<p>Vertebroplasty in the treatment of osteoporotic vertebral compression fractures: patient selection and perspectives</p>

Abstract

Osteoporotic vertebral fractures represent a constantly increasing pathology that may compromise life quality and general health. Among various treatment options, percutaneous vertebroplasty has been used widely over the past 20 years. Although there is a vast amount of retrospective reports in the literature, high-level evidence has emerged only recently. In this paper, the authors provide a synopsis of the current literature on the efficacy and safety of percutaneous vertebroplasty while also presenting a step-by-step description of the surgical procedure, focusing on details that may help in optimizing quality and safety.

A Retrospective Study to Evaluate the Effect of Dynamic Fracture Mobility on Cement Leakage in Percutaneous Vertebroplasty and Percutaneous Kyphoplasty in 286 Patients with Osteoporotic Vertebral Compression Fractures

“…Optimal cement viscosity is subjective and multiple factors could influence it, such as storage conditions, mixed methods, operating room temperature, and surgeon experience [ 24 , 30 , 31 ]. To reduce the occurrence of bone cement leakage, the cement was injected during the phase of “toothpaste-like” consistency after mixing, according to most previous reports [ 32 ].…”

Safety and efficacy of Wharton's jelly-derived mesenchymal stem cells with teriparatide for osteoporotic vertebral fractures: A phase I/IIa study

“…According to previous randomized controlled trials, vertebral augmentation procedures (percutaneous vertebroplasty or balloon kyphoplasty) cause serious complications, including bone cement leakage, infection, and pulmonary embolism, 8,12 and are not superior to sham procedures for pain relief 8 . In addition, vertebral augmentation procedures do not affect bone metabolism and cannot prevent new fractures, but they can increase the risk of adjacent vertebral compression fractures 12 . Therefore, vertebral augmentation procedures may be applied to control back pain for those in whom conservative treatment fails or, accompanying immobilization, carries serious risks 12 …”

“…8 In addition, vertebral augmentation procedures do not affect bone metabolism and cannot prevent new fractures, but they can increase the risk of adjacent vertebral compression fractures. 12 Therefore, vertebral augmentation procedures may be applied to control back pain for those in whom conservative treatment fails or, accompanying immobilization, carries serious risks. 12 In terms of fracture healing after osteoporotic fractures, both MSCs and teriparatide (recombinant human parathyroid hormone…”

“…12 Therefore, vertebral augmentation procedures may be applied to control back pain for those in whom conservative treatment fails or, accompanying immobilization, carries serious risks. 12 In terms of fracture healing after osteoporotic fractures, both MSCs and teriparatide (recombinant human parathyroid hormone…”

“…8,9 Once nonunion advances to osteonecrosis and delayed vertebral collapse (Kummell's disease), the collapsed vertebrae causes a progressive kyphotic deformity and severe neural tissue compression with neurological deficits. 10,11 According to previous randomized controlled trials, vertebral augmentation procedures (percutaneous vertebroplasty or balloon kyphoplasty) cause serious complications, including bone cement leakage, infection, and pulmonary embolism, 8,12 and are not superior to sham procedures for pain relief. 8 In addition, vertebral augmentation procedures do not affect bone metabolism and cannot prevent new fractures, but they can increase the risk of adjacent vertebral compression fractures.…”