<strong>Complementary Application of the Ozonized Saline Solution in Moderate and Severe Patients with Pneumonia Covid-19: Efficacy and Tolerability</strong>

Abstract

Currently, there is no effective antiviral therapy recommended for the new coronavirus disease 2019 pneumonia (COVID-19). The purpose of this study was to evaluate the safety and efficacy of Ozonized Saline Solution (O3SS) used as a complementary therapy in adult patients with mild to severe COVID-19. Twenty-five adult patients who were hospitalized with mild to severe COVID-19 symptoms, who met the inclusion criteria and were being treated from April 3rd to April 26th, 2020, at the Viamed Virgen De La Paloma Hospital, Madrid, Spain were included in this study. Patients were allocated to receive standard care (SC) that included 200-400 mg hydroxychloroquine twice daily for 5-7 days plus Tocilizumab 400 mg twice daily for 5 days, low molecular weight heparin (LMWH) and 40 mg-60 mg metil-prednisone plus O3SS, 200 mL, 3-5 &amp;micro;g/mL daily for 10 days. Primary outcomes of treatment with O3SS were an improvement of clinical symptoms and a reduction in mortality. Secondary end points evaluated included participant clinical status, laboratory examinations, and duration of viral shedding. None of the patients treated with SC + O3SS died. Improvements in symptoms such as dyspnea, weakness, and reduction in body temperature were observed and corresponded with an improvement of laboratory finding including D-dimer, fibrinogen, LDH, and CRP. No side effects from the O3SS treatment were observed. Conclusions: COVID-19 patients with mild to severe symptoms who received intravenous O3SS as a complementary therapy demonstrated improved clinical symptoms, improved laboratory values and a reduction in mortality.

Compassionate use of rectal Ozone (O3) in severe COVID-19 pneumonia: a case-control study.

“…In the present study, bilateral radiographic pneumonia improved from 4.78 to 3 (on Taylor's radiologic Scale) in Ozone-group (p=0.0000); while in the Standard-of-care Group, improvement was just moderate (from 4.25 to 3.75) according to Taylor's Scale (p=0.3145).There is a clear improvement in bilateral pneumonia in favor of Ozone treatment, as evidenced by improvement in Taylor's radiologic Scale. Our ndings correlate with Schwartz' study, in which radiologic signs of pneumonia changed from 60% lung affection to 24% lung affection; and the improvement was observed at 3-5 days of Ozone treatment 23 . The great improvement on Taylor radiological Scale observed in Ozone-Group would explain why Ozone patients improved in O 2 -saturation and decreased in O 2 -supply.…”

“…Schwartz et al have stated that Ozonized saline solution was capable of decreasing in ammation Biomarkers from baseline (Ferritin 561 ng/mL, LDH 423 U/L, D-Dimer 905 ng/mL, CRP 33.7 mg/mL) to the end of treatment. In fact, by the10 th day of treatment, Fibrinogen and LDH were on normal ranges in all COVID-19 patients 23 . Hernandez et al have stated that Ozone autohemotherapy decreased in ammatory biomarkers (Ferritin, LDH, D-Dimer and CRP) signi cantly at 7 days after treatment started 24 .…”

“…It is expected that older patients show worst clinical outcomes, but Ozone was effective even in older COVID-19 patients 11 . As far as we know, our study has treated the oldest patients, if compared with other ozone studies [21][22][23][24] . 21 .…”

“…Schwartz has reported no mortality on the Ozone-Group, but a 20.7-21.1% mortality rate in homogeneous groups treated by Standard-of-care 23 . All previous studies stated a lower mortality for the Ozone-group than in the Standard-of-care Group.…”

“…In Araimo's study (Ozone autohemotherapy vs Standard-of-care for COVID-19 management in RCT design) it was observed that Ozone-group moderately reduced the need for ventilatory support (reduced use of CPAP [continuous positive air pressure], high ow nasal cannula or venturi mask) 5 . In Schwartz' study (Ozonized Saline Solution in a prospective before-after study in COVID- 19), patients that required supplemental O 2 decreased from 68% to 24% 23 . From the cited articles, it could be inferred that Ozone (by rectal, autohemotherapy or by ozonized saline solution application) is capable of improving ventilatory Indexes, mainly O 2 -saturation and O 2-supply, as it was observed in our study.…”