&lt;p&gt;The Role of Albumin/Globulin Ratio in Discharged COVID-19 Patients with Re-Positive Nucleic Acid Detection&lt;/p&gt;

Yu, Hao; Li, Ting; Zheng, Chanfan; Jin, Shudong

doi:10.2147/jir.s270305

Cited by 4 publications

(4 citation statements)

References 6 publications

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“…Although the study did not directly point out the difference in SPD between the two groups, there was a direct correlation between length of stay and SPD (Chinese discharge criteria are described in “ Study design and participants ” section, the most important of which was the test of SARS-CoV-2 RNA negative) [ 14 ]. In another study of 23 re-positive patients, the median (IQR) SPD was essentially consistent with the results of our study (19 day [ 14 , 26 ], 20 [ 13 – 29 ], respectively) [ 18 ]. Unfortunately, they did not compare the difference between recurrent positive and non-recurrent positive group.…”

Section: Discussionsupporting

confidence: 91%

The relationship between SARS-COV-2 RNA positive duration and the risk of recurrent positive

et al. 2021

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Background The management of discharge COVID-19 patients with recurrent positive SARS-CoV-2 RNA is challenging. However, there are fewer scientific dissertations about the risk of recurrent positive. The aim of this study was to explore the relationship between SARS-COV-2 RNA positive duration (SPD) and the risk of recurrent positive. Methods This case–control multi-center study enrolled participants from 8 Chinese hospital including 411 participants (recurrent positive 241). Using unadjusted and multivariate-adjusted logistic regression analyses, generalized additive model with a smooth curve fitting, we evaluated the associations between SPD and risk of recurrent positive. Besides, subgroup analyses were performed to explore the potential interactions. Results Among recurrent positive patients, there were 121 females (50.2%), median age was 50 years old [interquartile range (IQR): 38–63]. In non-adjusted model and adjusted model, SPD was associated with an increased risk of recurrent positive (fully-adjusted model: OR = 1.05, 95% CI: 1.02–1.08, P = 0.001); the curve fitting was not significant (P = 0.286). Comparing with SPD < 14 days, the risk of recurrent positive in SPD > 28 days was risen substantially (OR = 3.09, 95% CI: 1.44–6.63, P = 0.004). Interaction and stratified analyses showed greater effect estimates of SPD and risk of recurrent positive in the hypertension, low monocyte count and percentage patients (P for interaction = 0.008, 0.002, 0.036, respectively). Conclusion SPD was associated with a higher risk of recurrent positive and especially SPD > 28 day had a two-fold increase in the relative risk of re-positive as compared with SPD < 14 day. What’s more, the risk may be higher among those with hypertension and lower monocyte count or percentage.

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Section: Discussionsupporting

confidence: 91%

The relationship between SARS-COV-2 RNA positive duration and the risk of recurrent positive

et al. 2021

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“…Upon hospital readmission, these RP patients showed no obvious symptoms or disease progression. All close contacts of RP patients tested negative and showed no suspicious symptoms Tang et al [118] China Case series 14 8 28 (IQR 20–38) 22/209 – 9 positive 13 positive – – Re-positive test was significantly associated with older age (OR=0·95, 95%CI 0·93−0·98) and diarrhea during hospital stage (OR=10·44, 95%CI 1·60−68·16) Hao et al [111] China Case series 12 11 – 23/369 – positive positive – – Results indicated that albumin/globulin ratio may potentially have a predictive effect in “re-positive” discharged COVID-19 patients Wang et al [124] China Cohort study 4 4 46·5 8/131 7–14 d positive – – – (RP for RT-PCR is not the measurement outcome of this cohort study.) All 8 RP patients were asymptomatic at the time of discharge.…”

Section: Resultsmentioning

confidence: 99%

A systematic review and meta-analysis of discharged COVID-19 patients retesting positive for RT-PCR

Ren

Lou

et al. 2021

EClinicalMedicine

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Background With the increased number of patients discharged after having COVID-19, more and more studies have reported cases whose retesting was positive (RP) during the convalescent period, which brings a new public health challenge to the world. Methods We searched PubMed, Web of Science, The Cochrane Library, CNKI, WanFang and VIP from December 1, 2019 to December 31, 2020. The included studies were assessed using JBI critical appraisal tools and Newcastle-Ottawa Scale. The RP rate of discharge patients was analyzed by a meta-analysis. We adhered to PRISMA reporting guideline. Findings We have included 117 studies with 2669 RP participants after discharge. The methodological quality of 66 case reports were low to high, 42 case series and 3 cohort study were moderate to high, 3 case-control studies were moderate and 3 cross-sectional studies were low to moderate. The clinical manifestations of most RP patients were mild or asymptomatic, and CT imaging and laboratory examinations were usually normal. The existing risk factors suggest that more attention should be paid to sever patients, elderly patients, and patients with co-morbidities. The summary RP rate was 12·2% (95% CI 10·6–13·7) with high heterogeneity ( I 2 = 85%). Interpretation To date, the causes and risk factors of RP result in discharged patients are not fully understood. High-quality etiological and clinical studies are needed to investigate these issues to further help us to make strategies to control and prevent its occurrence.

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“…The basic characteristics of the included articles are summarized in Table 1 . Out of the 34 included articles, 33 were from China [ 12 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ] and 1 from Italy [ 30 ]. All of the included studies were conducted during the first wave of the COVID-19 pandemic.…”

Section: Resultsmentioning

confidence: 99%

Immunoglobulin Response and Prognostic Factors in Repeated SARS-CoV-2 Positive Patients: A Systematic Review and Meta-Analysis

Dembrovszky

Váncsa

Farkas

et al. 2021

Viruses

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With repeated positivity being an undiscovered and major concern, we aimed to evaluate which prognostic factors may impact repeated SARS-CoV-2 positivity (RSP) and their association with immunoglobulin detectability among recovered patients. A systematic literature search was performed on 5 April 2021. Cohort studies with risk factors for repeated RSP or information about the immunoglobulin response (immunoglobulin M (IgM) and/or immunoglobulin G (IgG)) were included in this analysis. The main examined risk factors were severity of the initial infection, body mass index (BMI), length of hospitalization (LOH), age, and gender, for which we pooled mean differences and odds ratios (ORs). Thirty-four cohort studies (N = 9269) were included in our analysis. We found that increased RSP rate might be associated with IgG positivity; IgG presence was higher in RSP patients (OR: 1.72, CI: 0.87–3.41, p = 0.117). Among the examined risk factors, only mild initial disease course showed a significant association with RSP (OR: 0.3, CI: 0.14–0.67, p = 0.003). Age, male gender, BMI, LOH, and severity of the first episode do not seem to be linked with repeated positivity. However, further prospective follow-up studies focusing on this topic are required.

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<p>The Role of Albumin/Globulin Ratio in Discharged COVID-19 Patients with Re-Positive Nucleic Acid Detection</p>

Cited by 4 publications

References 6 publications

The relationship between SARS-COV-2 RNA positive duration and the risk of recurrent positive

The relationship between SARS-COV-2 RNA positive duration and the risk of recurrent positive

A systematic review and meta-analysis of discharged COVID-19 patients retesting positive for RT-PCR

Immunoglobulin Response and Prognostic Factors in Repeated SARS-CoV-2 Positive Patients: A Systematic Review and Meta-Analysis

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