<p>The Effect of Admission Serum Magnesium on the Acute Kidney Injury Among Patients with Malignancy</p>

Abstract

This study aimed to explore the relationship between serum magnesium (Mg) levels and incidence of acute kidney injury (AKI) in patients with malignancy. Patients and Methods: Hospitalized patients with malignancy between October 1, 2014 and September 30, 2015 in Zhongshan Hospital were recruited. All relevant data were extracted from the electronic database. Results: All 99,845 patients were enrolled and 16,082 eligible patients were divided into three groups according to admission serum Mg levels in this study. Among them, 2383 (14.8%) cases were diagnosed as AKI. The incidence of AKI showed a V trend with the increase of serum Mg level. The effect of low serum Mg level on the onset of AKI seems to be greater than high serum Mg level. Patients with low serum Mg level spent a longer time in the hospital than those with normal serum Mg level and high serum Mg level. Further, multivariate logistic regression model was used to assess the importance of serum Mg level to influence AKI incidence. There was a higher AKI incidence in patients with magnesium level 0.66mmol/L or less (aOR=2.438, 95% CI=1.696, 3.505). Conclusion: Low serum Mg level might be a independent risk factor for AKI in patients with malignancy. Appropriate clinical intervention for serum Mg disorder may contribute to decreasing the incidence of AKI and the possibility of poor outcomes in cancer patients.

Admission electrolyte and osmotic pressure levels are associated with the incidence of contrast-associated acute kidney injury

“…It can counteract vasoconstriction by endogenous catecholamines and potentiate the action of endogenous vasodilators 25 . In a study by Shen et al 13 , they found that low serum magnesium was an independent risk factor for AKI in patients with malignancy, while Cheungpasitporn et al . 26 revealed that both admission hypomagnesemia and hypermagnesemia increased the risk for AKI.…”

Acute Kidney Injury after Multiple Cycles of Cisplatin Chemotherapy: A Nomogram for Risk Assessment

“…However, in this study, low albumin was not an independent risk factor for AKI, which was considered to be related to the insufficient sample size. Shen et al [ 38 ] showed that hypomagnesemia was associated with a higher incidence of AKI in patients with malignant tumors. When serum magnesium was normal (0.67–1.04 mmol/L), the incidence of AKI was the lowest.…”

Hypomagnesemia Is Associated with the Acute Kidney Injury in Traumatic Brain Injury Patients: A Pilot Study

“…Several previous studies have explored the correlation between serum magnesium and the AKI risk in other kinds of patients including critically ill children, acute pancreatitis, cancer, and those undergoing cardiac surgery [ 19 , 20 , 21 , 22 ]. Three of them discovered that hypomagnesemia was independently correlated with the higher risk of AKI while another one found hypermagnesemia but not hypomagnesemia was correlated with the AKI in critically ill children [ 19 , 20 , 21 , 22 ]. Furthermore, one study with a large sample size verified that both hypermagnesemia and hypomagnesemia could increase the AKI risk in general hospitalized patients [ 27 ].…”

“…The serum magnesium level would be influenced by several factors such as thyroid hormone, malnutrition, and gastrointestinal absorption. Additionally, previous studies have found that abnormal serum magnesium level was associated with the AKI development in several kinds of patients, including critically ill children, those diagnosed with acute pancreatitis, cancer, or undergoing cardiac surgery [ 19 , 20 , 21 , 22 ]. Despite this, there is still no study exploring the relationship between serum magnesium level and the AKI development in TBI patients.…”