&lt;p&gt;The Clinical Diagnostic and Prognostic Value of Dickkopf-1 in Cancer&lt;/p&gt;

Li, Jie; Gao, Yan; Yue, Wentao

doi:10.2147/cmar.s254596

Cited by 6 publications

(6 citation statements)

References 60 publications

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“…It is strongly expressed in both HDFs and mCAFs. The interpretation of this finding is complicated because its role as tumour-promoting and tumour-inhibiting factor was described (Li et al 2020 ). Since the knockdown of Dickkopf-1 has a suppressive role in apoptosis induced by the combination of temsirolimus and temozolomide in vitro, it should be hypothesised that its role in cutaneous melanoma is tumour suppressing (Niessner et al 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Exosomes produced by melanoma cells significantly influence the biological properties of normal and cancer-associated fibroblasts

Strnadová

Pfeiferová

Přikryl

et al. 2021

Histochem Cell Biol

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The incidence of cutaneous malignant melanoma is increasing worldwide. While the treatment of initial stages of the disease is simple, the advanced disease frequently remains fatal despite novel therapeutic options . This requires identification of novel therapeutic targets in melanoma. Similarly to other types of tumours, the cancer microenvironment plays a prominent role and determines the biological properties of melanoma. Importantly, melanoma cell-produced exosomes represent an important tool of intercellular communication within this cancer ecosystem. We have focused on potential differences in the activity of exosomes produced by melanoma cells towards melanoma-associated fibroblasts and normal dermal fibroblasts. Cancer-associated fibroblasts were activated by the melanoma cell-produced exosomes significantly more than their normal counterparts, as assessed by increased transcription of genes for inflammation-supporting cytokines and chemokines, namely IL-6 or IL-8. We have observed that the response is dependent on the duration of the stimulus via exosomes and also on the quantity of exosomes. Our study demonstrates that melanoma-produced exosomes significantly stimulate the tumour-promoting proinflammatory activity of cancer-associated fibroblasts. This may represent a potential new target of oncologic therapy .

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Section: Discussionmentioning

confidence: 99%

Exosomes produced by melanoma cells significantly influence the biological properties of normal and cancer-associated fibroblasts

Strnadová

Pfeiferová

Přikryl

et al. 2021

Histochem Cell Biol

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“…glycoproteins that modulate WNT signaling mainly by binding to LRP5/6, preventing the triggering of signaling (37). These features of DKK proteins are being explored due to its role in different types of cancers (38,39). Additionally, other antagonists such as WNT inhibitor factor 1 (WIF1), frizzled-related protein family (FRP)also referred as secreted frizzled-related proteins (sFRP)and Cerberus work in similar ways (40).…”

Section: Wnt Signaling Pathway and Its Role In Glioblastomamentioning

confidence: 99%

Multifaceted WNT Signaling at the Crossroads Between Epithelial-Mesenchymal Transition and Autophagy in Glioblastoma

et al. 2020

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“…The clinical diagnostic and prognostic value of serum levels of DKK1 in human cancers is well documented in the literature 22 , 23 . Up to now, however, little is known about circulating levels of DKK1 in PE.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Maternal Serum Levels and Placental mRNA Levels of Dickkopf-1 in Preeclamptic and Normal Pregnant Women at Delivery

Kasoha

Takács

Fackiner

et al. 2021

Geburtshilfe Frauenheilkd

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Background Preeclampsia remains a major cause of perinatal and maternal mortality and morbidity worldwide. Wnt/β-catenin signaling is known to be critically involved in placenta development processes. Dickkopf-1 (DKK1) is a key regulator of this transduction pathway. The aim of this study is to compare maternal serum DKK1 levels and placental mRNA levels of DKK1 and β-catenin in preeclamptic and normal pregnant women at delivery. Methods The present study included 30 women with preeclampsia and 30 women with normal pregnancy. Maternal serum DKK1 levels were measured by ELISA. Placental mRNA levels of DKK1 and β-catenin were detected using RT-PCR. Results Decreased maternal serum DKK1 levels were associated with worse maternal and fetal complications including HELLP syndrome, determination of one or more pathological symptom and IUGR diagnosis. No significant difference in maternal serum DKK1 levels was reported between preeclamptic women and women with normal pregnancy. Placental mRNA DKK1 levels were lower in preeclamptic women compared with normal pregnant women. Placental mRNA β-catenin levels showed no significant difference between two groups. Conclusions Our findings reported the aberrant placental mRNA DKK1 levels in patients with preeclampsia. In addition, worse preeclampsia features were associated with decreased maternal serum DKK1 levels. Hence, aberrant Wnt/β-catenin signaling might present a plausible mechanism in preeclampsia pathogenicity. Dysregulated expression of DKK1 at gene level in the placenta but not at protein level in the maternal serum might confirm the notion that preeclampsia is a type of placenta-derived disease.

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<p>The Clinical Diagnostic and Prognostic Value of Dickkopf-1 in Cancer</p>

Cited by 6 publications

References 60 publications

Exosomes produced by melanoma cells significantly influence the biological properties of normal and cancer-associated fibroblasts

Exosomes produced by melanoma cells significantly influence the biological properties of normal and cancer-associated fibroblasts

Multifaceted WNT Signaling at the Crossroads Between Epithelial-Mesenchymal Transition and Autophagy in Glioblastoma

Comparison of Maternal Serum Levels and Placental mRNA Levels of Dickkopf-1 in Preeclamptic and Normal Pregnant Women at Delivery

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