<strong>Synthesis of Novel Ylides via a cascade Process: Ugi 4CR/Ylide Initiated Michael/ Chromone Ring Opening</strong>

Abstract

The development of efficient methods for the synthesis of heterocyclic compounds is always of great importance for chemists. In this perspective, we describe a general approach for the synthesis of functionalized heterocyclic compounds via Ugi MCR with 3-formyl chromone, amine, 2-chloro acetic acid and isocyanide followed by intramolecular ylide initiated Michael reaction, In this case, the reaction proceeds via in-situ generated phosphonium salt that give scope in formation of novel stable heterocyclic ylides. We especially emphasize the importance of tuning the Ugi adduct for the points of molecular diversity by designing intramolecular ylide initiated Michael reaction with chromone based moiety as Michael acceptor, 2-chloro acetic acid in Ugi reaction that helps for in situ generation of phosphonium salt that allows formation of a different class of heterocyclic compounds.