<span>Information Signatures of Viral Proteins: </span> <span>A Study of Influenza A Hemagglutinin and Neuraminidase</span>

Abstract

Hemagglutinin (HA) and neuraminidase (NA) are glycoproteins encoded by several types of viral particles. Most notably, they exercise complementary chemical functions during infection and propagation of influenza A. This research focuses on the primary structure information of the proteins, applying a computational model from previous research. Data for multiple influenza A subtypes are illustrated via information signatures and phase plots. These illuminate new ways of evaluating molecules for their virulence potential. The results further point to mutation strategies for attenuating the functions.