&lt;p&gt;Transcranial magnetic stimulation for the treatment of anxiety disorder&lt;/p&gt;

Rodrigues, Priscila Aparecida; Zaninotto, Ana Luiza; Neville, Iuri Santana; Hayashi, Cintya Yukie; Brunoni, André R.; Teixeira, Manoel Jacobsen; Paiva, Wellingson Silva

doi:10.2147/ndt.s201407

Cited by 31 publications

(19 citation statements)

References 61 publications

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“…The active treatment groups of both techniques showed better results compared to the placebo group in relation to anxiety state (STAI-S) and maintaining this improvement in the medium-term (30-day follow-up). Although, anxiety associated with other neurological disorders 53 such as BPI associated with chronic pain 11 can negatively impact the quality of life, we do not obtained improvement in SF-36 scores. Indeed, the expected maintenance of physical disability throughout the course of treatment with NIBS techniques 43 probably contributed to not improving the quality of life.…”

Section: Interestingly Rtms Was Superior In Improving Multidimensional Aspects Of Pain (Mpq) Based On Previous Evidence With Mcs Multiplecontrasting

confidence: 70%

Effects of rTMS and tDCS on neuropathic pain after brachial plexus injury: A randomized placebo-controlled pilot study

Edb

Wkn

Carvalho

et al. 2021

Preprint

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Neuropathic pain (NP) after brachial plexus injury (NPBPI) is a highly disabling clinical condition and is increasingly prevalent due to increased motorcycle accidents. Currently, no randomized controlled trials have evaluated the effectiveness of non-invasive brain stimulation techniques such as Repetitive Transcranial Magnetic Stimulation (rTMS) and Transcranial Direct-Current Stimulation (tDCS) in patients suffering from NPBPI. In this study, we directly compare the efficacy of 10-Hz rTMS and anodal 2 mA tDCS techniques applied over the motor cortex (5 daily consecutive sessions) in 21 patients with NPBPI, allocated into 2 parallel groups (active or sham). The order of the sessions was randomised for each of these treatment groups according to a crossover design and separated by a 30-day interval. Scores for “continuous” and “paroxysmal” pain (primary outcome) were tabulated after the last stimulation day and 30 days after. Secondary outcomes included the improvement in multidimensional aspects of pain, anxiety state and quality of life. Active rTMS and tDCS were both superior to sham in reducing continuous (p < 0,001) and paroxysmal pain (p = 0.04) as well as in multidimensional aspects of pain and anxiety state. Repetitive TMS was superior to tDCS in reducing continuous (p = 0.01) and paroxysmal pain (p = 0.03), and in improving multidimensional aspects of pain (p = 0.01). Our results suggest rTMS and tDCS are able to treat NPBPI with little distinction in pain and anxiety state, which may promote the use of tDCS in brachial plexus injury pain management, as it constitutes an easier and more available technique.

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Section: Interestingly Rtms Was Superior In Improving Multidimensional Aspects Of Pain (Mpq) Based On Previous Evidence With Mcs Multiplecontrasting

confidence: 70%

Effects of rTMS and tDCS on neuropathic pain after brachial plexus injury: A randomized placebo-controlled pilot study

Edb

Wkn

Carvalho

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…1) and since 2018 for obsessivecompulsive disorder (Carmi et al 2019;Carmi et al 2018;Berlim et al 2013b). In addition, it has been shown to have potential benefits in multiple other conditions, including anxiety (Rodrigues et al 2019;Cirillo et al 2019), posttraumatic stress disorder (Kozel et al 2018;Watts et al 2012;Karsen et al 2014;Ahmadizadeh and Rezaei 2018), and fibromyalgia (Boyer et al 2014;Passard et al 2007;Mhalla et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Transcranial magnetic stimulation therapeutic applications on sleep and insomnia: a review

Oroz

Kung

Croarkin

et al. 2021

Sleep Science Practice

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Repetitive transcranial magnetic stimulation (rTMS) is a neuromodulatory technique approved by the US Food and Drug Administration for use in treatment-resistant major depressive disorder. It works by generating localized magnetic fields that create depolarizing electrical currents in neurons a few centimeters below the scalp. This localized effect is believed to stimulate neural plasticity, activate compensatory processes, and influence cortical excitability. Additionally, rTMS has been used in a variety of clinical trials for neurological and psychiatric conditions such as anxiety, post-traumatic stress disorder and epilepsy. Beneficial effects in sleep parameters have been documented in these trials, as well as in major depressive disorder, and have led to an interest in using rTMS in the field of sleep medicine for specific disorders such as insomnia, hypersomnia, and restless legs syndrome. It is unknown whether rTMS has intrinsically beneficial properties when applied to primary sleep disorders, or if it only acts on sleep through mood disorders. This narrative review sought to examine available literature regarding the application of rTMS for sleep disorder to identify knowledge gaps and inform future study design. The literature in this area remains scarce, with few randomized clinical trials on rTMS and insomnia. Available studies have found mixed results, with some studies reporting subjective sleep improvement while objective improvement is less consistent. Due to the heterogeneity of results and the variations in rTMS protocols, no definitive conclusions have been reached, signaling the need for further research.

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“…Some current evidence suggests that right-sided LF-rTMS or bilateral rTMS may be effective to improve both depressive and anxiety symptoms in MDD with comorbid anxiety disorders. According to a literature review, rTMS studies for treating anxiety disorders were few, and LF-rTMS (1 Hz) of the right DLPFC has been considered as a treatment option for the treatment of anxiety disorders [23]. Previous neurophysiological and imaging studies suggest that increased right DLPFC activity may be related to an increase in anxiety [24].…”

Section: Rtms Protocols For Mdd With Comorbid Anxiety Disordersmentioning

confidence: 99%

Personalization of Repetitive Transcranial Magnetic Stimulation for the Treatment of Major Depressive Disorder According to the Existing Psychiatric Comorbidity

Chou

Lin

et al. 2021

Clin Psychopharmacol Neurosci

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Repetitive transcranial magnetic stimulation (rTMS) and intermittent theta-burst stimulation (iTBS) are evidenced-based treatments for patients with major depressive disorder (MDD) who fail to respond to standard first-line therapies. However, although various TMS protocols have been proven to be clinically effective, the response rate varies across clinical applications due to the heterogeneity of real-world psychiatric comorbidities, such as generalized anxiety disorder, posttraumatic stress disorder, panic disorder, or substance use disorder, which are often observed in patients with MDD. Therefore, individualized treatment approaches are important to increase treatment response by assigning a given patient to the most optimal TMS treatment protocol based on his or her individual profile. This literature review summarizes different rTMS or TBS protocols that have been applied in researches investigating MDD patients with certain psychiatric comorbidities and discusses biomarkers that may be used to predict rTMS treatment response. Furthermore, we highlight the need for the validation of neuroimaging and electrophysiological biomarkers associated with rTMS treatment responses. Finally, we discuss on which directions future efforts should focus for developing the personalization of the treatment of depression with rTMS or iTBS.

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<p>Transcranial magnetic stimulation for the treatment of anxiety disorder</p>

Cited by 31 publications

References 61 publications

Effects of rTMS and tDCS on neuropathic pain after brachial plexus injury: A randomized placebo-controlled pilot study

Effects of rTMS and tDCS on neuropathic pain after brachial plexus injury: A randomized placebo-controlled pilot study

Transcranial magnetic stimulation therapeutic applications on sleep and insomnia: a review

Personalization of Repetitive Transcranial Magnetic Stimulation for the Treatment of Major Depressive Disorder According to the Existing Psychiatric Comorbidity

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