&lt;p&gt;Usefulness of Blood Parameters for Preliminary Diagnosis of Brucellosis&lt;/p&gt;

Akya, Alisha; Bozorgomid, Arezoo; Ghadiri, Keyghobad; Ahmadi, Mahnaz; Elahi, Azam; Mozafari, Hadi; Almasi, Afshin; Namadi, Parvin; Chegenelorestani, Roya

doi:10.2147/jbm.s245513

Cited by 18 publications

(13 citation statements)

References 36 publications

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“…Age, gender, Rose-Bengal test results, transaminase levels, and other laboratory parameters were not significantly different between the patients with and without complication(s) ( Table 2). The symptomatic periods were not different between the patients with and without complications [30(20-60) vs. 25 (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), p=0.07]. BAFF and APRIL levels were also indiscriminative between the patients, as shown in Table 2.…”

Section: Resultsmentioning

confidence: 92%

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Increased BAFF Levels in Children with Acute Brucellosis

Erdeniz¹,

Cevik²

2020

Trends in Pediatrics

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Objective: Brucellosis is a chronic infectious disease. We aimed to show the association of serum 'A PRoliferation-Inducing Ligand (APRIL) (TNFSF13A)' and 'B-cell Activating Factor (BAFF)' levels belonging to the tumor necrosis factor family in children with acute brucellosis. Methods: Fifty children with acute brucellosis and 35 healthy controls who were admitted during a two-year period between 2018 and 2020 were prospectively included in the study. All patients and healthy children were tested for complete blood counts, C-reactive protein, BAFF, and APRIL levels, and erythrocyte sedimentation rate. Results: The mean age of 50 patients with acute brucellosis was 10.2±3.6 years, and 37 (74%) of them was male. BAFF levels were significantly higher in children with acute brucellosis than the control group (548.6±253.4 vs. 280.5±83.6, p<0.001). In addition to APRIL levels, other laboratory tests were not statistically significantly different between the patients and control group. Neither BAFF and APRIL, nor age, gender, Rose-Bengal test results, transaminase levels, and other laboratory parameters were significantly different between the patients with and without any complication(s). ROC analysis showed that BAFF values above 330 pg/mL were 78% sensitive and 72% specific for the detection of acute brucellosis in children (area under curve:0.864, p<0.001, CI:0.787-0.941). Conclusion: BAFF levels were significantly elevated in children with acute brucellosis. BAFF levels above 330 pg/mL were 78% sensitive and 72% specific for the detection of the disease, but BAFF could not discriminate between patients with and without complications. APRIL, which has relatively similar effects, is not associated with acute pediatric brucellosis.

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Section: Resultsmentioning

confidence: 92%

“…Brucellosis can result in significant changes, such as increased AST, ALT, and GGT levels, (23) . Similarly, white blood cell, and neutrophil counts, and CRP levels can be significantly higher in the brucellosis patients (24) . The most common complication in brucellosis is osteoarticular pathologies (25) .…”

Section: Discussionmentioning

confidence: 96%

Increased BAFF Levels in Children with Acute Brucellosis

Erdeniz¹,

Cevik²

2020

Trends in Pediatrics

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“…13 , 14 The WBC count is often average or low, and lymphocyte count is increased in most patients; ESR is increased in the acute phase of the disease, yet is generally normal in the chronic phase. 15 , 16 Immunological tests such as RBPT and SAT have significant diagnostic value, SAT titer ≥1:160 is highly suggestive of Brucella infection. 13…”

Section: Discussionmentioning

confidence: 99%

Brucellar Knee Arthritis with Knee Joint Tuberculosis: A Case Report and Review of the Literature

Wang¹,

Li²,

Zhang³

2022

IDR

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Brucella and Mycobacterium tuberculosis (MTB) primarily affect the spine and only rarely the knee joint in osteoarticular disease in adults. We present an unusual instance of brucellar knee arthritis combined with knee joint tuberculosis. A 59-year-old man was initially diagnosed with brucellar knee arthritis in the orthopedics department of our hospital, while two weeks of standardized treatment did not improve the joint discomfort and inflammation indexes. Subsequent evaluation of serum tuberculosis interferon-gamma release assays (TB-IGRAs) and the effectiveness of empirical anti-tuberculosis therapy confirmed the mixed infection of tuberculosis. This case report demonstrates that clinical signs and imaging for brucellar knee arthritis and knee joint tuberculosis are similar. Patients with both disorders are more likely to be misdiagnosed or have their diagnosis delayed; clinicians should be aware of this uncommon combination of mixed infections.

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“…As a result of this study, they concluded that the most significant laboratory findings of brucellosis were increased number of WBC, while decreased numbers of thrombocytes and lymphocytes. 22 Pancytopenia and severe thrombocytopenia or isolated thrombocytopenia resulting in bleeding has rarely been reported in the course of brucellosis. 18,21,23 The pathogenesis of thrombocytopenia during brucellosis may be multifactorial such as; increased platelet clearance due to splenomegaly, the suppressive effect of brucellosis bacteremia on bone marrow, hemophagocytosis, and peripheral autoimmune destruction.…”

Section: Brusellosis In Pediatric Patients May Have a Wide Variety Of...mentioning

confidence: 99%

Clinicoepidemiological findings of childhood brucellosis in a tertiary care center in Central Anatolia: with the emphasis of hematological findings

Kaman¹,

Öz²,

Fettah³

et al. 2022

Turk J Pediatr

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Human brucellosis is one of the most widespread zoonotic diseases and a public health problem in many countries of the Mediterranean and Middle East where bovine brucellosis has not been controlled. It can affect people at any age including children. Approximately 20-30% of cases are diagnosed during childhood. [1][2][3] Humans can acquire infections via consumption of infected unpasteurized milk and milk products or direct contact with infected animals, secretions and carcasses. Brucellosis is a multisystemic disease which can be presented with various non-specific clinical signs. The most common clinical manifestations include arthralgia, fever, sweating, weight loss, fatigue, and anorexia. 1 Some of these

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<p>Usefulness of Blood Parameters for Preliminary Diagnosis of Brucellosis</p>

Cited by 18 publications

References 36 publications

Increased BAFF Levels in Children with Acute Brucellosis

Increased BAFF Levels in Children with Acute Brucellosis

Brucellar Knee Arthritis with Knee Joint Tuberculosis: A Case Report and Review of the Literature

Clinicoepidemiological findings of childhood brucellosis in a tertiary care center in Central Anatolia: with the emphasis of hematological findings

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