<p>Tear Film Characteristics During Wear of Daily Disposable Contact Lenses</p>

Abstract

To evaluate changes induced over time by three daily disposable (DD) contact lenses on tear meniscus height (TMH), pre-lens non-invasive break-up time (pre-lens NIBUT), tear film osmolarity (TO) and objective quality of vision (OQV). Patients and Methods: Forty-six subjects enrolled in this prospective open-label unmasked non-randomized simultaneous comparative cross-over study. For the first week of the study, subjects wore a nesofilcon A lens in the right eye and a delefilcon A lens in the left eye. After 3 days of washout, for the second week, subjects wore a nesofilcon A lens in the left eye and a stenfilcon A lens in the right eye. TMH, pre-lens NIBUT, TO and OQV were measured before contact lens fitting and for each contact lens combination on day 1 at 20 minutes and on day 7 after ≥8 hours of wear. OQV measurement included the changes of objective scatter index (OSI), the stability index (SI) and the fluctuation index (FI) calculated in a range of time of 20 s from a blink. Results: TMH was unchanged at 20 minutes wear of all lenses but was significantly reduced after 8 or more hours wear (on day 7) of delefilcon A and stenfilcon A, respectively. Pre-lens NIBUT was significantly reduced with all lenses, while no significant change in TO was observed with any lens. SI and FI increased significantly for all lenses at both wear times. Conclusion: While the presence of any contact lens on the eye challenges the tear film, nesofilcon A contact lenses, despite their high water content, compared to delefilcon A and stenfilcon A contact lenses, showed a lower overall effect. We speculate that superior tear film behavior while wearing nesofilcon A lenses may translate to improved subjective comfort, but this remains to be evaluated.

Comparison of the Pre-Lens Tear Film Stability and Visual Performance of a Novel and Two Other Daily Disposable Contact Lenses in Healthcare Professionals Wearing Facial Masks for Prolonged Time

“…Nesofilcon A is a new generation hydrogel DDCL that has a surface wetting technology with a polymer-bound macromer for maintaining a higher water content 78%. 12 A stable average NIBUT score with 8 h of wearing was previously reported in both presbyopic and non-presbyopic wearers. 19 However, the nesofilcon A group showed the lowest scores from the beginning of 4 h to 12 h compared to the other two SiHy DDCL groups.…”

“…11 Nesofilcon A (Biotrue ONEday™, Bausch & Lomb, Rochester, New York, USA) is a widely used, high-quality, and well-accepted conventional hydrogel (Hy) DDCL material with 78% water content throughout and a surface that retains water, like the natural tear film of the polymer-bound surface active macromer poloxamer 407. 12 To identify the most appropriate DDCL material in terms of tear film stabilization, ocular comfort levels, and visual quality for prolonged use, we compared the novel SiHy DDCL of Verofilcon A with another SiHy DDCL of Senofilcon A and a Hy DDCL of nesofilcon A.…”

Prevention of localized corneal hyperosmolarity spikes by soft-contact-lens wear

“…Although break-up areas cannot be visualized with fluorescein dye during SCL wear, non-invasive tear break-up analysis using concentric ring patterns confirms that the PrLTF exhibits tear break up [38,40]. Therefore, localized evaporation-driven osmolarity spikes in the PrLTF are anticipated to be similar to those on the pre-corneal tear film during no-lens wear.…”

Variability of Accommodative Microfluctuations in Myopic and Emmetropic Juveniles during Sustained near Work

“…Previous studies have confirmed that 3–5 min adaption is enough for accommodation [ 29 , 30 , 31 ]. Montani [ 32 ] also found that tear film was unchanged at 20 min wear of all lenses but was significantly reduced after 8 h. Hence, the 20 min rest is more than sufficient for accommodation and tear-film adaption. Sanders and McCormick pointed out that when reading a book or paper-like material, the normal reading distance is usually somewhere between 305 and 406 mm, with a mean of 355 mm.…”