&lt;p&gt;The impact of prostate-transurethral resection on erectile dysfunction in benign prostatic hyperplasia&lt;/p&gt;

Oka, Anak Agung Gde; Duarsa, Gede Wirya Kusuma; Novianti, Putu Astri; Mahadewa, Tjokorda Gde Bagus; Ryalino, Christopher

doi:10.2147/rru.s189414

Cited by 8 publications

(13 citation statements)

References 18 publications

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“…3 The level of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta (TGF-β), and interleukins. 4 Inflammation-induced growth factors have long been linked linearly to the development of BPH. 5 Testosterone was recognized to increase the prostate volume especially in testosterone replacement therapy.…”

Section: Introductionmentioning

confidence: 99%

<p>Risk Factors for Prostate Volume Progression After Prostate-Transurethral Resection</p>

Duarsa

Dau

Pramana

et al. 2020

RRU

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Background: Many factors could contribute to the cases of residual benign prostate hypertrophy (BPH) volume after transurethral resection of the prostate (TURP), such as age, obesity, testosterone level, and inflammation. The goal of this study was to determine the risk of tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β) in prostate tissue, serum prostate-specific antigen (PSA), serum testosterone, and age in promoting prostate volume progression after TURP. Patients and Methods: This was a prospective cohort study on 83 BPH patients who underwent TURP at five hospitals in Bali, Indonesia. Trans-rectal ultrasonography (TRUS) was carried out to examine the prostate's size. Three years after, we redo the TRUS examination to collect the data of the latest prostate size. TNF-α, TGF-β, serum PSA, testosterone, and age were registered for analysis. We used Pearson's and Spearman's correlation tests and multivariate analytic linear regression test (coefficient β) by SPSS 13.0 software. Results: Age, testosterone, PSA, TNF-α, TGF-β were positively correlated to prostate's volume progression. The prostate volume was strongly correlated with age (r= 0.749, p <0.001), PSA level (r=0.896, p <0.001), testosterone level (r=0.818, p <0.001), and TGF-β (r=0.609, p <0.001). The TNF-α level has a weak correlation to prostate's volume progression (r=0.392, p <0.001). Conclusion: TNF-α, TGF-β, PSA, testosterone, and age were significant as the risk factors in promoting the prostate volume progression after TURP.

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Section: Introductionmentioning

confidence: 99%

<p>Risk Factors for Prostate Volume Progression After Prostate-Transurethral Resection</p>

Duarsa

Dau

Pramana

et al. 2020

RRU

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Section: Discussionmentioning

confidence: 99%

“…Erectile dysfunction is strongly correlated with age [ 31 – 35 ]. The condition is correlated not only with the physiology of aging, but also with comorbidities and their treatment [ 31 – 33 ]. More than 70% of men over the age of 50 years have various diseases of the prostate, including BPH [ 6 , 12 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

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Transurethral Microwave Thermotherapy (TUMT) in the Treatment of Benign Prostatic Hyperplasia: A Preliminary Report

Ziętek¹,

Ziętek²

2021

Med Sci Monit

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Background One treatment option for benign prostatic hyperplasia (BPH) is transurethral microwave thermotherapy (TUMT). Unfortunately, TUMT has been increasingly marginalized recently. The aim of this study was to evaluate erectile function and urinary symptoms in patients after TUMT for BPH and compare the results with those of patients on pharmacological treatment for BPH. Material/Methods The study group consisted of 840 patients with BPH treated with TUMT and a control group consisting of 1040 patients who underwent pharmacotherapy. Erectile dysfunction was evaluated using the International Index of Erectile Function-5 questionnaire and the Individual Postoperative Erectile Assessment (IPEA) questionnaire, which was created by the authors for this study. Urinary symptoms were evaluated using the International Prostate Symptom Score (IPSS) questionnaire. Results More than 50% of all patients experienced an improvement in urinary symptoms after TUMT, compared with only approximately 30% in the control group. Differences in each of the IPSS symptom scales between the TUMT and control groups were statistically significant ( P <0.031, P <0.041, and P <0.025 for mild, moderate, and severe symptoms, respectively). Improvement in erectile dysfunction after TUMT was also statistically significant ( P <0.0001, P <0.0001, P <0.05 for mild, moderate, and severe erectile dysfunction, respectively). Based on the IPEA questionnaire, approximately 24% of the TUMT group reported significant improvement in erectile function, while a decrease in erectile function was reported in the control group. Conclusions TUMT may still be a valuable option in the treatment of BPH. TUMT may be especially suitable for patients who expect to improve urinary symptoms without decreasing erectile function.

