&lt;p&gt;Subjective Comparison of Pre-Lens Tear Film Stability of Daily Disposable Contact Lenses Using Ring Mire Projection&lt;/p&gt;

Müller, Christiane; Marx, Sebastian; Wittekind, Julia; Sickenberger, Wolfgang

doi:10.2147/opto.s235167

Cited by 9 publications

(13 citation statements)

References 28 publications

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“…Muller et al attempted measuring tear film stability using NIK-DUT, which was a method based on the conventional NIKBUT technique. 34 NIK-DUT was recorded from the blink until the appearance of the first distortion of the ring mire by using a stopwatch and not automatic detection. They concluded that although NIK-DUT did not differ significantly among three types of silicone hydrogel SCLs, their subjective wettability grades differed significantly.…”

Section: Discussionmentioning

confidence: 99%

Comparison and Evaluation of Prelens Tear Film Stability by Different Noninvasive in vivo Methods

Itokawa

Suzuki

Iwashita

et al. 2020

OPTH

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Purpose Prelens tear film stability of soft contact lens (SCL) play an important role for contact lens discomfort. In this study, we investigated the association between two types of noninvasive methods and evaluated the tear film stability with SCL using the methods. Patients and Methods In experiment 1, images of ring mire were recorded with a keratograph after focusing the pigment located at the front or back of the SCL. Interferometry and videokeratoscopy were used for the assessment of tear film stability in the right eye of 10 women, with two different cosmetic daily disposable SCLs: polymacon and etafilcon A with polyvinylpyrrolidone. Time to first distortion by noninvasive keratograph break up time (NIKBUT-first) was compared to noninvasive interferometry break up time (NIBUT). In experiment 2, ten normal females wore two different daily disposable SCLs: samfilcon A and narafilcon A. NIKBUT-first and NIBUT were compared between the lenses after 8 hours of SCL wearing. Results In experiment 1, NIBUT-first without SCL was significantly correlated to NIBUT without SCL (r=0.445, P=0.0488, Pearson’s correlation coefficients). However, NIKBUT-first with SCL was not significantly correlated with NIBUT with SCL. In experiment 2, although NIKBUT-first was not significantly different between SCLs, samfilcon A had significantly longer NIBUT than narafilcon A (P=0.0315, paired t -test). Conclusion NIKBUT-first with SCL could be related to tear film stability between the lens and the corneal surface, but not to prelens tear film stability. NIIBUT could be a suitable method to evaluate prelens tear stability.

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Section: Discussionmentioning

confidence: 99%

Comparison and Evaluation of Prelens Tear Film Stability by Different Noninvasive in vivo Methods

Itokawa

Suzuki

Iwashita

et al. 2020

OPTH

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“…The comfort and vision results were reported previously. 38 There were no adverse events during the study.…”

Section: Resultsmentioning

confidence: 88%

“…Although subjective evaluation was able to determine the first noticeable ring distortion and grade wettability, this procedure is very time consuming in practice. 38 The objective approach may reduce the time necessary to evaluate the captured information. Future studies can evaluate new endpoints that better account for the dynamics of the pre lens tear film and that are not limited to a certain time point as in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…five different zones of the lens surface at different time points during the inter-blink period. 38 In contrast, the present study describes the results of software-supported analyses of the reflected ring mire, a more user independent approach of evaluating the performance of soft contact lens after 12 hours of wear.…”

mentioning

confidence: 98%

“…Compared with the fully subjective evaluation of the Placido rings reflected from the lens surface, 38 the objective approach uses a grid that centrally overlies the video. It allows software to highlight detected ring distortion as an indicator of the dewetting process.…”

mentioning

confidence: 99%

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Objective Analysis of Pre-Lens Tear Film Stability of Daily Disposable Contact Lenses Using Ring Mire Projection

Marx¹,

Wittekind²,

Sickenberger³

2020

OPTO

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Purpose: The primary objective of this study was to evaluate the in vivo pre-lens noninvasive drying-up time of two types of daily disposable contact lenses (DDCLs) after 12 hours of wear. Methods: This prospective, randomized, single-center, cross-over pilot study evaluated 31 subjects aged 18-44 years with normal eyes and good tear film stability who were adapted current soft contact lens wearers. Subjects wore nelfilcon A and stenfilcon A DDCLs for 12 hours each on two different days. Non-invasive video keratography drying-up time (NIK-DUT) videos of each eye were recorded 12 hours after lens insertion for about 25 seconds, with a 5-minute tear film recovery time allowed between video recordings of the right and left eyes to avoid bias. Post-blink time required to reach 15% distortion of the projected rings and the speed of break-up at 15 seconds post-blink were measured at each time point and oneye wettability was determined by ring mire projection under white light illumination. Results: Mean time to reach 15% ring distortion was similar for nelfilcon A (19.25±3.20 sec) and stenfilcon A (20.24±3.02 sec) DDCLs but varied highly among subjects. The mean speed of break-up at 15 sec post-blink was 0.3±0.38% distortion/sec (95% confidence interval [CI] 0.138-0.365% distortion/sec) for nelfilcon A and 0.2±0.23% distortion/sec (95% CI 0.048-0.279% distortion/sec) for stenfilcon A DDCLs. Conclusion: Multifunctional topography allowed the objective evaluation of in vivo prelens tear film stability using ring mire projection. This dynamic method was simple, fast and non-invasive, enabling measurements of NIK-DUT and evaluating wettability over a large area, greater than the optical zone of the contact lens surface, for the entire inter-blink interval.

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BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Willcox

Keir

Maseedupally

et al. 2021

Contact Lens and Anterior Eye

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Contact lens materials have undergone significant changes over the past 20 years, particularly with respect to the introduction of silicone hydrogel materials. Whilst this development addressed hypoxic issues, other important areas relating to contact lens success, notably comfort, require further research.Contact lens wettability remains a crucially important part of biocompatibility. Contact lenses can be made more wettable by incorporation of surfactants into blister packs, internal wetting agents, surface treatments or care solutions. However, there remains no clear association between contact lens wettability and comfort, making it challenging to determine the potential for these approaches to be of significant clinical benefit. Most contact lenses are used on a daily wear, reusable basis, which requires them to be disinfected when not worn. The ideal disinfecting solution would also improve comfort during wear. However, balancing these requirements with other factors, including biocompatibility, remains a challenge. Soft lens materials invariably take up and subsequently release certain components of disinfecting solutions onto the ocular surface. This may affect tear film stability and the normal ocular microbiome, and further research is needed in this area to determine whether this has any affect on comfort. Finally, contact lens materials sorb components of the tear film, and these interactions are complex and may change the biochemistry of the tear film, which in turn may affect their comfort.In conclusion, the interaction between lens materials, tear film and disinfection solution plays an important role in the biocompatibility of lenses. However, the exact role and whether this can be altered to improve biocompatibility and comfort during wear remains debatable. This report summarises the best available evidence to examine this complex relationship and the opportunities for practitioners to enhance in-eye comfort of contemporary lenses, along with providing suggestions for areas of study that may provide further information on this topic.

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<p>Subjective Comparison of Pre-Lens Tear Film Stability of Daily Disposable Contact Lenses Using Ring Mire Projection</p>

Cited by 9 publications

References 28 publications

<p>Comparison and Evaluation of Prelens Tear Film Stability by Different Noninvasive in vivo Methods</p>

<p>Comparison and Evaluation of Prelens Tear Film Stability by Different Noninvasive in vivo Methods</p>

<p>Objective Analysis of Pre-Lens Tear Film Stability of Daily Disposable Contact Lenses Using Ring Mire Projection</p>

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

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