&lt;p&gt;Synergistic Association of Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 on the Risk of Abnormal Glucose Regulation&lt;/p&gt;

Cheng, Yu-Cheng; Li, Yu-Hsuan; Hsu, Chiann‐Yi; Lee, I-Te

doi:10.2147/dmso.s256223

Cited by 6 publications

(8 citation statements)

References 64 publications

(70 reference statements)

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“…Multiple studies have found that the elevation of CEA occurred more frequently in patients with diabetes than in patients without diabetes, and the elevated CEA in diabetic patients was associated with HbA1c and reversible. 6,7,23 These results were consistent with our study results.…”

Section: Discussionsupporting

confidence: 93%

“…5 Studies showed that diabetic patients had significantly higher rates of abnormal tumor markers than those without diabetes, including carcinoembryonic antigen (CEA), carbohydrate antigens, neuron-specific enolase (NSE), and cytokeratin 19 fragment (CYFRA 21-1). [6][7][8] The relationship between diabetes and cancer is uncertain. However, tumor markers in diabetic patients are significantly elevated.…”

Section: Introductionmentioning

confidence: 99%

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The High Prevalence of Short-Term Elevation of Tumor Markers Due to Hyperglycemia in Diabetic Patients

Liu¹

2022

DMSO

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The relationship between diabetes and cancer is uncertain. However, tumor markers in diabetic patients are significantly elevated. The prevalence of diabetic inpatients with elevation of tumor markers and its relationship to blood glucose is needed to be studied. Methods: A total of 102 diabetic inpatients were included in this study. We collected information from diabetic inpatients and tested tumor markers. Patients with elevation of tumor markers were rechecked. Results: We found that up to 73.3% of diabetic inpatients had one or more tumor markers elevated. The proportion of diabetic inpatients with higher than normal cytokeratin 19 fragment (CYFRA 21-1) was 54.5%. Most of them did not return to normal after controlling the blood glucose. A short-term elevation of carcinoembryonic antigen (CEA) was present in 15.8% of diabetic inpatients, and 19.8% of diabetic inpatients had a short-term elevation of carbohydrate antigen. CEA and carbohydrate antigen including CA19-9, CA72-4, CA125 and CA15-3 returned to normal or became significantly reduced within 2 weeks after good control of blood glucose. Conclusion:Our study showed that the elevation of tumor markers was common in diabetic inpatients, especially those with poor blood glucose control. It indicated that re-checking the tumor markers after controlling blood glucose might be better than conducting large-scale test for cancer.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

The High Prevalence of Short-Term Elevation of Tumor Markers Due to Hyperglycemia in Diabetic Patients

Liu¹

2022

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“…6 However, it was showed that diabetic patients had significantly higher rates of elevated CEA than subjects without diabetes. [7][8][9] We found that there was a short-term elevation of CEA in diabetic inpatients, and there was a significant difference in HbA1c between the elevated CEA group and the group with normal CEA. 10 However, due to the insufficient number of patients, correlation analysis was not conducted in our last study.…”

Section: Introductionmentioning

confidence: 67%

High Prevalence of Abnormal Carcinoembryonic Antigen in Diabetic Inpatients with Poor Glycemic Control

Liu¹,

Jaturapitakkul²,

Zhou³

2022

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Introduction Higher serum carcinoembryonic antigen (CEA) was found in diabetic patients rather than controls. However, the prevalence of abnormal CEA among diabetic inpatients with a large proportion of poor glycemic control is unclear. Methods A total of 385 diabetic inpatients were included in this study. We collected information from a large clinical database. Patients with malignant tumors were excluded by examination and follow-up. Results We found a surprisingly high prevalence (14.3%) of diabetic inpatients with CEA above normal. The proportion of patients with abnormal CEA was significantly different in subgroups with different blood glucose levels, 20.4% in the HbA1c ≥ 9% group, and 8.5% in the HbA1c < 9%, p = 0.000. We found that the CEA levels were correlated with age, body mass index and HbA1c. The regression coefficient of HbA1c was the highest, B = 0.284, p = 0.000. We also found that the CEA levels were higher in diabetic inpatients with BMI < 24 kg/m2 than the overweight or obesity patients. There was a significant difference in the insulin level and C peptide level between the elevated CEA group and the non-elevated CEA group. Conclusion The elevation of CEA is common in diabetic inpatients, especially those with poor hyperglycemia controlled (HbA1c ≥ 9%). The underlying mechanism may be related to glucose toxicity.

