<p>Study on Risk Factors of Diabetic Nephropathy in Obese Patients with Type 2 Diabetes Mellitus</p>

Abstract

The purpose of this study was to identify diabetic nephropathy risk factors in type 2 diabetes mellitus obese people based on community type 2 diabetes mellitus patients. Patients and Methods: In the community in Shanghai, we conduct a questionnaire, physical examination, and biochemical examination. The 406 patients included in the analysis were divided into two groups based on whether or not they had diabetic nephropathy. The influencing factors of type 2 diabetes mellitus obese patients were screened by the least absolute shrinkage and selection operator method, and then the influencing factors detected by the least absolute shrinkage and selection operator method were included in the binary logistic regression analysis, and the risk factors for diabetic nephropathy in obese people with type 2 diabetes mellitus were obtained. Finally, the nomogram and forest plot are used to visualize the binary logistic regression results, and the calibration plot and receiveroperating characteristic curve are used to verify the result. Results: The results showed that family history of diabetes (OR= 2.091, P= 0.002), disease course (OR=1.050, P= 0.007). hypertension (OR=1.768, P=0.042), hyperuricemia (OR=2.263, P=0.003), systolic blood pressure (OR=1.027, P<0.001), and glycosylated haemoglobin A1c (OR=1.358, P<0.001) were risk factors for diabetic nephropathy. Conclusion: For obese patients with type 2 diabetes mellitus, they should pay attention to family history of diabetes, disease course and hyperuricemia. Hypertension should be concerned and strictly controlled. Systolic blood pressure and glycosylated haemoglobin A1c will help prolong the survival of diabetic nephropathy patients.

The interaction analysis between advanced age and longer dialysis vintage on the survival of patients receiving maintenance hemodialysis

“… 20 Consistent with this, reductions in systolic blood pressure and glycosylated hemoglobin A1c prolong the survival of patients with DN. 21 Thus, the management of blood pressure and blood glucose is essential for patients undergoing MHD.…”

Antidiabetic and Other Therapies Used in Subjects with Diabetes and Chronic Kidney Disease in a Hospital-Based Clinic Population in Greece

“…A previous publication from our team found a significant correlation of DCKD with retinopathy and peripheral neuropathy [ 2 ]. Therefore, in contrast to previous publications [ 32 , 33 , 39 , 61 ], a more holistic approach to the management of patients with DCKD is proposed by the present study, including not only the regulation of hyperglycemia but also that of BP and dyslipidemia. According to the recent American Diabetes Association Guidelines, when patients have an eGFR <30 mL/min/1.73 m 2 , they should be referred to a nephrologist [ 16 ].…”

“…We should note, however, that there may be a point beyond which further BP reduction may not be helpful or even be harmful despite a reduction in proteinuria. The current KDOQI guidelines recommend a goal of BP <130/80 mmHg, whereas the Eighth Joint National Committee (JNC8) guidelines recommend a goal of BP <140/90 mmHg for most patients with T2DM and diabetic nephropathy, but with individualization [ 3 , 57 , 58 , 59 , 60 , 61 ]. In our study, most participants (77%) had hypertension.…”

Hypertriglyceridemia and Other Risk Factors of Chronic Kidney Disease in Type 2 Diabetes: A Hospital-Based Clinic Population in Greece

“…In patients with DCKD, the optimal BP for minimizing the risk of DCKD progression and cardiovascular events is unclear [ 24 ]. Several guidelines recommend a goal of BP < 130/80 mm Hg and a BP < 140/90 mm Hg for most patients with T2DM and DCKD [ 25 , 26 ]. In a high percentage of subjects with T2DM, arterial hypertension is already present at the time of diagnosis [ 27 ].…”