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“… 6 Furthermore, medical (5 alpha reductase inhibitor and alpha blockers) and surgical therapies [simple prostatectomy, transurethral resection of the prostate (TURP), and laser enucleation] may cause retrograde ejaculation and/or worsen erectile function. 7 …”

Section: Introductionmentioning

confidence: 99%

Preserving ejaculatory function in young patients with lower urinary tract symptoms: medium- to long-term follow-up of prostatic urethral lift at a single center

Annese

D’Altilia

Mancini

et al. 2021

Therapeutic Advances in Urology

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Background and aims: Prostatic urethral lift (Urolift™) is a minimally invasive technique to treat male lower urinary tract symptoms (LUTSs) due to benign prostatic hyperplasia (BPH). The aim of the present study was to assess safety and medium- to long-term outcomes in the relief of urinary symptoms. Methods: We included 35 men, affected by severe symptomatic BPH evaluated by International Prostate Symptom Score (IPSS), with normal erectile function (EF) and ejaculatory function (EjF) evaluated by the International Index of Erectile Dysfunction (IIEF-5) and Male Sexual Health Questionnaire for Ejaculatory Dysfunction (MSHQ-EjD-SF). Exclusion criteria were prostate larger than 70 cm3, bladder neck sclerosis, concomitant third prostatic lobe, and/or other cervical urethral obstruction or cancer. All patients, preoperatively, performed uroflowmetry (UFM) with peak flow (Q-max) and post void residual volume (PVR), digital rectal exam, transrectal prostate ultrasound to measure prostate volume, PSA, and cystoscopy. Follow-up was scheduled at 1–3–6 months, then yearly, evaluating UFM, IPSS, IIEF-5, and MSHQ-EjD-SF. Results: All procedures were performed by a single senior surgeon and follow-up was 33.8 ± 12 months. Preoperative PSA was 0.82 ± 0.4 ng/ml and mean operative time was 19.6 ± 10 min and 3 (2–4) implants per patient were used. Parameters reported at last follow-up schedule were: Q-max increase of 68% ( p = 0.001), PVR reduction 68% ( p = 0.005), and IPSS reduction 55% ( p < 0.0001). EF and EjF were similarly preserved, and no patients presented retrograde ejaculation. A total of 88.6% of patients were satisfied with LUTSs improvement and 100% satisfied with EjF. Conclusion: Urolift can improve urinary disorders secondary to BPH, preserving EjF and EF. It is a safe and easy method, reproducible, and with low incidence of complications. Careful selection of patients is mandatory. The main reason for dissatisfaction is the higher expectation of better BPH symptoms relief although patients with high bladder neck and/or prostate volume >45 cm3 were aware of the possible failure.

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<p>The impact of prostate-transurethral resection on erectile dysfunction in benign prostatic hyperplasia</p>

Cited by 8 publications

References 18 publications

<p>Risk Factors for Prostate Volume Progression After Prostate-Transurethral Resection</p>

<p>Risk Factors for Prostate Volume Progression After Prostate-Transurethral Resection</p>

Transurethral Microwave Thermotherapy (TUMT) in the Treatment of Benign Prostatic Hyperplasia: A Preliminary Report

Preserving ejaculatory function in young patients with lower urinary tract symptoms: medium- to long-term follow-up of prostatic urethral lift at a single center

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