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“…In a follow-up study, increased serum CEA may also account for the progression of coronavirus disease 2019 [ 27 ], more frequent fracture incidence [ 28 ], severity of heart failure (HF), HF adverse prognosis [ 29 ], CVD events and all-cause mortality [ 10 ]. Furthermore, elevated serum CEA may be an important risk factor for prediabetes and T2D [ 11 ], and the levels of serum CEA are closely associated with poor glycaemic control [ 30 ] and oxygen desaturation index [ 31 ] in patients with T2D. Regarding diabetic complications, higher serum CEA levels may independently contribute to macroalbuminuria in patients with diabetes [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Increased serum CEA levels are not only cross-sectionally associated with obesity, metabolic syndrome, and leukoaraiosis of the brain [7][8][9] but can also longitudinally predict cardiovascular events and mortality in the general population [10]. Additionally, serum CEA levels are increased in patients with prediabetes and type 2 diabetes (T2D) and are associated with diabetic complications, such as diabetic nephropathy [11,12]. Nevertheless, the relationship between serum CEA levels and DPN in T2D has not been well investigated.…”

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confidence: 99%

High-normal serum carcinoembryonic antigen levels and increased risk of diabetic peripheral neuropathy in type 2 diabetes

Wang

Zhuang

et al. 2022

Diabetol Metab Syndr

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Background Increased serum carcinoembryonic antigen (CEA) levels are reported to be associated with various metabolic and inflammatory diseases. This study assessed whether high-normal serum CEA is related to diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes (T2D). Methods All subjects received DPN assessment based on neuropathic symptoms, neuropathic signs, and nerve conduction studies to calculate composite Z scores of nerve latency, amplitude and conduction velocity (NCV). DPN was confirmed by both at least a presentation of neuropathic symptoms/signs and an abnormal nerve conduction index. Serum CEA levels and other clinical indices were also synchronously detected. Multivariable linear regression analyses were used to determine the independent effects of serum CEA levels on nerve conduction indices, multivariable logistic regression analyses were used to determine the independent impact of CEA levels on the risk of DPN, and receiver operating characteristic (ROC) curve analysis was used to assess the diagnostic capability of CEA levels to discriminate DPN. Results We ultimately recruited 402 eligible subjects with normal ranges of serum CEA for this study, and 25.4% (n = 102) were determined to have DPN. After adjusting for other clinical covariates, serum CEA levels were independently associated with the composite Z score for latency (β = 0.132, t = 2.330, p = 0.021), amplitude (β = − 0.164, t = − 2.838, p = 0.005) and NCV (β = − 0.210, t = − 3.662, p < 0.001). Moreover, the prevalence of DPN in the first, second, third and fourth quartiles of CEA level was 12.9%, 19.0%, 29.4% and 40.4%, respectively (p for trend < 0.001); the corresponding adjusted odds ratios and 95% CIs for DPN in CEA quartiles were 1, 1.47 (0.45–4.82), 1.72 (0.54–5.53) and 4.58 (1.39–15.06), respectively. Furthermore, the optimal cut-off value of high-normal serum CEA to discriminate DPN was ≥ 2.66 ng/mL, with a Youden index of 0.28, sensitivity of 66.67% and specificity of 61.00%. Conclusions Increased serum CEA levels within the normal range are closely linked to dysfunction of peripheral nerve conduction and the risk of DPN, and high-normal serum CEA levels are a potential risk factor for DPN in T2D.

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<p>Synergistic Association of Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 on the Risk of Abnormal Glucose Regulation</p>

Cited by 6 publications

References 64 publications

The High Prevalence of Short-Term Elevation of Tumor Markers Due to Hyperglycemia in Diabetic Patients

The High Prevalence of Short-Term Elevation of Tumor Markers Due to Hyperglycemia in Diabetic Patients

High Prevalence of Abnormal Carcinoembryonic Antigen in Diabetic Inpatients with Poor Glycemic Control

High-normal serum carcinoembryonic antigen levels and increased risk of diabetic peripheral neuropathy in type 2 diabetes

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