&lt;p&gt;The Significance of CXCL1 and CXCL8 as Well as Their Specific Receptors in Colorectal Cancer&lt;/p&gt;

Łukaszewicz-Zając, Marta; Pączek, Sara; Mroczko, Piotr; Kulczyńska-Przybik, Agnieszka

doi:10.2147/cmar.s267176

Cited by 29 publications

(23 citation statements)

References 83 publications

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“…According to previous studies, the TME in CRC contains a rich cytokine/chemokine milieu regulating tumorigenesis (21). Strikingly, the expression of DC activation gene signatures, such as CD80, CD83, and CD86 was positively correlated with CXCL8 expression (Figure 3C).…”

Section: Identification Of Cxcl8 As a Key Regulator In Immune-mediated Crcsupporting

confidence: 63%

CXCL8 Associated Dendritic Cell Activation Marker Expression and Recruitment as Indicators of Favorable Outcomes in Colorectal Cancer

Yang

et al. 2021

Front. Immunol.

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Accumulating evidence suggests that tumor-infiltrating immune cells (TICs) in the tumor microenvironment (TME) serve as promising therapeutic targets. CXCL8 (IL-8) may also be a potential therapeutic target in cancer. CXCL8 is a potent chemotactic factor for neutrophils, myeloid-derived suppressor cells (MDSCs) and monocytes, which are considered immunosuppressive components in cancer-bearing hosts. Here, we identified the TME-related gene CXCL8 in a high-ImmuneScore population that contributed to better survival in colorectal cancer (CRC) patients from The Cancer Genome Atlas (TCGA) database. An integrated gene profile and functional analysis of TIC proportions revealed that the dendritic cell (DC) activation markers CD80, CD83, and CD86 were positively correlated with CXCL8 expression, suggesting that CXCL8 may be functional as antitumor immune response status in the TME. The gene signature was further validated in independent GSE14333 and GSE38832 cohorts from the Gene Expression Omnibus (GEO). To test the differential contributions of immune and tumor components to progression, three CRC cell lines, CT26, MC38 and HCT116, were used. In vitro results suggested no significant growth or survival changes following treatment with an inhibitor of the CXCL8 receptor (CXCR1/2) such as reparixin or danirixin. In vivo treatment with danirixin (antagonists of CXCR2) promoted tumor progression in animal models established with CT26 cells. CXCR2 antagonism may function via an immune component, with CXCR2 antagonist treatment in mice resulting in reduced activated DCs and correlating with decreased Interferon gamma (IFN-γ) or Granzyme B expressed CD8+ T cells. Furthermore, CXCL8 induced DC migration in transwell migration assays. Taken together, our data suggested that targeting the CXCL8-CXCR2 axis might impede DC activation or recruitment, and this axis could be considered a favorable factor rather than a target for critical antitumor effects on CRC.

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Section: Identification Of Cxcl8 As a Key Regulator In Immune-mediated Crcsupporting

confidence: 63%

CXCL8 Associated Dendritic Cell Activation Marker Expression and Recruitment as Indicators of Favorable Outcomes in Colorectal Cancer

Yang

et al. 2021

Front. Immunol.

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“…The CXC family of chemokines attract neutrophils and lymphocytes, which are activated by binding of these chemokines to appropriate receptors ( 31 ). As a neutrophil marker, CXCL1 binds to its receptor CXCR2, playing a crucial role in the host immune response by recruiting and activating neutrophils and inducing neutrophil migration ( 32 ). Thus, identification of novel neutrophil biomarkers that enable early and accurate detection of neutrophil dysfunction is needed for timely prognosis of patients with HBV-ACLF.…”

Section: Discussionmentioning

confidence: 99%

Serum CXCL1 Is a Prognostic Factor for Patients With Hepatitis B Virus–Related Acute-On-Chronic Liver Failure

