&lt;strong&gt;Knowing the Mechanisms: How Probiotics Affect the Development and Progression of Cancer&lt;/strong&gt;

Patil, Abhinandan; Kotekar, Devika; Chavan, Ghanshyam

doi:10.20944/preprints202307.0243.v1

Cited by 6 publications

(3 citation statements)

References 30 publications

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“…Probiotics can also bring back microbial variety and improve barrier function, which makes it less likely that pathogens will take up residence and cause an infection. Clinical studies have shown that certain strains of probiotics are effective at preventing and treating a number of infectious illnesses, such as stomach and lung infections [32][33][34][35][36][37].…”

Section: Probioticsmentioning

confidence: 99%

Microbiota Modulation: Examining the Effects on Pathogen Colonization and Infection

Patil¹,

Singh²

2023

Preprint

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The trillions of bacteria that live in and on our bodies make up the human microbiota, which is a very important part of keeping us healthy and protecting us from pathogenic infections. Dysbiosis is when there are changes in the composition and variety of the microbiota. This can upset the delicate balance between the host and its microbes, making the host more vulnerable to pathogens. Understanding the complicated link between microbiota and pathogens is important for coming up with effective ways to change microbiota and boost the body's defenses against infections. This study looks at how microbiota modulation affects the spread of pathogens and infections. It talks about how the makeup of microbiota affects how susceptible you are to pathogens. It shows how a healthy microbiota can protect you by making it hard for pathogens to grow and take over. The review also goes into detail about how the microbiota protects against pathogens, such as through competitive exclusion, the production of antimicrobial compounds, and the regulation of immune reactions. The study also looks at the idea of dysbiosis and how it is linked to pathogenic shifts. Disruptions in the microbiota can make it easier for pathogens to grow and make it harder for the host to fight off infections. It focuses on the need to recover microbial balance to improve the host's defenses and lower risks caused by pathogens. There is also talk about the use of probiotics, prebiotics, and fecal microbiota transplantation (FMT) as ways to change the microbiome. The goal of these interventions is to restore the diversity and function of microbes, improve the integrity of barriers, and boost the immune system's reaction to pathogens. The review shows how these methods could be used to change the microbiota and make it easier for the body to fight off infections. In conclusion, knowing how the microbiota and pathogens work together in a complicated way can help a lot when it comes to making specific interventions for microbiota modulation. Strategies that restore the balance of microbes and boost the host's defenses could stop pathogens from taking over and making people sick. More study needs to be done in this area to improve therapeutic approaches and use the microbiota to its fullest extent to fight infectious diseases.

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Section: Probioticsmentioning

confidence: 99%

Microbiota Modulation: Examining the Effects on Pathogen Colonization and Infection

Patil¹,

Singh²

2023

Preprint

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“…Risk-benefit analyses of medical interventions, including probiotics for the treatment of gastrointestinal problems, are essential. The purpose of this essay is to shed light on the need to weigh the risks and benefits of using probiotics for the treatment of gastrointestinal disorders [26,[27][28][29][30][31][32][33][34].…”

Section: The Risk-benefit Analysis Of Probiotics For the Treatment Of...mentioning

confidence: 99%

Probiotics in the Treatment of Gastrointestinal Disorders and What We Know About Their Effect on Microbiota

Patil,

Singh

2023

Preprint

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Modulating the gut microbiota with probiotics has been identified as a promising therapeutic method for the management of gastrointestinal illnesses. The effectiveness of probiotics in the treatment of gastrointestinal disorders can only be determined by delving into their underlying mechanisms of action. Through an analysis of the underlying processes, this study hopes to provide light on the potential benefits of probiotics for treating a variety of gastrointestinal conditions. The study covers a wide variety of gastrointestinal conditions, such as IBS, IBD, and antibiotic-associated diarrhea. Modifying the gut microbiota composition, strengthening the gut barrier function, modulating the immune system, and producing beneficial metabolites are among mechanisms of action that have been investigated. The strain- and dose-specific variables essential to getting the best treatment results are also highlighted. This review, which synthesizes the current information, gives a thorough overview of the effectiveness of probiotics in treating a variety of gastrointestinal illnesses and illuminates potential avenues for further study and therapeutic use.

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“…Biomarkers could help predict which patients are most likely to benefit from probiotic therapy and track how well treatments are working. Molecular markers in the gut bacteria, the immune system of the host, and the microenvironment of the tumor could be good predictors of how well a treatment is working and help choose probiotics for specific interventions [28][29][30][31][32][33][34][35][36][37].…”

Section: Goals For the Futurementioning

confidence: 99%

Probiotics in Cancer Treatment: From the Laboratory to Clinical Practice

Patil¹

2023

Preprint

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Probiotics are now being looked at as a possible addition to cancer treatments in both study and clinical settings. This study tries to give an overview of probiotic research as it relates to cancer, with a focus on how it might help avoid cancer, treat it, and improve the health of cancer patients. We look at developmental studies that use cell culture and animal models to look at how well probiotics work in cancer. We focus on how probiotics change the immune system, inflammation, and gut bacteria. The results of clinical studies that looked at probiotics as an add-on therapy for cancer patients are looked at to see how they affected the treatment success, side effects, and quality of life of the patients. We look at the possible benefits of probiotics for certain types of cancer, such as colorectal cancer, breast cancer, and stomach tumors. We also find the best probiotic strains for each type of cancer. We also look at the synergistic benefits of combining probiotics with standard cancer treatments like chemotherapy, radiation therapy, and immunotherapy to improve the effectiveness of treatment and lower side effects. Lastly, we talk about the present problems and future directions of probiotic research for cancer. We focus on personalized methods, ideal doses and treatment plans, finding signs of treatment success, and making probiotic-based therapies. By learning more about how probiotics could be used to treat cancer, we can create personalized, successful, and well-tolerated probiotic treatments to improve cancer outcomes.

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<strong>Knowing the Mechanisms: How Probiotics Affect the Development and Progression of Cancer</strong>

Cited by 6 publications

References 30 publications

Microbiota Modulation: Examining the Effects on Pathogen Colonization and Infection

Microbiota Modulation: Examining the Effects on Pathogen Colonization and Infection

Probiotics in the Treatment of Gastrointestinal Disorders and What We Know About Their Effect on Microbiota

Probiotics in Cancer Treatment: From the Laboratory to Clinical Practice

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