&lt;p&gt;The effects and mechanisms of a biosynthetic ginsenoside 3β,12β-Di-O-Glc-PPD on non-small cell lung cancer&lt;/p&gt;

Huang, Lulu; Tang, Ming; Du, Qianqian; Liu, Chunxia; Yang, Jin-Ling; Li, Yan

doi:10.2147/ott.s217039

Cited by 10 publications

(5 citation statements)

References 39 publications

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“…Tea tree oil Leaves of Melaleuca alternifolia Antibacterial, anti-inflammatory, reduces sebum production [183] Aloe vera Leaves of Aloe vera plant Anti-inflammatory, wound healing, moisturizing [184] Green tea extract Leaves of Camellia sinensis plant Antioxidant, anti-inflammatory, reduces sebum production [185] Licorice extract Roots of Glycyrrhiza glabra plant Anti-inflammatory, antioxidant, antibacterial [186] Turmeric extract Roots of Curcuma longa plant Anti-inflammatory, antibacterial, antioxidant [187] Neem extract Leaves of Azadirachta indica tree Antibacterial, anti-inflammatory, reduces sebum production [188] Chamomile extract…”

Section: Active Herbal Ingredient Source Potential Benefits For Acne ...mentioning

confidence: 99%

Recent advances in nanofiber-based systems for acne treatment: A comprehensive review

Tören¹,

Buzgo²

2023

Preprint

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Encapsulated nanofibers have emerged as a promising approach for the treatment of acne, owing to their ability to provide controlled release, targeted delivery, increased efficacy, and improved stability. Electrospinning is a well-established method for producing encapsulated nanofibers and has been shown to be effective for encapsulating various active ingredients. However, there are still several challenges that need to be addressed in the development of encapsulated nanofibers for acne treatment. One major challenge is the need for comprehensive in vitro and in vivo studies to evaluate the safety and efficacy of these treatments. The cost and scalability of production also need to be considered to make these treatments accessible and affordable for patients. In addition, the long-term stability of encapsulated active ingredients is another challenge in the development of encapsulated nanofibers for acne treatment. Regulatory frameworks need to be developed to ensure the safety and efficacy of these treatments. Future research may focus on developing multifunctional nanofibers that combine active ingredients with other properties, such as antimicrobial, anti-inflammatory, and wound-healing properties, to provide a comprehensive approach to acne treatment. Moreover, the development of nanofiber-based skincare products may have a significant impact on the cosmetic industry. Overall, while there are still challenges to overcome, the potential benefits of encapsulated nanofibers for acne treatment make them an exciting and promising area of research for the future. In particular, the integration of smart drug delivery systems and responsive materials may enable the development of more personalized and effective treatments for acne. The development of new materials and encapsulation techniques, as well as the exploration of combination therapies that target multiple aspects of acne pathogenesis, are also future perspectives for encapsulated nanofibers in acne treatment.

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Section: Active Herbal Ingredient Source Potential Benefits For Acne ...mentioning

confidence: 99%

Recent advances in nanofiber-based systems for acne treatment: A comprehensive review

Tören¹,

Buzgo²

2023

Preprint

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“…Consequently, most ginsenoside studies on lung cancer have been focused on NSCLC. A recent study reported that C 3 C 12 PPD, a newly discovered ginsenoside, inhibited cell growth, proliferation, migration, and tube formation of NSCLC in vivo and in vitro by inhibiting several signaling pathways, such as Raf/MEK/ERK, AKT/mTOR, and AKT/GSK-3 β / β -catenin [ 113 ]. Furthermore, CK suppressed cell viability by downregulating HIF-1 α mediated glucose metabolism and increased autophagy-mediated apoptosis via AMPK-mTOR and JNK signaling pathways in NSCLC [ 114 ].…”

