<p>Ta-Coated Titanium Surface With Superior Bacteriostasis And Osseointegration</p>

Abstract

BackgroundAlthough tantalum (Ta)-based coatings have been proven to have good antibacterial activity, the underlying mechanism and in vivo biological performance remain unclear, which are essential for the clinical application of Ta-coated biomaterials as dental implants.PurposeThe main objective of this study is to investigate the antibacterial activity of Ta-modified titanium (Ti) implants against peri-implantitis-related microbes and the potential molecular mechanisms.MethodsFusobacterium nucleatum and Porphyromonas gingivalis were selected to evaluate the antibacterial activity and potential antibacterial mechanism of Ta modification. The in vivo biocompatibility of Ta-modified implants was also evaluated.ResultsThe results showed that Ta-modified surface performed excellent antimicrobial activity against Fusobacterium nucleatum and Porphyromonas gingivalis. Micro galvanic might be formed between the incorporated Ta and the Ti base, which could consume the protons and result in decreased ATP synthesis and increased ROS generation. The gene expression of bacterial virulence factors associated with cellular attachment, invasion and viability as the target of ROS was downregulated. Importantly, in vivo biological studies showed that Ta modification significantly promoted the osseointegration of implants by stimulating the expression of bone-forming proteins.ConclusionThis study may provide some insights into clinical applications of Ta-coated Ti implants, especially in possibly infected situations.

Nerve growth factor-chondroitin sulfate/hydroxyapatite-coating composite implant induces early osseointegration and nerve regeneration of peri-implant tissues in Beagle dogs

“…In accordance with reports in the literatures, we discovered that the modification of multiple Ti dental implants contributes to the peri-implant tissues. For example, different shapes of nanostructured ceria-coated Ti surfaces could improve the antibacterial and anti-inflammatory properties of dental implants [ 62 ]; tantalum-modified Ti implants have also proven to have good superior bacteriostasis and osseointegration [ 63 ]; silanization-modified Ti implants could dramatically improve bone resorption induced by peri-implantitis in Beagle dogs [ 64 ]; minocycline hydrochloride-loaded graphene oxide (GO)-modified Ti implants also have certain therapeutic action on the peri-implantitis in Beagle dogs [ 65 ]. However, these modified Ti dental implants are only proven to be antibacterial, inhibit inflammation, or improve bone absorption in peri-implant tissues.…”

Surface Modified Techniques and Emerging Functional Coating of Dental Implants

“…Meanwhile, In addition, tantalum-based implants have shown excellent biocompatibility and safety in previous dentistry literature [151]. Related research showed that Tantalum (Ta)-treated Ti surface also demonstrated excellent antimicrobial activity against F. nucleatum and P. gingivalis, which could also activate the secretion of bone-forming proteins to promote the osseointegration between bone-to-implant surface [152].…”

Metallic Antibacterial Surface Treatments of Dental and Orthopedic Materials

“…Tantalum (Ta) is also a potential antibacterial agent which can hinder biofilm formation. Zhang et al modified Ti implant surfaces with Ta and observed excellent antibacterial activity against F. nucleatum and P. gingivalis ( Figure 5 ) [ 45 ].…”

“…ROS refer to single-electron reduction products of oxygen, including superoxide anion (O 2− ), hydroxyl radical (OH − ), and hydrogen peroxide (H 2 O 2 ) [ 91 ]. ROS generation is the most common and widely accepted mechanism for the antibacterial activity of several metallic agents, such as Ag, ZnO, TiO 2 and Ta [ 45 , 47 , 61 , 88 , 92 ]. As photocatalytic agents, ZnO and TiO 2 have common ROS generation that is different from other metallic agents.…”

“… The possible antibacterial mechanisms underlying the antimicrobial activity phenomenon of SLA-Ta surface. Reproduced with permission from ref [ 45 ]. …”