<p>VYC-12 Injectable Gel Is Safe And Effective For Improvement Of Facial Skin Topography: A Prospective Study</p>

Abstract

ObjectiveEvaluate safety and effectiveness of VYC-12 (Juvéderm Volite; an injectable crosslinked hyaluronic acid gel designed to improve skin quality attributes such as surface smoothness and hydration) for facial intradermal injection.Materials and methodsIn a prospective, single-arm study, subjects with moderate/severe cheek skin roughness per Allergan Skin Roughness Scale (ASRS) received VYC-12 in the cheeks and forehead, and/or neck, with touch-up treatment to correct asymmetry 30 days later and optional repeat treatment 9 months after last treatment. The primary effectiveness measure was ASRS responder rate (percentage of cheeks with ≥1-point improvement from baseline) at month 1. Skin hydration was instrument-assessed.ResultsOf 131 subjects treated, 31 (23.7%) received touch-up treatment. ASRS responder rate was 96.2% at month 1, 76.3% at month 4, 34.9% at month 6, and 87.1% after repeat treatment. Responder rate in cheeks with severe baseline roughness was 93.8%, 83.1%, and 52.3% at months 1, 4, and 6, respectively. Skin hydration improved significantly (P<0.01) from baseline at all timepoints through month 9. Injection site responses were as expected. All treatment-related adverse events were mild/moderate.ConclusionVYC-12 safely and effectively improved skin smoothness up to 6 months and hydration lasting 9 months.

The interaction between hyaluronidase and hyaluronic acid gel fillers - a review of the literature and comparative analysis

“…Even denser crosslinking is present in Juvéderm Volbella XC (15 mg/mL), which is manufactured with a higher proportion of low molecular weight HA and designed for lip augmentation and perioral rhytids [29] . Juvéderm Volite, the least concentrated variety at 12 mg/mL, is for superficial cutaneous depressions and fine lines [30] .…”

HA Filler Injection and Skin Quality–Literature Minireview and Injection Techniques

“…Other studies have found evidence of objective skin quality improvement after using a new cross-linked injectable product (VYC-12 HA; Juvéderm Volite, Allergan) via digital photographic analysis. 11,12 This quality improvement effect can last up to 6 months, and the hydration retention effect can last for as long as 9 months after a single injection treatment.…”

“…Various injectable filler material, such as poly-L-lactic acid (PLLA), hyaluronic acid (HA), and hydroxylapatite, have shown the ability to induce new collagen formation after injection, thereby improving skin thickness or skin quality. 7 8 9 10 11 12 13 In this short review, the author will examine the current evidence and possibilities for treatment, and draw from personal experience to formulate expert recommendations, focusing on HA filler injections in particular.…”

Hyaluronan Hydrogels for Injection in Superficial Dermal Layers: An In Vitro Characterization to Compare Performance and Unravel the Scientific Basis of Their Indication

“…Unlike typical "volumetric" fillers, skinboosters are intended for the injection into more superficial (intradermal vs. deep dermis-periosteum) skin layers and are expected to improve skin appearance and texture rather than performing by a projection effect. Specifically, improvement in skin hydration and elasticity, and possibly a boost in extracellular matrix molecules biosynthesis is claimed after the application of such gels [28][29][30][31][32][33]. A stretching effect, referring to wrinkle distension from gel hydration, that is anyway filling the volume loss to a certain extent, is also predicted [30].…”