Section: Lung Cancermentioning

confidence: 99%

Anticancer Activities of Ginsenosides, the Main Active Components of Ginseng

Hong

Baatar

Hwang

2021

Evidence-Based Complementary and Alternative Medicine

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Cancer incidence rate has been increasing drastically in recent years. One of the many cancer treatment methods is chemotherapy. Traditional medicine, in the form of complementary and alternative therapy, is actively used to treat cancer, and many herbs and active ingredients of such therapies are being intensely studied to integrate them into modern medicine. Ginseng is traditionally used as a nourishing tonic and for treating various diseases in Asian countries. The therapeutic potential of ginseng in modern medicine has been studied extensively; the main bioactive component of ginseng is ginsenosides, which have gathered attention, particularly for their prospects in the treatment of fatal diseases such as cancer. Ginsenosides displayed their anticancer and antimetastatic properties not only via restricting cancer cell proliferation, viability, invasion, and migration but also by promoting apoptosis, cell cycle arrest, and autophagy in several cancers, such as breast, brain, liver, gastric, and lung cancer. Additionally, ginsenosides can work synergistically with already existing cancer therapies. Thus, ginsenosides may be used alone or in combination with other pharmaceutical agents in new therapeutic strategies for cancer. To date however, there is little systematic summary available for the anticancer effects and therapeutic potential of ginsenosides. Therefore, we have reviewed and discussed all available literature in order to facilitate further research of ginsenosides in this manuscript.

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“…Herbal medicines are gaining popularity for the treatment of chronic and complex diseases as it works by hitting multiple molecular targets to modulate signaling pathways. An example of this is the study carried out by Huang [33] in which a biosynthetic ginsenoside mediated lung cancer by inhibiting Raf/MEK/ERK signaling pathway. Also, this is evident in the case of Marsdenia tenacissima extract suppressed lung cancer through ERK activation [34].…”

Section: Introductionmentioning

confidence: 99%

Echinacoside Induces Mitochondria-Mediated Pyroptosis through Raf/MEK/ERK Signaling in Non-Small Cell Lung Cancer Cells

Shi

Cao

Liu

et al. 2022

Journal of Immunology Research

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Background. Various natural compounds are effective in cancer prevention and treatment with fewer side effects than conventional radiotherapy and chemotherapy. Considering the uncertainty of the antitumor mechanism of Echinacoside (Ech) and the fact that no study on Ech against non-small cell lung cancer (NSCLC) has been explored previously, this study inquired into the anti-NSCLC effect of Ech and explored its potential mechanisms. Methods. The IC50 to Ech of the NSCLC cells was calculated based on a series of cell viability assays. Different concentrations of Ech were used to treat the cells; the proliferation activity of the cells was evaluated using EdU staining. Mitochondrial membrane potential was detected by JC-1 staining. Levels of cytokines IL-1β and IL-18 were measured by ELISA. GSH and MDA levels were measured by microplate reader. Expression of cytochrome c, NLRP3, caspase-1, IL-1β, c-Myc, c-Fos, and Raf/MEK/ERK pathway proteins was evaluated by western blot. Meanwhile, we used xenograft, immunohistochemical staining, and H&E staining to evaluate the pharmacological effects of Ech in mice in vivo. Results. ECH inhibited the proliferation of NSCLC cells. Ech increased the expression of pyroptosis-related proteins. Besides, Ech perturbed the mitochondrial membrane potential with the release of mitochondrial cytochrome c, accompanied by increased oxidative stress. Ech inhibited the phosphorylation levels of Raf/MEK/ERK signaling pathway and subsequently reduced c-myc and c-fos protein expression. In addition, Ech effectively restrained the growth of tumors in vivo. Conclusions. Ech inhibited the Raf/MEK/ERK signaling. Impaired mitochondria activated inflammasome, which in turn led to the pyroptosis of NSCLC cells. These findings can provide some ideas on how to use pyroptosis to treat NSCLC.

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<p>The effects and mechanisms of a biosynthetic ginsenoside 3β,12β-Di-O-Glc-PPD on non-small cell lung cancer</p>

Cited by 10 publications

References 39 publications

Recent advances in nanofiber-based systems for acne treatment: A comprehensive review

Recent advances in nanofiber-based systems for acne treatment: A comprehensive review

Anticancer Activities of Ginsenosides, the Main Active Components of Ginseng

Echinacoside Induces Mitochondria-Mediated Pyroptosis through Raf/MEK/ERK Signaling in Non-Small Cell Lung Cancer Cells

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