Purpose: To assess the difference in visual acuity and optical quality between two monofocal intraocular lens (IOL) models Material and Methods: Prospective, parallel and randomized clinical study. Sixty patients were implanted bilaterally, 30 per group, with IOL TECNIS® ZCB00 or Clareon® CNA0T0. Visual outcomes obtained at 1 and 3 months after surgery included both uncorrected and corrected monocular distance visual acuity (UCVA and DCVA, respectively), objective index scattering (OSI), modulation transfer function cutoff(MTF), Strehl Ratio (SR), contrast sensitivity (CS) defocus curve, IOL's spherical aberration (SA), and eye's longitudinal chromatic aberration (LCA). Patient's satisfaction was assessed using CatQuest-9SF questionnaire at 3 months postoperatively. Results: Regarding all the parameters assessed, there were statistically significant differences for DCVA (p = .008), OSI (p= .050) and SR (p= .003) between groups. Outcomes related to CS defocus curve showed statistically significant differences for vergences between -0.50 D and +1.00 D (3 mm pupil) and for vergences of 0.00 D and +0,50 D (4.5 mm pupil) between groups. Overall, IOL TECNIS® showed better results regarding visual acuity and optical quality, including a lower LCA result in comparison to Clareon®. Patient's satisfaction evaluated with CatQuest-9SF showed that TECNIS group achieved better outcomes although the differences were statistically significant only for the 'Reading text on television' item (p = 0.027). Conclusion: Both IOL models showed excellent quantity of vision, optical and visual quality as well as high patient's satisfaction after cataract surgery. Despite it, the TECNIS® ZCB00 model did provide slightly better outcomes, yet statistically significant, than the Clareon® CNA0T0