&lt;p&gt;Vessel Density in Glaucoma of Different Entities as Measured with Optical Coherence Tomography Angiography&lt;/p&gt;

Lommatzsch, Claudia; Rothaus, Kai; Jm, Koch; Heinz, Carsten; Grisanti, Salvatore

doi:10.2147/opth.s230192

Cited by 15 publications

(17 citation statements)

References 37 publications

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“…Previous studies have examined patients with XFG and POAG to assess the OCTA-based macular (7,11) and peripapillary (5,12-14) regions individually and together (9,(15)(16)(17)(18). Some of the results are consistent with our current research (11,12,14,17).…”

Section: Discussionsupporting

confidence: 90%

“…Some of the results are consistent with our current research (11,12,14,17). Several of these studies recorded observations once daily (11)(12)(13)(14)16,18), while a few used multiple observations, ranging from 2 to 5 per day. Considerable reduction in retinal VD in XFG eyes has been reported by some researchers (11)(12)(13), while others did not find a difference between the retinal VD assessments of XFG and POAG eyes (15).…”

Section: Discussionsupporting

confidence: 88%

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Magnitude of Diurnal Change in Retinal Vessel Density: Comparison Between Exfoliative Glaucoma and Primary Open-Angle Glaucoma

Demirtaş¹

2021

Beyoglu Eye J

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Objectives:The aim of this study was to investigate the magnitude of diurnal fluctuation in the superficial parafoveal vessel density (pfVD) and radial peripapillary capillary-peripapillary vessel density (RPC-ppVD) in exfoliative glaucoma (XFG) patients using optical coherence tomography angiography (OCTA) and to compare the findings with those of primary open-angle glaucoma (POAG) patients with glaucomatous damage of comparable severity. Methods: A total of 50 patients with XFG and 48 with POAG were examined in this retrospective cross-sectional study. The OCTA readings and intraocular pressure (IOP) values were obtained at 9 am, 11 am, 2 pm, and 4 pm on the same day. The maximal change in the IOP and vessel density (VD) values was evaluated to determine the magnitude of diurnal variation. Results: No significant difference was found in the magnitude of the average diurnal superficial-pfVD, RPC-ppVD and IOP change between the XFG and POAG groups. Comparison of the diurnal variation of sub-sector VD revealed that the magnitude of the diurnal variation in the VD of the inferonasal peripapillary and superior parafoveal regions was greater in the XFG group than that of the POAG group (p=0.004 and p=0.021, respectively). Furthermore, the differences persisted after correcting for the confounding factors of IOP, mean deviation (MD), and global retinal nerve fiber layer (RNFL) values. The magnitude of the average superficial-pfVD and the average RPC-ppVD was not correlated with the MD, total ganglion cell complex, global RNFL, or the magnitude of IOP values in either group. Conclusion:The eyes of XFG patients demonstrated more significant diurnal fluctuation in VD (including the superior superficial-pfVD as well as the inferonasal RPC-ppVD) when compared with POAG patients, despite no statistical significance between groups in the IOP variation.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 88%

Magnitude of Diurnal Change in Retinal Vessel Density: Comparison Between Exfoliative Glaucoma and Primary Open-Angle Glaucoma

Demirtaş¹

2021

Beyoglu Eye J

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“…Currently, it is hard to differentiate to what extent the vascular pathogenesis of PXG and POAG differs regarding the quantitative vascular deficit. While some studies show a tendency towards a macular vascular deficit in PXG compared to POAG eyes using OCTA [13,17], others do not [14,18].…”

Section: Discussionmentioning

confidence: 98%

“…While some studies show a tendency towards a macular vascular deficit in PXG compared to POAG eyes using OCTA [ 13 , 17 ], others do not [ 14 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, various questions about the blood flow situation in primary open-angle glaucoma (POAG) and pseudo-exfoliation glaucoma (PXG) have been investigated using different OCTA devices. Uniform results regarding differences in vascular parameters between POAG and PXG could not be ensured yet using the various devices (RTVue-XR SD-OCT, Cirrus HD-OCT, DRI OCT Triton; Topcon) [12][13][14][15][16][17][18][19]. So far, there has been a tendency for PXG to show a reduction in perfusion density,…”

Section: Introductionmentioning

confidence: 99%

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Macular, papillary and peripapillary perfusion densities measured with optical coherence tomography angiography in primary open angle glaucoma and pseudoexfoliation glaucoma

