&lt;p&gt;The Role of PPARδ Agosnist GW501516 in Rats with Gestational Diabetes Mellitus&lt;/p&gt;

Zhou, Jun; Zhe, Ruilian; X, Guo; Chen, Yuying; Zou, Yan; Zhou, Li; Wang, Zhijian

doi:10.2147/dmso.s251491

Cited by 9 publications

(5 citation statements)

References 28 publications

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“…Furthermore, the number of arterial plaques, intima thickness, macrophage activation and α-SMA expression in DM-AS rats were increased compared with those in the control rats, indicating the successful establishment of the DM-AS model. It was found that the normal blood glucose level of rats is ~4 mmol/l (27), similar to the results observed in the present study .…”

Section: Discussionsupporting

confidence: 92%

Gycyrrhizic acid alleviates atherosclerotic lesions in rats with diabetes mellitus

Zhao

Zhang

2021

Mol Med Rep

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Gycyrrhizic acid (GA), an inhibitor of high mobility group box 1 (HMGB1), inhibits inflammatory responses and is involved in the occurrence and development of several inflammation-related diseases. However, the role of GA in the atherosclerotic lesions caused by diabetes mellitus (DM) remains unknown. In the present study, Sprague Dawley rats were selected to desi=gn a diabetic atherosclerosis (AS) model. Rats from the DM-AS group were subsequently divided into DM-AS, DM-AS + GA (50 mg/kg) and DM-AS + GA (150 mg/kg) groups. Biochemical analyzers were used to measure levels of blood glucose, fasting insulin, total cholesterol, total triglyceride, low-density lipoprotein and high-density lipoprotein. The number of plaques was recorded after collection of thoracic aortas from the rats. The intimal thickness of arterial tissue was detected by hematoxylin and eosin staining. The expression levels of CD68 and α-smooth muscle actin (α-SMA) were detected by immunohistochemistry. The expression of tumor necrosis factor-α, interleukin (IL)-6 and IL-1β in the serum of the rats was detected by ELISA. The expression of fatty acid synthetase, sterol regulatory element binding protein 1C, HMGB1 and receptor for advanced glycation end products (RAGE) was detected by western blotting. Reverse transcription quantitative PCR was used to detect the mRNA expression of HMGB1 and RAGE. The results demonstrated that GA treatment could decrease the body weight, blood glucose level and biochemical parameters of AS DM rats in a dose-dependent manner. In addition, GA decreased the intimal thickness of carotid artery and the formation of plaque in rats with diabetic AS. Furthermore, GA inhibited macrophage activation and decreased α-SMA expression in vascular smooth muscle cells, and decreased the expression of proteins (FAS and SREBP-1c) and inflammatory factors. Taken together, the findings from the present study demonstrated that GA may have a therapeutic effect on DM-associated AS. This study provides a theoretical basis for the treatment of diabetic AS.

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Section: Discussionsupporting

confidence: 92%

Gycyrrhizic acid alleviates atherosclerotic lesions in rats with diabetes mellitus

Zhao

Zhang

2021

Mol Med Rep

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“…PPARs (PPARα, PPARβ/δ and PPARγ) promote lipolysis, enhance insulin sensitivity and reduce blood lipid levels, and has the properties of cardiovascular protection [81][82][83]. Generally, PPARs are low-expressed in patients with obesity and T2DM [84,85]. PPARγ agonists, thiazolidinediones, are widely used in clinics as insulin sensitizers.…”

Section: Discussionmentioning

confidence: 99%

C Allele of the PPARδ+294T>C Polymorphism Confers a Higher Risk of Hypercholesterolemia, but not Obesity and Insulin Resistance: A Systematic Review and Meta-Analysis

Zhang

et al. 2023

Horm Metab Res

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The relationships of the PPARα Leu162Val and PPARδ+294 T>C polymorphisms with metabolic indexes have been reported to be inconsistent and even contradictory. The meta-analysis was conducted to clarify the relationships between the two variants and the indexes of obesity, insulin resistance, and blood lipids. PubMed, Google Scholar, Embase, and Cochrane Library were searched for eligible studies. Standardized mean difference with 95% confidence interval was calculated to estimate the differences in the metabolic indexes between the genotypes of the Leu162Val and+294 T>C polymorphisms. Heterogeneity among studies was assessed by Cochran’s x2-based Q-statistic test. Publication bias was identified by using Begg’s test. Forty-one studies (44 585 subjects) and 33 studies (23 018 subjects) were identified in the analyses for the Leu162Val and+294 T>C polymorphisms, respectively. C allele carriers of the+294 T>C polymorphism had significantly higher levels of total cholesterol and low-density lipoprotein cholesterol than TT homozygotes in the whole population. Notably, C allele carriers of the+294 T>C polymorphism had significantly higher levels of triglycerides and total cholesterol in East Asians, but lower levels of triglycerides in West Asians than TT homozygotes. Regarding the Leu162Val polymorphism, it was found that Val allele carriers had significantly higher levels of blood glucose than Leu/Leu homozygotes only in European Caucasians. The meta-analysis demonstrates that C allele of the+294 T>C polymorphism in PPARδ gene confers a higher risk of hypercholesterolemia, which may partly explain the relationship between this variant and coronary artery disease.

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“…Angiopoietin-like protein 8 (Angptl 8) is a newly identified protein factor whose secretion is closely related to lipid metabolism, insulin sensitivity, and glucose metabolism ( 90 ). Angptl8 can influence plasma lipoprotein levels by regulating IR and glucose homeostasis ( 98 ). JNK signaling pathway inhibition by ANGPTL8 knockdown can enhance insulin sensitivity in trophoblast cells.…”

Section: Gestational Diabetes and Metabolic Reprogrammingmentioning

confidence: 99%

Recent progress in metabolic reprogramming in gestational diabetes mellitus: a review

Xie,

Lin,

Xie

et al. 2024

Front. Endocrinol.

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Gestational diabetes mellitus is a prevalent metabolic disease that can impact the normal course of pregnancy and delivery, leading to adverse outcomes for both mother and child. Its pathogenesis is complex and involves various factors, such as insulin resistance and β-cell dysfunction. Metabolic reprogramming, which involves mitochondrial oxidative phosphorylation and glycolysis, is crucial for maintaining human metabolic balance and is involved in the pathogenesis and progression of gestational diabetes mellitus. However, research on the link and metabolic pathways between metabolic reprogramming and gestational diabetes mellitus is limited. Therefore, we reviewed the relationship between metabolic reprogramming and gestational diabetes mellitus to provide new therapeutic strategies for maternal health during pregnancy and reduce the risk of developing gestational diabetes mellitus.

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<p>The Role of PPARδ Agosnist GW501516 in Rats with Gestational Diabetes Mellitus</p>

Cited by 9 publications

References 28 publications

Gycyrrhizic acid alleviates atherosclerotic lesions in rats with diabetes mellitus

Gycyrrhizic acid alleviates atherosclerotic lesions in rats with diabetes mellitus

C Allele of the PPARδ+294T>C Polymorphism Confers a Higher Risk of Hypercholesterolemia, but not Obesity and Insulin Resistance: A Systematic Review and Meta-Analysis

Recent progress in metabolic reprogramming in gestational diabetes mellitus: a review

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