&lt;p&gt;The Prognostic Value of Inflammation Factors in Hepatocellular Carcinoma Patients with Hepatic Artery Interventional Treatments: A Retrospective Study&lt;/p&gt;

Guo, Linghong; Ren, Honghong; Pu, Lutong; Zhu, Xingyu; Liu, Yin; Ma, Xuelei

doi:10.2147/cmar.s257934

Cited by 19 publications

(12 citation statements)

References 60 publications

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“…AFR is a novel indicator reflecting inflammation and nutrition status [ 27 ], while NLR is reliably reflecting inflammation [ 28 ]. AFR and NLR were both widely used as prognostic indicators in various diseases [ 29 , 30 ]. These studies strongly suggest a close association between inflammation and POD.…”

Section: Discussionmentioning

confidence: 99%

Risk factors and a nomogram model for postoperative delirium in elderly gastric cancer patients after laparoscopic gastrectomy

Chen

Xing

2022

World J Surg Onc

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Background To evaluate the risk factors of postoperative delirium (POD) in elderly gastric cancer (GC) patients after laparoscopic gastrectomy and construct a predictive model. Methods Elderly GC patients undergoing laparoscopic gastrectomy were enrolled and grouped based on the status of POD development within postoperative 7 days. Independent risk factors were selected out by univariate and multivariate logistic regression analyses and then enrolled in the nomogram prediction model. Results A total of 270 elderly GC patients were enrolled, and POD occurred in 74 (27.4%) patients within postoperative 7 days. The results of multivariate regression analysis indicated that age (OR: 3.30, 95% CI: 1.41–6.85, P < 0.001), sleeping pills (OR: 1.87, 95% CI: 1.12–3.09, P = 0.012), duration of ICU stay (OR: 1.55, 95% CI: 1.02–2.37, P = 0.029), albumin/fibrinogen ratio (AFR) (OR: 1.74, 95% CI: 1.03–2.76, P = 0.019), and neutrophils/lymphocytes ratio (NLR) (OR: 2.12, 95% CI: 1.11–4.01, P = 0.016) were five independent risk factors for POD in elderly GC patients. The AUC of the constructed nomogram model based on these five factors was 0.807. Conclusions This study highlighted that age, AFR, NLR, sleeping pills taking, and duration of ICU stay were independent risk factors for POD, and the nomogram model based on these factors could effectively predict POD in elderly GC patients.

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Section: Discussionmentioning

confidence: 99%

Risk factors and a nomogram model for postoperative delirium in elderly gastric cancer patients after laparoscopic gastrectomy

Chen

Xing

2022

World J Surg Onc

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“…In recent years, the prediction model of prognosis of the HCC combined with different in ammation factors has always been a hot issue [9,10,29,30]. Previous studies have examined GLR's prognostic ability in HCC [14,31], intrahepatic cholangiocarcinoma [32] and nonfunctional pancreatic neuroendocrine tumors [25].…”

Section: Discussionmentioning

confidence: 99%

Non-Linear Relationship of Gamma-Glutamyl Transpeptidase To Lymphocyte Count Ratio With The Recurrence of Hepatocellular Carcinoma with Staging I-II: A Retrospective Cohort Study

Liang

Wen

et al. 2021

Preprint

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Background high recurrence rate was a major factor for poor postoperative prognosis of hepatocellular carcinoma (HCC) patients. The present study was intended to evaluate the association of gamma-glutamyl transpeptidase to lymphocyte count ratio (GLR) and the recurrence of HCC with staging I-II in Chinese. Methods the retrospective cohort data was derived from the First Affiliated Hospital of Zhengzhou University from January 2014 to December 2018 on 496 patients who underwent radical resection of HCC with staging I-II. Multivariable Cox regression models were used to determine hazard ratios (HR) and 95% confidence intervals (CIs) for the recurrence of HCC with staging I-II of each GLR tertile category. The restricted cubic spline model was used to find out the threshold effect. Results with the low tertile of GLR as the reference, multivariable-adjusted HRs and 95% CIs of the middle and high tertile categories were 1.748 (1.170, 2.612) and 2.078 (1.339, 3.227). In addition, there was a positive correlation (1.002 (1.001, 1.004)) and a non-liner relationship was found, whose point was 27.5. When the GLR was less than 27.5, the risk of recurrence increased, obviously with the increase in GLR levels (1.041 (1.014, 1.068)). Conclusions the GLR was independently associated with the recurrence of HCC patients with staging I-II. Furthermore, the relationship was positive and no-linear.

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“…Several clinical observational studies have demonstrated that elevated neutrophil count and increased NLR are used as markers of advanced disease, poor prognosis and poor response to therapy in patients with HCC [11][12][13][14] . Nevertheless, when it comes to causal inference, observational studies may be biased by confounding factors and reverse causality.…”

Section: Introductionmentioning

confidence: 99%

The Causal Relationship Between White Blood Cells Counts and Hepatocellular Carcinoma: A Mendelian Randomization Study

Pan

Yang

Shang

et al. 2022

Preprint

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Background Studies have reported that 90% of hepatocellular carcinoma (HCC) arise and progress on the background of chronic inflammation. The presence of infiltrating inflammatory cells is associated with tumor initiation, progression and clinical response to treatment. Whether white blood cells (WBC) subtypes counts increase or decrease the occurrence of HCC remains unclear. Methods In this study, we made a Mendelian randomization (MR) study with the validation of two datasets. The summary data for WBC counts were extracted from a recent large GWAS of the European ancestry individuals. We obtained GWAS data which related to HCC from UK Biobank (UKB). We performed univariable and multivariable MR analysis to identify whether genetic evidence of risk factors was significantly associated with HCC risks. Results In discovery dataset, multivariable MR analysis revealed that among the 8 traits of WBC counts, sum basophil neutrophil counts had an independent causal effect on occurrence of HCC. Sum basophil neutrophil counts: (OR = 0.437, P = 0.003, CI: 0.252–0.757). Similarly, in validation dataset, it was also observed that sum basophil neutrophil counts was the independent risk factor for HCC. Sum basophil neutrophil counts: (OR = 0.574, P = 0.021, CI: 0.358–0.920). Conclusion In European population, genetically-predicted the lower sum basophil neutrophil counts might be an independent risk factor of HCC.

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<p>The Prognostic Value of Inflammation Factors in Hepatocellular Carcinoma Patients with Hepatic Artery Interventional Treatments: A Retrospective Study</p>

Cited by 19 publications

References 60 publications

Risk factors and a nomogram model for postoperative delirium in elderly gastric cancer patients after laparoscopic gastrectomy

Risk factors and a nomogram model for postoperative delirium in elderly gastric cancer patients after laparoscopic gastrectomy

Non-Linear Relationship of Gamma-Glutamyl Transpeptidase To Lymphocyte Count Ratio With The Recurrence of Hepatocellular Carcinoma with Staging I-II: A Retrospective Cohort Study

The Causal Relationship Between White Blood Cells Counts and Hepatocellular Carcinoma: A Mendelian Randomization Study

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