&lt;p&gt;State of the art for gastric signet ring cell carcinoma: from classification, prognosis, and genomic characteristics to specified treatments&lt;/p&gt;

Machlowska, Julita; Pucułek, Małgorzata; Sitarz, Monika; Terlecki, Paweł; Maciejewski, Ryszard; Sitarz, Robert

doi:10.2147/cmar.s188622

Cited by 55 publications

(76 citation statements)

References 75 publications

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“…This has evolved into the current dichotomy of diffuse gastric cancers: SRCCs and other poorly cohesive carcinomas. The two key pathogenic characteristics of SRCCs are their loss of cell-cell adhesion properties leading to their diffuse pattern of spread, and mucin accumulation [ 8 ]. It is not known if these two processes are connected.…”

Section: Discussionmentioning

confidence: 99%

“…The WHO formalized the definition of SRCCs as a histological subtype in gastric cancer in 1990 [ 8 , 25 ]. On the basis of jointpoint analysis (Jointpoint Trend Analysis Software, Version 4.8.0.1, Surveillance Research Program, National Cancer Institute, Calverton, MD, USA) completed on age-adjusted yearly incidence rates from 1975–2016, cases prior to 1992 were excluded assuming SRCCs were more likely to be diagnosed as adenocarcinomas prior to increased recognition of SRCCs as a distinct histological subtype in 1990 ( Figure S1 ).…”

Section: Methodsmentioning

confidence: 99%

“…The systematic study of these cancers is limited due to the rarity of this histological diagnosis. For gastric cancers, the World Health Organization (WHO) classification lists SRCCs under the category of diffuse or poorly cohesive carcinomas, which is divided into SRCCs and other poorly cohesive carcinomas [ 5 , 8 ]. For colorectal cancers, SRCCs are a recognized histological subtype of adenocarcinomas if they meet the definition as described previously [ 2 ].…”

Section: Introduction—overview Of Signet Ring Cell Adenocarcinomasmentioning

confidence: 99%

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Epidemiology of Signet Ring Cell Adenocarcinomas

Benesch

Mathieson

2020

Cancers

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Signet ring cell adenocarcinomas (SRCCs) are a rare histological subtype of adenocarcinomas with a poor prognosis, typically due to advanced disease at diagnosis. A signet ring cell, mimicking its moniker, contains abundant intracytoplasmic mucin that pushes the nucleus to the periphery. In these cancers, this cell feature comprises more than 50% of the tumor. Despite predilection for the gastrointestinal tract, and in particular the stomach, primary SRCCs are also described in other sites, typically in case reports. This literature, however, lacks a standardized overview of the SRCC disease entity. Using a retrospective cohort approach, we summarize the clinicodemographic and mortality outcomes of SRCCs in thirteen primary sites, comprising 95% of all SRCCs in the Surveillance, Epidemiology, and End Results Program (SEER), a population-level cancer database covering nearly one-third of the United States population. SRCCs general trends compared to matching nonvariant adenocarcinomas are earlier age of onset, with initial presentation favoring higher rates of regional or distant disease presentation and poor tumor differentiation. After multivariable analysis, SRCCs typically have worse overall survivals, but substantial variances exist depending on tumor location. Identifying SRCCs at earlier disease stages is likely the single most important intervention to improving outcomes for these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introduction—overview Of Signet Ring Cell Adenocarcinomasmentioning

confidence: 99%

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Epidemiology of Signet Ring Cell Adenocarcinomas

Benesch

Mathieson

2020

Cancers

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“…Pure Sig is usually present in the intramucosal layer, while its morphology is often lost during tumor growth and transformation into poorly cohesive carcinoma [17]. Sig can easily transform into poorly cohesive carcinoma in invasive areas and is most frequent in advanced gastric cancer [18]. Piessen et al demonstrated that Sig often developed peritoneal metastasis and lymph node invasion and would often fail R0 resection, and Sig was associated with a worse prognosis than non-Sig in a group matchedcontrolled study [19].…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of coexisting histological diffuse type in stage II/III gastric cancer: A retrospective study

