<p>The role of low density lipoprotein receptor-related protein 11 as a tumor promoter in cervical cancer</p>

Abstract

Background It is unclear whether low density lipoprotein receptor-related protein 11 (LRP11), a newly found lipoprotein receptor regulatory protein, has the carcinogenic effects in cervical cancer. Methods Bioinformatics analysis, immunohistochemical (IHC) staining and evaluation, cell proliferation assay, flow cytometry, transwell migration and invasion assays, Western blotting, growth of LRP11-silenced cells in athymic nude mice were performed in this research. Results We found that LRP11 expression was higher in high-grade squamous intraepithelial lesions (HSIL) and cervical cancer tissue than in normal cervix, and high expression of LRP11 was associated with differentiation degree ( P =0.0266), indicating poor prognosis ( P =0.0210). The silencing of LRP11 in SiHa and CaSki cell lines inhibited cell proliferation, reduced migration and invasion and suppressed cell growth in nude mice, which possibly related to cell cycle protein regulation of CDK 2/4, cyclin D1/E1, MMP-2/9, and VEGF. Furthermore, LRP11 showed substantial positive correlation with P16 in vivo and in vitro. Conclusion LRP11 plays important roles in proliferation, migration and invasion, with the potential to be a useful prognostic marker and therapeutic target for patients with HSIL and cervical cancer.

The Plasma DIA-Based Quantitative Proteomics Reveals the Pathogenic Pathways and New Biomarkers in Cervical Cancer and High Grade Squamous Intraepithelial Lesion

“…In addition, the cholesterol metabolism pathway was also on the list in CC vs. HSIL and HSIL vs. CK groups. This is also in line with our previous studies of related pathway molecules such as LRP11 and other studies [ 27 , 28 ].…”

<p>Effects of LRP1B Regulated by HSF1 on Lipid Metabolism in Hepatocellular Carcinoma</p>

“…cell lung cancer (NSCLC), 45 thyroid cancer, 46 cervical cancer 47 and melanoma, 48 and identified LRP1B as a potential tumor suppressor in these cancers. Intriguingly, in contrast to the cancers mentioned above, HCC presents a predominantly strong expression of LRP1B.…”

USP16 Regulates the Stability and Function of LDL receptor by Deubiquitination

“…20) The role of LDLR elated protein as a tumor promoter in cervical cancer has been reported. 24) The utilization of LDL to deliver cytotoxic drugs to tumor cells has been studied since the 1980s, when several cancer cell lines were found to have higher LDLR activity than normal cells. Such differential uptake between tumor cells and normal cells may provide a special opportunity to use LDL as a tumor-specific carrier for the clinical treatment of cancer cells.…”