&lt;p&gt;The Role of Inhaled Anesthetics in Tumorigenesis and Tumor Immunity&lt;/p&gt;

Xu, Yichi; Jiang, Wenxiao; Xie, Shangdan; Xue, Fang; Zhu, Xueqiong

doi:10.2147/cmar.s244280

Cited by 19 publications

(11 citation statements)

References 67 publications

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“…The dynamic changes in PBMCs during the perioperative period differed according to the route of anaesthesia. The effect of different anaesthetics on immunity has been the focus of substantial body of anaesthesiology research 32,33 . Studies have been conducted on patients’ immune status 34–36 .…”

Section: Discussionmentioning

confidence: 99%

“…The effect of different anaesthetics on immunity has been the focus of substantial body of anaesthesiology research. 32 , 33 Studies have been conducted on patients’ immune status. 34 , 35 , 36 Other investigation has explored whether anaesthesia can inhibit the immune response of patients with cancer, thereby affecting their long‐term outcomes.…”

Section: Discussionmentioning

confidence: 99%

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An atlas of dynamic peripheral blood mononuclear cell landscapes in human perioperative anaesthesia/surgery

Wang

Chang

Zhu

et al. 2022

Clinical & Translational Med

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Background The number of patients receiving anaesthesia is increasing, but the impact of general anaesthesia on the patient's immune system remains unclear. The aim of the present study is to investigate dynamics of systemic immune cell responses to anaesthesia during perioperative period at a single‐cell solution. Methods The peripheral blood mononuclear cells (PBMCs) and clinical phenomes were harvested and recorded 1 day before anaesthesia and operation, just after anaesthesia (0 h), and 24 and 48 h after anaesthesia. Single‐cell sequencing of PBMCs was performed with 10× genomics. Subsequently, data analysis was performed with R packages: Seurat, clusterProfiler and CellPhoneDB. Results We found that the cluster of CD56+ NK cells changed at 0 h and the cluster of monocytes increased at 24 and 48 h after anaesthesia. The characteristic genes of CD56+ NK cells were mainly enriched in the Jak‐STAT signalling pathway and in cell adhesion molecules (24 h) and carbon metabolism (48 h). The communication between CD14+ monocytes and other cells decreased substantially 0 and 48 h after operation. The number of plasma cells enriched in protein export in men was substantially higher than that in women, although the total number in patients decreased 24 h after operation. CD14+ monocytes dominated that cell‐cell communications appeared in females, while CD8+ NKT cells dominated that cell‐cell communications appeared in male. The number of plasma cells increased substantially in patients with major surgical trauma, with enrichments of pentose phosphate pathway. The communications between plasma cells with other cells varied between surgical severities and anaesthetic forms. The intravenous anaesthesia caused major alterations of cell types, including CD14+ monocytes, plasmas cells and MAIT cells, as compared with inhalation anaesthesia. Conclusion We initially reported the roles of perioperative anaesthesia/surgery in temporal phenomes of circulating immune cells at a single‐cell solution. Thus, the protection against immune cell changes would benefit the recovery from anaesthesia/surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

An atlas of dynamic peripheral blood mononuclear cell landscapes in human perioperative anaesthesia/surgery

Wang

Chang

Zhu

et al. 2022

Clinical & Translational Med

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“…The study has shown that various surgical procedures may increase the chances of invasion and migration of cancer cells; hence, it promotes their ability to disseminate in that duration [ 9 ]. Hence, treatment with desflurane, isoflurane, and sevoflurane [ 10 , 11 ] plays a crucial role in reducing the tumor recurrence postsurgery. It is crucial to choose the appropriate anesthetic for the surgical process in operating a tumor.…”

Section: Discussionmentioning

confidence: 99%

Molecular Mechanism of Gas Anesthetics on the Invasion, Metastasis, and Chemosensitivity of Osteosarcoma Cells

Zhao

Yan

et al. 2021

Computational and Mathematical Methods in Medicine

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Background. Osteosarcoma is one of the most prominent bone cancers which has a predominant occurrence in children and adolescents. This study is focused on determining the effects of treatment of gas anesthetics on invasion, metastasis, and chemosensitivity in the progression of osteosarcoma cells. Material and Methods. The biological effects of the common gas anesthetics—desflurane, isoflurane, and sevoflurane—on osteosarcoma cells were studied and compared. The biological assays were performed for analysis of cell migration and proliferation. Results. Isoflurane and sevoflurane have shown significant inhibition in the osteosarcoma cells at clinically relevant concentrations. Desflurane has shown less potent action on cell migration and inhibition. All three gas anesthetics have shown inhibition in cell proliferation. The effective antiproliferative action was at a clinically significant dose. At low millimolar concentrations, cell apoptosis was moderately affected. Drug combination analysis with chemotherapeutic drugs showed relevant inhibition in cell migration. All three agents showed significant augmentation of chemotherapeutic drugs in suppression and inhibition of inducing apoptosis. The antimigration action is likely to affect the PI3K/AKT pathway and IGF-1. Conclusion. The study demonstrates the proposed mechanisms of gas anesthetics and their differential effects on osteosarcoma cells and their survival, migration, growth, and chemosensitivity.

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“…The increasing interest in the impact of anesthetics and cancer progression has stimulated several in vivo and in vitro studies on the relation between different kinds of anesthetics used during surgery and cancer development Brogi and Forfori J Anesth Analg Crit Care (2022) 2: 33 and progression [48,62]. Even if the evidence is conflicting, halogenated anesthetics seemed to present several pro-inflammatory and immunosuppressive effects that can have an important impact on enhancing metastasis formation [63]. Volatile anesthetic agents are implied in the upregulation of hypoxia-inducible factors [64].…”

Section: Anesthetic Agents Volatile and Intravenous Anestheticsmentioning

confidence: 99%

Anesthesia and cancer recurrence: an overview

Brogi

Forfori

2022

J Anesth Analg Crit Care

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Several perioperative factors are responsible for the dysregulation or suppression of the immune system with a possible impact on cancer cell growth and the development of new metastasis. These factors have the potential to directly suppress the immune system and activate hypothalamic-pituitary-adrenal axis and the sympathetic nervous system with a consequent further immunosuppressive effect.Anesthetics and analgesics used during the perioperative period may modulate the innate and adaptive immune system, inflammatory system, and angiogenesis, with a possible impact on cancer recurrence and long-term outcome. Even if the current data are controversial and contrasting, it is crucial to increase awareness about this topic among healthcare professionals for a future better and conscious choice of anesthetic techniques.In this article, we aimed to provide an overview regarding the relationship between anesthesia and cancer recurrence. We reviewed the effects of surgery, perioperative factors, and anesthetic agents on tumor cell survival and tumor recurrence.

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<p>The Role of Inhaled Anesthetics in Tumorigenesis and Tumor Immunity</p>

Cited by 19 publications

References 67 publications

An atlas of dynamic peripheral blood mononuclear cell landscapes in human perioperative anaesthesia/surgery

An atlas of dynamic peripheral blood mononuclear cell landscapes in human perioperative anaesthesia/surgery

Molecular Mechanism of Gas Anesthetics on the Invasion, Metastasis, and Chemosensitivity of Osteosarcoma Cells

Anesthesia and cancer recurrence: an overview

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