et al. 2021

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Purpose: Neutrophils and cytokines play a major role in the pathogenesis of acute-on-chronic liver failure (ACLF). We aimed to determine whether chemokine (CXC) ligand 1 (CXCL1), a key marker of neutrophil recruitment and activation, could predict the severity and prognosis of hepatitis B virus–related ACLF (HBV-ACLF).Methods: Hospitalized patients with HBV-ACLF were enrolled in a prospective study and stratified as survivors (alive at 28 days) and nonsurvivors (deceased at 28 days). Serum CXCL1 levels were measured in healthy controls, patients with chronic HBV, patients with HBV-related compensated cirrhosis, and patients with HBV-ACLF. Univariate and multivariable logistic analyses, Pearson correlation analysis, area under the receiver operating characteristic curve (AUROC), and Z tests were used to evaluate the performance of CXCL1 as a marker in HBV-ACLF.Results: Patients with HBV-ACLF had significantly higher serum levels of CXCL1 and neutrophil count than healthy controls and patients with chronic HBV or HBV-related compensated cirrhosis (P < 0.01, respectively). Among patients with HBV-ACLF, survivors had lower serum CXCL1 levels and neutrophil count than those of nonsurvivors (P < 0.001, P < 0.05, respectively). Serum CXCL1 level was positively correlated with neutrophil count (r = 0.256, P = 0.001), ACLF grade (r = 0.295, P < 0.001) and organ failure, including coagulation (r = 0.21, P = 0.005) and brain failure (r = 0.198, P = 0.008). Multivariable logistic analyses showed serum CXCL1 [OR (95% CI) = 1.017 (1.009–1.025), P < 0.001] was an independent risk factor for 28-day mortality in HBV-ACLF. Meanwhile, the AUROC analysis demonstrated that serum CXCL1 [0.741 (0.669–0.804)] might be a reliable prognostic biomarker for patients with HBV-ACLF.Conclusions: Overall, serum CXCL1 can serve as a biomarker indicating the severity of disease and prognosis for patients with HBV-ACLF. CXCL1 might also be a therapeutic target in this disease.

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“…In this study, the screened genes included CXCL8, GLRB, CD180, TMOD2, AFP, ALB, RASSF6, AMBN, CSN2, CSN3, DMTF1, IGFBP7, IMPAD1, NAP1l4, NPY1R, ODAM, SLC4A4, WDR5, and AFM. Among those genes, CXCL8(Wang et al2020;UkaszewiczZajc et al2020), CD180(Dong et al2019), AFP(B et al2020), RASSF6(Vogel et al2020), and IGFBP7 have been proved to be related to immune diseases, and these genes are closely related to human diseases. For example, CXCL8 is a chemokine which is expressed in a variety of tissues.…”

Section: Discussionmentioning

confidence: 99%

The Population Structure and Selection Signal Analysis of Shenxian Pigs based on Genome Resequencing Technology

Liu

et al. 2021

Preprint

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Shenxian pigs are the only local black pig of Hebei Province, and were listed in the Genetics of Livestock and Poultry Resources of China in 2016. This breed of pig is considered to be a valuable local pig germplasm genetic resource in China. In the present study, in order to understand the genetic variations of Shenxian pigs, identify selected regions related to superior traits, and accelerate the breeding processes of Shenxian pigs, the whole genome of the Shenxian pigs was resequenced and compared with that of large white pigs. The goal was to explore the germplasm characteristics of Shenxian pigs.The results obtained in this research investigation revealed that the genetic relationships of the Shenxian pig breed were complex, and that sub-populations could be identified within the general population. A total of 23M SNP sites were obtained by whole genome resequencing, and 1,509 selected sites were obtained via bioinformatics analyses. It was determined after annotation that a total of 19 genes were enriched in three items of bioengineering, molecular function, and cell composition.During this research investigation, the aforementioned 19 genes were subjected to GO and KEGG analyses. Subsequently, the candidate genes related to cell proliferation were obtained (DMTF1 and WDR5), which were considered to possibly be related to the slow growth and development of Shenxian pigs. In addition, the candidate genes related to lactation were obtained (CSN2 and CSN3).

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<p>The Significance of CXCL1 and CXCL8 as Well as Their Specific Receptors in Colorectal Cancer</p>

Cited by 29 publications

References 83 publications

CXCL8 Associated Dendritic Cell Activation Marker Expression and Recruitment as Indicators of Favorable Outcomes in Colorectal Cancer

CXCL8 Associated Dendritic Cell Activation Marker Expression and Recruitment as Indicators of Favorable Outcomes in Colorectal Cancer

Serum CXCL1 Is a Prognostic Factor for Patients With Hepatitis B Virus–Related Acute-On-Chronic Liver Failure

The Population Structure and Selection Signal Analysis of Shenxian Pigs based on Genome Resequencing Technology

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