<p>The Role of Prefoldin and Its Subunits in Tumors and Their Application Prospects in Nanomedicine</p>

Abstract

Prefoldin (PFDN) is a hexameric chaperone complex that is widely found in eukaryotes and archaea and consists of six different subunits (PFDN1-6). Its main function is to transfer actin and tubulin monomers to the eukaryotic cell cytoplasmic chaperone protein (c-CPN) specific binding during the assembly of the cytoskeleton, to stabilize the newly synthesized peptides so that they can be folded correctly. The current study found that each subunit of PFDN has different functions, which are closely related to the occurrence, development and prognosis of tumors. However, the best characteristics of each subunit have not been fully affirmed. The connection between research and tumors can change the understanding of PFDN and further extend its potential prognostic role and structural function to cancer research and clinical practice. This article mainly reviews the role of canonical PFDN and its subunits in tumors and other diseases, and discusses the potential prospects of the unique structure and function of PFDN in nanomedicine.

Prefoldin Subunits and Its Associate Partners: Conservations and Specificities in Plants

“…Plant CCT deficient cells exhibited depletion of cortical microtubules, accompanied by reduced tubulin level due to protein degradation [ 58 ], which is similar to the disorganized arrangement of tubulin in the PFD gene depletion mutants [ 13 , 18 , 29 , 34 ]. Moreover, prefoldin subunits also involved in the pathogenesis of human neurodegenerative diseases and tumors [ 7 , 9 , 59 ], which reveals the tightly correlation with CCT. Thus, PFD-CCT could be the conserved module in controlling the protein folding for proteostasis in organisms, both in mammals and plants.…”

Identification and Validation of Key Genes of Differential Correlations in Gastric Cancer

“…PFDN2 belongs to the prefoldin subunits family which can bind and stabilize newly synthesized polypeptides (Mo et al, 2020). In GC, high mRNA expression of PFDN2 displayed poor OS (Yesseyeva et al, 2020).…”

Prefoldin 6 promotes glioma progression via the AKT signalling pathway

“…cytosolic chaperonin (c-CPN) and transfers target proteins to it, simultaneously promoting precise protein folding (Mo et al, 2020).…”

“…Prefoldin (PFDN) is a heteromeric prefoldin complex composed of six different subunits (PFDN1‐6). PFDN primarily binds to cytosolic chaperonin (c‐CPN) and transfers target proteins to it, simultaneously promoting precise protein folding (Mo et al, 2020). PFDN has been associated with tumour progression, and each subunit of PFDN performs different functions (Yesseyeva et al, 2020; Zhou et al, 2020).…”