&lt;p&gt;The Inflammatory Aspect of Male and Female Pattern Hair Loss&lt;/p&gt;

Peyravian, Nadia; Deo, Sapna K.; Daunert, Sylvia; Jiménez, Joaquín J.

doi:10.2147/jir.s275785

Cited by 33 publications

(25 citation statements)

References 20 publications

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“…We also found that alopecia increased over time that it mainly affected women, and at 90 days, the proportion of women who suffered alopecia was double that of men. Possible reasons for alopecia in women include inflammation and immunity 22 , 23 and a possible association with emotional distress, 24 which seems plausible given the high proportion of patients in our population who reported sadness and anxiety. These findings indicate that healthcare systems must develop strategies to provide mental health support to COVID-19 survivors with persistent symptoms.…”

Section: Discussionmentioning

confidence: 92%

Symptom cluster analysis of long COVID-19 in patients discharged from the Temporary COVID-19 Hospital in Mexico City

Wong‐Chew

Cabrera²,

Valdez³

et al. 2022

Therapeutic Advances in Infection

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Introduction: Several reports have emerged describing the long-term consequences of COVID-19 and its effects on multiple systems. Methods: As further research is needed, we conducted a longitudinal observational study to report the prevalence and associated risk factors of the long-term health consequences of COVID-19 by symptom clusters in patients discharged from the Temporary COVID-19 Hospital (TCH) in Mexico City. Self-reported clinical symptom data were collected via telephone calls over 90 days post-discharge. Among 4670 patients, we identified 45 symptoms across eight symptom clusters (neurological; mood disorders; systemic; respiratory; musculoskeletal; ear, nose, and throat; dermatological; and gastrointestinal). Results: We observed that the neurological, dermatological, and mood disorder symptom clusters persisted in >30% of patients at 90 days post-discharge. Although most symptoms decreased in frequency between day 30 and 90, alopecia and the dermatological symptom cluster significantly increased ( p < 0.00001). Women were more prone than men to develop long-term symptoms, and invasive mechanical ventilation also increased the frequency of symptoms at 30 days post-discharge. Conclusion: Overall, we observed that symptoms often persisted regardless of disease severity. We hope these findings will help promote public health strategies that ensure equity in the access to solutions focused on the long-term consequences of COVID-19.

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Section: Discussionmentioning

confidence: 92%

Symptom cluster analysis of long COVID-19 in patients discharged from the Temporary COVID-19 Hospital in Mexico City

Wong‐Chew

Cabrera²,

Valdez³

et al. 2022

Therapeutic Advances in Infection

View full text Add to dashboard Cite

show abstract

“…15 We also found that alopecia increased over time, that it mainly affected women, and at 90 days, the proportion of women who suffered alopecia was double that of men. Possible reasons for alopecia in women include inflammation and immunity 20,21 and a possible association with emotional distress, 22 which seems plausible given the high proportion of patients in our population who reported sadness and anxiety.…”

Section: Discussionmentioning

confidence: 92%

Symptom Cluster Analysis of long COVID-19 in Patients Discharged from the Temporary COVID-19 Hospital in Mexico City: A Longitudinal Study

Rm¹,

Exr²,

Car³

et al. 2021

Preprint

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Recently, several reports have emerged describing the long-term consequences of COVID-19 that may affect multiple systems, suggesting its chronicity. As further research is needed, we conducted a longitudinal observational study to report the prevalence and associated risk factors of long-term health consequences of COVID-19 by symptom clusters in patients discharged from the Temporary COVID-19 Hospital (TCH) in Mexico City. Self-reported clinical symptom data were collected via telephone calls over 90 days post-discharge. Among 4670 patients discharged from the TCH, we identified 45 symptoms across eight symptom clusters (neurological; mood disorders; systemic; respiratory; musculoskeletal; ear, nose, and throat; dermatological; and gastrointestinal). We observed that the neurological, dermatological, and mood disorder symptom clusters persisted in >30% of patients at 90 days post-discharge. Although most symptoms decreased in frequency between day 30 and 90, alopecia and the dermatological symptom cluster significantly increased (p<0·00001). Women were more prone than men to develop long-term symptoms and invasive mechanical ventilation also increased the frequency of symptoms at 30-days post-discharge. Overall, we observed that symptoms often persisted regardless of disease severity. We hope these findings will help promote public health strategies that ensure equity in the access to solutions focused on the long-term consequences of COVID-19.

