<p>The Impact of Lung Function on Extra-Pulmonary Diseases and All-Cause Mortality in US Adult Population with and without COPD</p>

Abstract

Spirometric lung function is usually used to evaluate respiratory health. However, the impact of lung function on extra-pulmonary diseases and all-cause mortality has not been fully elucidated, especially in people without chronic obstructive pulmonary disease (COPD). Patients and Methods: Participants aged ≥20 and underwent spirometry test from the US National Health and Nutrition Examination Surveys (NHANES) 2007-2012 were analyzed in this study. Multivariate logistic and Cox regressions were used to evaluate the impact of forced expiratory volume in 1 second percent of predicted (FEV 1 % predicted) and forced vital capacity percent of predicted (FVC% predicted) on 14 extra-pulmonary diseases and all-cause morbidity after adjusting for multiple confounders. Results: During 2007-2012, 1800 COPD patients and 11,437 non-COPD subjects were included. The prevalence of hypertension, diabetes mellitus (DM), dyslipidemia, metabolic syndrome (MS), congestive heart failure (CHF), coronary disease, stroke, chronic kidney disease (CKD), arthritis, cancer, underweight and osteoporosis in COPD patients was higher than that in the non-COPD population. After adjusting for confounders, the decrease of FEV 1 % predicted and FVC% predicted was related with higher odds of having hypertension, DM, obesity, MS, CHF, coronary disease and depression (OR > 1, P<0.05) in both the COPD and non-COPD populations. These 2 indices were also related with higher odds of dyslipidemia, CKD, arthritis and osteoporosis in the non-COPD population. The risk of stroke, anemia and cancer was not related with the decrease of lung function. In addition, the decrease of lung function was independent risk factors for the increase of all-cause mortality. These risks were gradually increased with the decrease of lung function. Conclusion: The decrease of FEV 1 % predicted and FVC% predicted was related with higher risk of multiple extra-pulmonary diseases and all-cause mortality in both the COPD and non-COPD population.

The association between periodontitis and lung function: Results from the National Health and Nutrition Examination Survey 2009 to 2012

“…Lung function outcomes included FEV1, FVC, and FEV1/FVC ratio 30 . Few participants underwent postbronchodilator spirometry in NHANES 2009 to 2012, based on other studies by NHANES, 31,32 we used prebronchodilator values in this study. We analyzed the relationship between periodontitis and lung function regarding airflow obstruction: participants with airflow obstruction (FEV1/FVC <0.70); and participants without airflow obstruction (FEV1/FVC ≥0.70) 33 …”

The impact of anemia on the mortality of COPD patients hospitalized for acute exacerbation resulting in respiratory failure

“…COPD is an inflammatory disease that is accompanied by numerous comorbidities. COPD has a higher prevalence of many concomitant diseases [14]. However, the relationship between anemia and the severity of COPD has only been studied in a few studies, and the results are conflicting.…”

“…Yang claims that the risk of anemia and cancer is unrelated to a decline in lung function. They go on to say that a decline in lung function is an independent risk factor for an increase in all-cause mortality [14]. Another study found that the overall prevalence of anemia is 27%, with no correlation between the severity of COPD and anemia [15].…”

Health-Related Quality of Life and Nutritional Status Are Related to Dietary Magnesium Intake in Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study

“…Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder characterized by lung function impairment [ 1 2 3 ] and is a fourth-leading cause of mortality, which expected to cause over 6 million death worldwide per year by 2030 [ 4 5 ]. COPD patients may suffer from muscle weakness, osteoporosis, diabetes, cardiovascular disease, hypertension, depression, and lung cancer [ 6 ].…”