Tanaka¹,

Yoshii²,

Miki³

et al. 2020

Preprint

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Background: Since 1965, the Laurén classification has been used most commonly for gastric adenocarcinoma, with two types, intestinal type and diffuse type. Signet ring cell carcinoma (Sig) and non-solid poorly differentiated adenocarcinoma (Por2) are the histological forms of diffuse type and are often found in advanced tumors, and they seem to be associated with a poor prognosis. S-1 based adjuvant chemotherapy for patients with stage II/III gastric cancer has generally been accepted in Japan, but histological type does not alter treatment strategy. The aim of the present study was to investigate the prognostic impact of the histopathologic mixture of Sig and Por2 in patients with stage II/III gastric cancer treated with S-1 adjuvant chemotherapy.Methods: The clinicopathological data of 968 gastric carcinoma patients who underwent gastrectomy between 2007 and 2016 at our department were retrospectively analyzed. In this study, tumors containing Sig or Por2 were classified as Diffuse type, and those not containing them were classified as Intestinal type.Results: There were 307 cases of Diffuse type and 661 of Intestinal type. Diffuse type included 189 cases with Sig. Pathological diagnosis of Sig was an independent risk factor for peritoneal recurrence in patients with stage II/III. Patients with Diffuse type had worse overall survival than those with Intestinal type in Stage III. Of the patients who received S-1 adjuvant chemotherapy, the prognosis of Stage III patients with Sig but not Por2 was Significantly worse compared to patients with Intestinal type.Conclusions: The coexistence of Signet ring cell carcinoma in the primary tumor was associated with a poor prognosis in patients with stage III gastric cancer. These findings suggest that, because mixed Sig gastric cancer had a high risk of peritoneal recurrence even if adjuvant chemotherapy were performed, the pathological diagnosis should be considered when determining the therapeutic strategy for adjuvant chemotherapy in stage III gastric cancer.

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“…GC ranks as the sixth most common newly diagnosed cancer, with an incidence of 5.7%; however, the mortality rate is as high as 8.2%, second only to mortality due to lung cancer (1). Although comprehensive treatment based on surgery in recent years has further improved the treatment of patients with GC, the overall prognosis of patients with GC is still poor (2,3). Therefore, it is particularly important to effectively predict the survival of patients with GC and to develop individualized treatment options.…”

Section: Introductionmentioning

confidence: 99%

Value of the preoperative prognostic nutritional index for the evaluation of patient prognosis after radical gastrectomy

et al. 2020

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Preoperative prognostic nutritional index (PNI) has been widely used for the clinical evaluation of patients with cancer. The present study assessed the prognostic value of preoperative PNI in patients after gastric cancer (GC) radical surgery. The clinical case and follow-up data of 170 patients undergoing GC radical surgery were retrospectively analyzed. The receiver operating characteristic (ROC) curve was used to compare the predictive ability of each inflammatory index: The PNI, neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR). The correlation between the preoperative PNI and overall survival (OS) was also analyzed via Kaplan-Meier (K-M) curves and multivariate Cox regression analyses. The results revealed that the optimal PNI cutoff was 46.030. According to this cutoff value, the whole sample was divided into PNI <46.030 (low PNI group) and PNI ≥46.030 (high PNI group). These groups were comprised of 102 and 68 cases, respectively. The area under the curve value of the PNI was 0.725, which was greater than that of traditional inflammatory indices, including the NLR and LMR. K-M survival analysis revealed that the 5 year survival rate of patients in the low PNI group was significantly lower than that of patients in the high PNI group (P<0.01). Univariate analysis and Cox multiple regression model analysis demonstrated that the T stage, N stage, pathological grade and PNI were independent risk factors for the 5 year survival rate after radical gastrectomy (P<0.05). In conclusion, the preoperative PNI is an independent risk factor for 5 year survival after radical gastrectomy and has clinical value for the prognostic evaluation of patients with GC.

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<p>State of the art for gastric signet ring cell carcinoma: from classification, prognosis, and genomic characteristics to specified treatments</p>

Cited by 55 publications

References 75 publications

Epidemiology of Signet Ring Cell Adenocarcinomas

Epidemiology of Signet Ring Cell Adenocarcinomas

Clinical Significance of coexisting histological diffuse type in stage II/III gastric cancer: A retrospective study

Value of the preoperative prognostic nutritional index for the evaluation of patient prognosis after radical gastrectomy

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