&lt;p&gt;Virchow&amp;rsquo;s node: a case report of an extremely rare presentation of metastasis of adenocarcinoma with mucinous features from the colon&lt;/p&gt;

Suliman, Mohamed; Singh, Monider; Ajmeri, Aman N; Stuart, David; Teka, Samson

doi:10.2147/ijgm.s201617

Cited by 13 publications

(14 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other sites include lung, peritoneum, ovary, central nervous system, bone, kidney and uterus. Adrenal gland, hilar lymph node, skin and muscle are the extremely rare metastatic sites for colorectal cancer [7].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cervical lymph node enlargement as the initial manifestation of rectal cancer

Xie

Hong

et al. 2021

BMC Gastroenterol

View full text Add to dashboard Cite

Background Colorectal cancer is a very common malignant tumor worldwide. The clinical manifestations of advanced colorectal cancer include the changes in bowel habits, hematochezia, diarrhea, local abdominal pain and other symptoms. However, the colorectal cancer with an initial symptom of cervical lymph node enlargement is extremely rare. In this article, we report a case of rectal cancer presenting with cervical lymph nodes enlargement as the initial symptom. Case presentation A 57-year-old woman was admitted to our hospital for cervical lymph node enlargement which was accidentally detected during physical examination. Computed tomography scan revealed multiple enlarged lymph nodes in the neck. Cervical ultrasound showed normal thyroid gland and multiple left supraclavicular lymph nodes enlargement. The patient underwent lymph nodes biopsy and pathologic results showed metastatic adenocarcinoma. The subsequent lower gastrointestinal endoscopy revealed a mucosal bulge lesion located at rectus and biopsy revealed adenocarcinoma. The patient underwent rectal cancer resection. She is alive with no evidence of recurrence or new tumors 2 years after surgery. Conclusions Cervical lymph node metastasis is a rare metastatic way in colorectal cancer. This is the first case of rectal cancer presenting with cervical lymph nodes metastases as the initial symptom. Surgical resection combined with postoperative chemotherapy improved long-term prognosis of the patient. This rare metastatic way of rectal cancer should be paid attention for clinicians.

show abstract

Section: Discussionmentioning

confidence: 99%

“…At present, the mechanism of distant non-regional lymph nodes metastases in patients with colorectal cancer remains unclear. According to previous reports [7], skip micrometastasis between regional lymph nodes can • thorough peer review by experienced researchers in your field…”

Section: Discussionmentioning

confidence: 99%

Cervical lymph node enlargement as the initial manifestation of rectal cancer

Xie

Hong

et al. 2021

BMC Gastroenterol

View full text Add to dashboard Cite

show abstract

“…Multivariate Cox regression shows that M stage is an independent prognostic factor of the three survival styles. Typically, the most common sites of rectal cancer metastasis are regional lymph nodes, liver, lung, bone and brain [47]. Haematogenous metastasis is very common in rectal cancer metastasis.…”

Section: Discussionmentioning

confidence: 99%

A nomogram to predict the prognosis of patients with unresected rectal adenocarcinoma undergoing chemoradiotherapy: a population-based study

