&lt;p&gt;Toxicity screening of two prevalent metal organic frameworks for therapeutic use in human lung epithelial cells&lt;/p&gt;

Wagner, Alixandra; Liu, Qian; Rose, Olivia L.; Eden, Anna; Vijay, Aishwarya; Rojanasakul, Yon; Dinu, Cerasela Zoica

doi:10.2147/ijn.s215950

Cited by 37 publications

(16 citation statements)

References 49 publications

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“…The same trend was observed in studies of the correlation between the MOF hydrophobicity and their toxicity towards human lung epithelial cells. It was shown that the hydrophobic ZIF-8 particles were more toxic than the hydrophilic MIL-160 particles [ 23 ] (IC 50 values were 61 µg/mL and 433 µg/mL, respectively). At the same time, some of the observed MOF particles demonstrate moderate or high toxicity to a live system.…”

Section: Introductionmentioning

confidence: 99%

Acute Toxicity of Cu-MOF Nanoparticles (nanoHKUST-1) towards Embryos and Adult Zebrafish

Abramenko

Deyko

Abkhalimov

et al. 2021

IJMS

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Metal-organic frameworks (MOFs) demonstrate unique properties, which are prospective for drug delivery, catalysis, and gas separation, but their biomedical applications might be limited due to their obscure interactions with the environment and humans. It is important to understand their toxic effect on nature before their wide practical application. In this study, HKUST-1 nanoparticles (Cu-nanoMOF, Cu3(btc)2, btc = benzene-1,3,5-tricarboxylate) were synthesized by the microwave (MW)-assisted ionothermal method and characterized by X-ray powder diffraction (XRD) and transmission electron microscopy (TEM) techniques. The embryotoxicity and acute toxicity of HKUST-1 towards embryos and adult zebrafish were investigated. To gain a better understanding of the effects of Cu-MOF particles towards Danio rerio (D. rerio) embryos were exposed to HKUST-1 nanoparticles (NPs) and Cu2+ ions (CuSO4). Cu2+ ions showed a higher toxic effect towards fish compared with Cu-MOF NPs for D. rerio. Both forms of fish were sensitive to the presence of HKUST-1 NPs. Estimated LC50 values were 2.132 mg/L and 1.500 mg/L for zebrafish embryos and adults, respectively. During 96 h of exposure, the release of copper ions in a stock solution and accumulation of copper after 96 h were measured in the internal organs of adult fishes. Uptake examination of the major internal organs did not show any concentration dependency. An increase in the number of copper ions in the test medium was found on the first day of exposure. Toxicity was largely restricted to copper release from HKUST-1 nanomaterials structure into solution.

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Section: Introductionmentioning

confidence: 99%

Acute Toxicity of Cu-MOF Nanoparticles (nanoHKUST-1) towards Embryos and Adult Zebrafish

Abramenko

Deyko

Abkhalimov

et al. 2021

IJMS

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“…These outcomes are shown in Figure 9. This study demonstrated the importance of screening toxicity before biomedical applications of MOFs [47].…”

Section: Biocompatibilitymentioning

confidence: 69%

“…Indeed, MOF biocompatibility is affected by the type of metal and ligand used in MOF structure. MOF physicochemical properties such as particle size, structure, and hydrophobicity can also be effective on MOF biocompatibility [34,36,47]. [41]).…”

Section: Biocompatibilitymentioning

confidence: 99%

An investigation of affecting factors on MOF characteristics for biomedical applications: A systematic review

Ahmadi

Ayyoubzadeh

Ghorbani‐Bidkorbeh

et al. 2021

Heliyon

101

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Metal-organic frameworks (MOFs) are a fascinating class of crystalline porous materials composed of metal ions and organic ligands. Due to their attractive properties, MOFs can potentially offer biomedical field applications, such as drug delivery and imaging. This study aimed to systematically identify the affecting factors on the MOF characteristics and their effects on structural and biological characteristics. An electronic search was performed in four databases containing PubMed, Scopus, Web of Science, and Embase, using the relevant keywords. After analyzing the studies, 20 eligible studies were included in this review. As a result, various factors such as additives and organic ligand can influence the size and structure of MOFs. Additives are materials that can compete with ligand and may affect the nucleation and growth processes and, consequently, particle size. The nature and structure of ligand are influential in determining the size and structure of MOF. Moreover, synthesis parameters like the reaction time and initial reagents ratio are critical factors that should be optimized to regulate the size and structure. Of note is that the nature of the ligand and using a suitable additive can control the porosity of MOF. The more extended ligands aid in forming large pores. The choice of metallic nodes and organic ligand, and the MOF concentration are important factors since they can determine toxicity and biocompatibility of the final structure. The physicochemical properties of MOFs, such as hydrophobicity, affect the toxicity of nanoparticles. An increase in hydrophobicity causes increased toxicity of MOF. The biodegradability of MOF, as another property, depends on the organic ligand and metal ion and environmental conditions like pH. Photocleavable ligands can be served for controlled degradation of MOFs. Generally, by optimizing these affecting factors, MOFs with desirable properties will be obtained for biomedical applications.

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“…Wagner et al [414] tested in a model-way the toxicity of a MIL-160, a microporous hydrophilic aluminium-based MOF with a five-membered ring and an oxygen heteroatom, and ZIF-8, a hydrophobic framework of zeolitic imidazolate on the human bronchial epithelial (BEAS-2B) cells.…”

Section: Separatorsmentioning

confidence: 99%

The Toxicity of Secondary Lithium-Sulfur Batteries Components

Siczek

2020

Batteries

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Currently, apart from the widely known lithium-ion batteries, there are competitive solutions in the form of, for example, Li-S batteries. While the results of studies on the toxicity of Li-ion battery components are published, such studies on the components of Li-S cells are just beginning. The purpose of the current review was to identify materials used in the production of Li-S batteries and their toxicity, especially for humans. The review showed many kinds of materials with different levels of toxicity utilized for manufacturing of these cells. Some materials are of low toxicity, while some others are of the high one. A lot of materials have assigned different hazard statements. For some of the materials, no hazard statements were assigned, although such materials are toxic. No data related to the toxicity of some materials were found in the literature. This points out the need to further studies on their toxicity and legal actions to assign appropriate hazard statements.

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<p>Toxicity screening of two prevalent metal organic frameworks for therapeutic use in human lung epithelial cells</p>

Cited by 37 publications

References 49 publications

Acute Toxicity of Cu-MOF Nanoparticles (nanoHKUST-1) towards Embryos and Adult Zebrafish

Acute Toxicity of Cu-MOF Nanoparticles (nanoHKUST-1) towards Embryos and Adult Zebrafish

An investigation of affecting factors on MOF characteristics for biomedical applications: A systematic review

The Toxicity of Secondary Lithium-Sulfur Batteries Components

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