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“…AGA is positively associated with immune modulation and inflammation, and thus, anti-inflammatory agents can be used to treat the condition [42]. In previous studies, PC was found to reduce the mRNA expressions of TNF-α and IL-6 and to combat chronic nonbacterial prostatitis (a male disease) and arteriosclerosis [39,43].…”

Section: Discussionmentioning

confidence: 99%

Alleviation of Androgenetic Alopecia with Aqueous Paeonia lactiflora and Poria cocos Extract Intake through Suppressing the Steroid Hormone and Inflammatory Pathway

Zhang

Cao

et al. 2021

Pharmaceuticals

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Paeonia lactiflora Pallas (PL) and Poria cocos Wolf (PC) have been traditionally used to treat inflammatory diseases reported in Dongui Bogam and Shen Nong Ben Cao Jing, traditional medical books in Korean and China, respectively. We determined the efficacies and the molecular mechanisms of PL, PC, and PL + PC aqueous extracts on androgenetic alopecia (AGA) induced by testosterone propionate in C57BL/6 mice. The molecular mechanisms of PL and PC in AGA treatment were examined using experimental assays and network pharmacology. The AGA model was generated by topically applying 0.5% testosterone propionate in 70% ethanol solution to the backs of mice daily for 28 days while the normal-control (Normal-Con; no AGA induction) mice applied 70% ethanol. The 0.1% PL (AGA-PL), 0.1% PC (AGA-PC), 0.05% PL + 0.05% PC (AGA-MIX), and 0.1% cellulose (AGA-Con; control) were supplemented in a high-fat diet for 28 days in AGA-induced mice. Positive-control (AGA-Positive) were administered 2% finasteride daily on the backs of the AGA mice. Hair growth rates decreased in the order of AGA-PL, AGA-MIX, AGA-PC, AGA-Positive, and AGA-Con after 21 days of treatment (ED21). On ED28, skins were completely covered with hair in the AGA-PL and AGA-MIX groups. Serum testosterone concentrations were lower in the AGA-PL group than in the AGA-Con group and similar to concentrations in the Normal-Con group, whereas serum 17β-estradiol concentrations showed the opposite pattern with increasing aromatase mRNA expression (p < 0.05). In the dorsal skin, DKK1 and NR3C2 mRNA expressions were significantly lower, but TGF-β2, β-Catenin, and PPARG expressions were higher in the AGA-PL and AGA-PC groups than in the AGA-Con group (p < 0.05), whereas TNF-α and IL-6 mRNA expressions were lower in the AGA-PL, AGA-MIX, and Normal-Con groups than in the AGA-Con group (p < 0.05). The phosphorylation of Akt and GSK-3β in the dorsal skin was lower in AGA-Con than normal-Con, and PL and MIX ingestion suppressed their decrease similar to the Normal-Con. In conclusion, PL or PL + PC intake had beneficial effects on hair growth similar to Normal-Con. The promotion was related to lower serum testosterone concentrations and pro-inflammatory cytokine levels, and inhibition of the steroid hormone pathway, consistent with network pharmacology analysis findings.

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<p>The Inflammatory Aspect of Male and Female Pattern Hair Loss</p>

Cited by 33 publications

References 20 publications

Symptom cluster analysis of long COVID-19 in patients discharged from the Temporary COVID-19 Hospital in Mexico City

Symptom cluster analysis of long COVID-19 in patients discharged from the Temporary COVID-19 Hospital in Mexico City

Symptom Cluster Analysis of long COVID-19 in Patients Discharged from the Temporary COVID-19 Hospital in Mexico City: A Longitudinal Study

Alleviation of Androgenetic Alopecia with Aqueous Paeonia lactiflora and Poria cocos Extract Intake through Suppressing the Steroid Hormone and Inflammatory Pathway

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