Liu¹,

Sun²,

Xiang³

2021

J. Cancer

View full text Add to dashboard Cite

Background: Chemotherapy combined with radiotherapy is the main treatment strategy for unresectable rectal cancer. However, the prognostic factors of patients with unresectable rectal cancer treated with radiotherapy and chemotherapy have not been systematically studied. Therefore, this study investigated the prognostic factors and prognosis based on surveillance, epidemiology and final results of the SEER medical insurance database. Methods: Primary rectum patients were selected from the SEER database. The independent prognostic factors associated with overall survival (OS), cancer-specific survival (CSS) and noncancer-related death were evaluated using the Kaplan-Meier method and log-rank test, a competing risk model, and the Cox proportional hazards regression model. Two nomograms were established for predicting the 1-and 3-year OS and CSS of patients.Results: A total of 3,998 rectal adenocarcinoma cancer patients who received chemoradiotherapy but had not undergone surgery were included in this study and divided into training (n = 3559) and validation cohorts (n = 439). Patients in the training cohort had a 1-year OS rate of 65.7±0.8%, a 3-year OS rate of 26.6±0.8%, a 5-year OS rate of 1.6±0.8%, and a median survival rate of 20.0 months (range, 19.22-20.8 months). The following factors were significant prognostic factors of OS: age (p< 0.001); tumour grade (p< 0.001); T stage (p< 0.001); M stage (p< 0.001); bone metastasis (p<0.001); brain metastases (p<0.001); liver metastases (p<0.001); lung metastases (p<0.001); marital status (p<0.001) and insurance status (p=0.005). Age (p< 0.001), tumour grade (p< 0.001), T stage (p< 0.001), M stage (p< 0.001), bone metastasis (p<0.001), brain metastases (p<0.001), liver metastases (p<0.001), lung metastases (p<0.001) and race (p=0.034) were independent prognostic factors of CSS. Age (p< 0.001), T stage (p< 0.001), N stage (p=0.007), M stage (p<0.001), liver metastases (p<0.001), lung metastases (p<0.001), marital status (p<0.001) and insurance status (p=0.019) were independently associated with noncancer-related death. Conclusion: Age, tumour grade, T and M stage, bone, brain, liver and lung metastases, marital status and insurance status are independent risk factors for the OS of rectal adenocarcinoma patients who have undergone chemoradiotherapy but have not undergone surgery. Age, tumour grade, T stage, M stage, bone, brain, liver, lung metastases and race were independent prognostic factors of CSS. Age, T, N and M stage, liver and lung metastases, marital status and insurance status, were independently associated with noncancer-related death. Interestingly, the earlier the T stage was, the higher the rate of noncancer-related death. Two nomograms were developed to predict OS and CSS, and the C-indexes were 0.6776 and 0.6744, respectively. Rectal cancer screening is strongly recommended for patients under the age of 50.

show abstract

“…CRC with distant lymph node metastasis is very rare. Although a few cases[ 3 - 6 ] of synchronous supraclavicular lymph node metastases from colorectal carcinoma have been reported (Table 1 ), most were complicated with multiple metastases or treated exclusively with chemotherapy. To the best of our knowledge, this is the first case of lymph node dissection combined with chemotherapy to treat isolated synchronous Virchow’s lymph node metastasis from sigmoid cancer (Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

Isolated synchronous Virchow lymph node metastasis of sigmoid cancer: A case report

Yang¹,

Liu²,

Li³

et al. 2021

WJCC

View full text Add to dashboard Cite

BACKGROUND Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract. Lymphatic metastases of this tumor are mostly confined to the regional lymph nodes, and distant supraclavicular lymph node metastases are very rare. CASE SUMMARY In this report, we describe a patient with sigmoid carcinoma and isolated synchronous supraclavicular lymph node metastases. A 56-year-old male presented with a left cervical mass that was confirmed as a lymph node metastasis from sigmoid cancer by several auxiliary examinations. After 6 cycles of chemotherapy with the 5-fluorouracil, leucovorin and oxaliplatin + cetuximab regimen, the sigmoid colon tumor and Virchow’s lymph node metastasis were significantly smaller than before treatment, and no new metastatic sites were observed. Considering the effects of chemotherapy on quality of life, resection of the primary tumor was performed followed by 4 cycles of chemotherapy with the original chemotherapy regimen. Virchow’s lymph node dissection was selected by mutual consultation between the patient and us. After the second surgery, the patient received capecitabine and cetuximab chemotherapy and did not experience recurrence or metastasis during follow-up. CONCLUSION In conclusion, supraclavicular lymph node metastasis without any other solid organ metastasis is a potential metastatic pathway for CRC. In addition, after resection of the primary lesion, postoperative chemotherapy combined with supraclavicular lymph node dissection is feasible for the treatment of patients with CRC and isolated synchronous Virchow’s lymph node metastases.

show abstract

<p>Virchow’s node: a case report of an extremely rare presentation of metastasis of adenocarcinoma with mucinous features from the colon</p>

Cited by 13 publications

References 10 publications

Cervical lymph node enlargement as the initial manifestation of rectal cancer

Cervical lymph node enlargement as the initial manifestation of rectal cancer

A nomogram to predict the prognosis of patients with unresected rectal adenocarcinoma undergoing chemoradiotherapy: a population-based study

Isolated synchronous Virchow lymph node metastasis of sigmoid cancer: A case report

Contact Info

Product

Resources

About