kong

Deng

et al. 2020

Mol Med Rep

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Siva-1 is a well-known anti-apoptosis protein that serves a role in multiple types of cancer cells. However, whether Siva-1 affects multidrug resistance via the nF-κB pathway in gastric cancer is currently unknown. The present study aimed to determine the possible involvement of Siva-1 in gastric cancer anticancer drug resistance in vitro. a vincristine (Vcr)-resistant KaTo iii/Vcr gastric cancer cell line with stable Siva-1 overexpression was established. The protein expression levels of Siva-1, nF-κB, multidrug resistance 1 (Mdr1) and multidrug resistance protein 1 (MrP1) were detected via western blotting. The effect of Siva-1 overexpression on anticancer drug resistance was assessed by measuring the 50% inhibitory concentration of KATO III/VCR cells to VCR, 5-fluorouracil and doxorubicin. The rate of doxorubicin efflux and apoptosis were detected by flow cytometry. additionally, colony formation, wound healing and Transwell assays were used to detect the proliferation, migration and invasion of cells, respectively. The results of the current study revealed that the Siva-1-overexpressed KATO III/VCR gastric cancer cells exhibited a significantly decreased sensitivity to VCR, 5-fluorouracil and doxorubicin. The results of flow cytometry revealed that the percentage of apoptotic cells decreased following overexpression of Siva-1. The colony formation assay demonstrated that cell growth and proliferation were significantly promoted by Siva-1 overexpression. additionally, Siva-1 overexpression increased the migration and invasion of KaTo iii/Vcr cells in vitro. Western blot analysis determined that Siva-1 overexpression increased nF-κB, Mdr1 and MrP1 levels. The current study demonstrated that overexpression of Siva-1, which functions as a regulator of Mdr1 and MrP1 gene expression in gastric cancer cells via promotion of nF-κB expression, inhibited the sensitivity of gastric cancer cells to certain chemotherapies. These data provided novel insight into the molecular mechanisms of gastric cancer, and may be of significance for the clinical diagnosis and therapy of patients with gastric cancer.

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“…Beyond its role in apoptosis, SIVA-1 also regulates other cellular processes, such as cellular migration ( Li et al, 2011 ; Ma et al, 2017 ), autophagy ( Van Nostrand et al, 2015 ), and proliferation ( Ma et al, 2017 ; Liu et al, 2020 ). In cancer studies SIVA-1 has been found to have a role as pro- or anti-malignant factor, depending on cellular context ( Vachtenheim et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function

Coccia

Solé

Comella

2022

Front. Cell Dev. Biol.

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Apoptosis is crucial for the correct development of the nervous system. In adulthood, the same protein machinery involved in programmed cell death can control neuronal adaptiveness through modulation of synaptic pruning and synaptic plasticity processes. Caspases are the main executioners in these molecular pathways, and their strict regulation is essential to perform neuronal remodeling preserving cell survival. FAIM-L and SIVA-1 are regulators of caspase activation. In this review we will focus on FAIM-L and SIVA-1 as two functional antagonists that modulate non-apoptotic caspase activity in neurons. Their participation in long-term depression and neurite pruning will be described in base of the latest studies performed. In addition, the association of FAIM-L non-apoptotic functions with the neurodegeneration process will be reviewed.

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<p>Siva 1 Inhibits Cervical Cancer Progression and Its Clinical Prognosis Significance</p>

Cited by 6 publications

References 23 publications

A Personalized Genomics Approach of the Prostate Cancer

A Personalized Genomics Approach of the Prostate Cancer

Siva‑1 regulates multidrug resistance of gastric cancer by targeting MDR1 and MRP1 via the NF‑κB pathway

FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function

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