<strong>Synthesis of &alpha;-aminophosphonates and related derivatives under microwave conditions</strong>

Abstract

α-Aminophosphonates and related derivatives represent one of the most important class of organophosphorus compounds. The most widely applied synthetic routes towards α-aminophosphonates involve the Kabachnik-Fields condensation and the Pudovik reaction. In this paper the microwave (MW)-assisted catalyst-and mostly solvent-free syntheses of various α-aminophosphonates and α-aminophosphine oxides are discussed. Bis(aminophosphonate) derivatives were also prepared by the double Kabachnik-Fields reaction. Furthermore, the synthesis of amino-methylenebisphosphonates and amino-methylenebisphosphine oxides is also described.