Cornelius

Pilger

Riechardt

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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Purpose To compare the blood flow situation in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG) using optical coherence tomography angiography (OCTA). Methods In this prospective study a total of 26 POAG and 23 PXG eyes were included. All patients underwent a complete ophthalmological examination including standard automated perimetry, stereoscopic photographs of the optic disc, peripapillary retinal nerve fibre layer analysis and examination of vascular parameters of the optic nerve head (ONH), the peripapillary region and macula using OCTA. In addition to the vascular parameters recorded by the device, the vascular images were graphically evaluated using Image J. All recorded vascular parameters were compared between both groups and correlated to structural and functional parameters. Results The mean superficial perifoveal plexus perfusion density (PD) was significantly lower in PXG eyes than compared to POAG eyes using OCTA (32.57% ± 3.57% vs. 34.92% ± 2.11%, p = 0.007). The mean PD parameters for the superficial peripapillary plexus (40.98% ± 3.04% vs. 42.09% ± 2.29%, p = 0.152) as well as the size of the foveal avascular zone (FAZ) (0.23 mm2 ± 0.1 mm2 vs. 0.23 mm2 ± 0.09 mm2) did not differ between both groups. Additional graphic evaluation using Image J showed no significant difference for superficial perifoveal plexus PD (32.97% ± 1.11% vs. 33.35% ± 0.95%, p = 0.194) and peripapillary plexus PD (46.65% ± 0.83% vs. 46.95% ± 0.5%, p = 0.127) between the groups. Retinal nerve fibre layer (RNFL) thickness correlated significantly with peripapillary plexus PD for both OCTA data and Image J data (p < 0.001, p = 0.032). Conclusion The severity of the glaucoma seems to be crucial for peripapillary and macular perfusion densities, and not the form of glaucoma. An additional graphic evaluation is a possible step that could be implemented to improve the comparability of OCTA scans and to optimize the possibility of quantitative perfusion analysis in the case of deviating quality criteria.

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Comparison between open-angle glaucoma and angle-closure glaucoma regarding the short-term optic disc vessel density changes after trabeculectomy

El-Haddad,

Abd Elwahab,

Shalaby

et al. 2023

Lasers Med Sci

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To compare the microvasculature of the optic disc in open-angle glaucoma (OAG) and angle-closure glaucoma (ACG) after trabeculectomy. This study included 34 patients divided into two groups based on the angle: (1) the OAG Group, which included 24 eyes from 24 patients, and (2) the ACG Group, which included ten eyes from 10 patients. All patients were subjected to comprehensive ophthalmic examinations. It included best-corrected visual acuity (BCVA), Goldmann applanation tonometry, gonioscopy, slit-lamp biomicroscopy, dilated fundus examination, and stereoscopic examination of the optic disc. The central corneal thickness was measured using a Nidek AL scan optical biometer. The visual field was evaluated by standard automated perimetry using Humphrey Field Analyzer (24–2 Swedish interactive threshold algorithm; Carl-Zeiss Meditec, Dublin, CA). Moreover, optical coherence tomography angiography (OCT-A) was performed utilizing the RTVue XR Avanti scanner (Optovue Inc., Fremont, CA, USA) preoperatively as well as 1 month after surgery. There was a statistically significant increase in optic disc vessel density (VD) in the whole image, radial peripapillary, inferior, superior, temporal, and nasal quadrant in OAG after surgery. Regarding the change in VD after surgery in ACG patients, there was a statistically significant increase in optic disc VD in the whole image, radial peripapillary, inferior, superior, temporal, and nasal quadrant in ACG after surgery.Regarding the percentage of VD change following trabeculectomy surgery, there were highly significant differences between the two groups for the whole image, radial peripapillary, inferior quadrant, and temporal quadrant VD. Statistically significant changes were also observed in the superior and nasal quadrants of VD. However, no significant change in VD was detected within the disc. In conclusion, the optic disc VD improved after the reduction of intraocular pressure (IOP) by surgery in both OAG and ACG. However, ACG demonstrated a significant improvement than the OAG.

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<p>Vessel Density in Glaucoma of Different Entities as Measured with Optical Coherence Tomography Angiography</p>

Cited by 15 publications

References 37 publications

Magnitude of Diurnal Change in Retinal Vessel Density: Comparison Between Exfoliative Glaucoma and Primary Open-Angle Glaucoma

Magnitude of Diurnal Change in Retinal Vessel Density: Comparison Between Exfoliative Glaucoma and Primary Open-Angle Glaucoma

Macular, papillary and peripapillary perfusion densities measured with optical coherence tomography angiography in primary open angle glaucoma and pseudoexfoliation glaucoma

Comparison between open-angle glaucoma and angle-closure glaucoma regarding the short-term optic disc vessel density changes after trabeculectomy

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