<p>SNHG15: a promising cancer-related long noncoding RNA</p>

Abstract

Cancer is expected to rank as the leading cause of death worldwide due to increasing morbidity and mortality. Long noncoding RNAs (lncRNAs) have been found to play pivotal roles in multiple biological processes, such as transcriptional interference, posttranscriptional regulation and epigenetic modification. Small nucleolar RNA host gene 15 (SNHG15), a snoRNA host gene which produces a short half-lived lncRNA, was reported to be upregulated in tumor cells and participate in the occurrence and development of multiple cancers. And more than half of the SNHG15 research in cancers has been published within the last 2 years. In this review, we summarized the current evidence concerning the biological functions and molecular mechanisms of SNHG15 in various cancers, including gastric, hepatocellular, pancreatic, colorectal, breast, and thyroid cancer, osteosarcoma, glioma, lung cancer, renal cell carcinoma, and epithelial ovarian cancer. SNHG15 plays critical roles in regulation of cell proliferation, migration and invasion of tumors via different potential mechanisms. Moreover, the abnormal expression of SNHG15 was associated with clinical features of patients with cancers. Consequently, SNHG15 could be considered as a promising biomarker for cancer diagnosis, prognosis or treatment.

The multifaceted roles of long noncoding RNAs in pancreatic cancer: an update on what we know

“…Small nucleolar RNA host gene 15 (SNHG15) and 16 (SNHG16) are both significantly increased in PC cells [59]. The upregulation of SNHG15 is significantly associated with tumor size, lymph node metastasis, and advanced TNM stage in patients with PC.…”

“…The upregulation of SNHG15 is significantly associated with tumor size, lymph node metastasis, and advanced TNM stage in patients with PC. Functionally, the SNHG15 combination attenuates cell proliferation and simultaneously induces apoptosis and cell cycle arrest at the G0/G1 phase [59]. SNHG15 downregulates P15/KLF2 through EZH2-mediated H3K27me3, contributing to proliferation [60].…”

Linc01234 promotes cell proliferation and metastasis in oral squamous cell carcinoma via miR-433/PAK4 axis

“…In addition, aberrant lncRNAs also serve as prognostic indicators for tumor recurrence and metastasis. For example, SNHG15 was reported to be significantly upregulated in tumors and enhanced SNHG15 expression could be a promising biomarker for cancer diagnosis, prognosis or treatment [9]. However, the detailed biological importance of most lncRNAs in OSCC development remains unclear.…”

Supervised and Unsupervised Classification of lncRNA Subtypes

“…[8][9][10][11][12][13] and the references therein. SNHG15, for instance, is dysregulated in a wide variety of cancers and interacts with several distinct molecular pathways apparently using different molecular mechanisms, reviewed in [10]. Similar, there are several competing, not mutually exclusive, mechanistic explanations for the function of GAS5 [8].…”