<p>The impact of changes in serum levels of metalloproteinase-2 and metalloproteinase-9 on pain perception in patients with disc herniation before and after surgery</p>

Abstract

Purpose: The aim of our research was to investigate the link between serum levels of metalloproteinase-2 (MMP-2) and MMP-9, and the degree of pain experienced before and 1 and 3 months after microdiscectomy in 70 patients with disc herniation (DH). Patients and methods: The control group (group C) consisted of 70 healthy subjects and the DH group consisted of 70 patients with sciatica pain caused by lumbar DH. Before (DH0) and 1 and 3 months after surgery, the patients were assessed in terms of the following biochemical parameters: MMP-2, tissue inhibitors of metalloproteinases-2 (TIMP-2), MMP-2/TIMP-2, MMP-9, TIMP-1, and MMP-9/TIMP1, and the following clinical parameters: Numeric Rating Scale for the back (NRS-B) and the leg (NRS-L) and the Pain Rating Index (PRI) and Present Pain Intensity (PPI) of the McGill Pain Questionnaire. Results: No statistically significant correlations were observed following the biochemical and clinical assessments performed in group C and the DH group before surgery. After surgery (1 month), higher levels of TIMP-1 correlated with higher levels of NRS-B (rs =0.27; p <0.05). At 3 months after surgery higher levels of TIMP-2 and lower levels of MMP-2/TIMP-2 were correlated with higher levels of NRS-L (rs =0.27, p <0.05 and rs =−0.31, p <0.05, respectively) and higher levels of TIMP-2 were correlated with higher PRI scores (rs =0.27; p <0.005) and PPI scores (rs =0.35; p <0.01). Conclusion: The results showed that MMPs are involved in DH and play a significant role in the perception of pain after DH surgery. However, the value of MMPs as a potential therapeutic target in pain treatment should be considered cautiously.

Metalloproteinase-2 in failed back surgery syndrome caused by epidural fibrosis: can it play a role in persistent pain?

“…In animal models, after spinal nerve ligation, MMP-2 shows a delayed upregulation in injured DRG (dorsal roots ganglion) satellite cells and spinal astrocytes in a late phase of NP (Haro, 2014). Although the observations based on animals are not fully consistent with the results of research on humans (Kamieniak et al, 2019), one can assume the contribution of MMP-2 in NP. We noticed some correlations between MMP-2, TIMP-2, and MMP-2/TIMP-2 and PI in the DH group.…”

Bioinformatics and systems biology approach to identify the pathogenetic link of neurological pain and major depressive disorder

“…Decreased MMP9 levels result in decreased neuronal differentiation in the hippocampus and may cause increased anxiety in mice [ 72 ]. Four TIMPs(TIMP1, TIMP2, TIMP3, TIMP4) are physiological tissue inhibitors of MMPs, of which TIMP2 can indirectly affect NP and MDD processes by inhibiting MMP9 activity [ 73 , 74 ]. These studies confirm the results of our database analysis that MMP9 and TIMP2 have some diagnostic value for NP and MDD.…”

Umurtqalararo Disk Churralarida Toʻqimali Metalloproteinaza (Mmp-1, MMP-8, MMP-9) Va Uning Ingibitorlari (Mpti-1) Darajasiga Papaya Preparatlarining Taʼsiri

“…Odatda, bu fermentlar juda oz miqdorda ekspressiyalanadi hamda ularning transkripsiyasi gormonlar, sitokinlar va oʻsish omillari (IL-1, IL-4, IL-6), transformatsiyalovchi oʻsish omillari (EGF, HGF, TGFβ) yoki alfa oʻsimta nekrozi omili (TNF-α, tumor necrosis factor α) tomonidan ham ijobiy, ham salbiy tomonga tartibga solinadi. Ushbu molekulalarning ayrimlari oʻz navbatida MMPs tomonidan proteolitik yoʻl orqali inaktivlashtirilishi mumkin (teskari aloqa samarasi) [12]. Har qanday shikastlanish yoki infeksiya erkin radikallar shakllanishining faollashuvi va/yoki ularning yetarli darajada inaktivatsiyasi orqali MMPs tizimini faollashtirishi mumkin.…”

“…Har qanday shikastlanish yoki infeksiya erkin radikallar shakllanishining faollashuvi va/yoki ularning yetarli darajada inaktivatsiyasi orqali MMPs tizimini faollashtirishi mumkin. Erkin radikallar tomonidan MMPs ning faollashuvi fermentning allosterik markaziga superoksidning bevosita taʼsiri va MMPs genlarining transkripsiyasini oshiruvchi NF-κB transkripsiya omilining faollashishi bilan amalga oshiriladi [12].…”