&lt;sup&gt;31&lt;/sup&gt;P Magnetic Resonance Spectroscopy Study of Cerebral Metabolism in Developing Dog Brain and Its Relationship to Neuronal Function

Nioka, Shoko; Zaman, Aziza; Yoshioka, Hiroshi; Masumura, Makoto; Miyake, Hidekazu; Lockard, S; Chance, Britton

doi:10.1159/000112142

Cited by 9 publications

(2 citation statements)

References 15 publications

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“…Trans forming growth factor is known to modulate the inflam matory response and have growth inhibitory activity in vitro for most epithelial cell types [31,32]. Rapid brain development occurs in dogs up to 2 -3 months of age [33]. Because of congenitally absent mucociliary clear ance, dogs with CCD frequently develop bronchopneu monia during the first 2 months of age and Mycoplasma sp.…”

Section: Discussionmentioning

confidence: 99%

Communicating Hydrocephalus in Dogs with Congenital Ciliary Dysfunction

Daniel¹,

Edwards²,

Harvey³

et al. 1995

Dev Neurosci

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Magnetic resonance imaging (MRI) and radionuclide ventriculography were performed in 5 dogs with congenital ciliary dysfunction (CCD) and 3 normal dogs. Ventricular and brain dimensions and volumes, and CSF flow rates were measured or calculated from the MR images and radionuclide clearance. All CCD dogs had hydrocephalus based on previously published criteria of a percent vertical brain dimension (PVBD) greater than 14%. The PVBD was significantly larger (p = 0.001) in the dogs with CCD (mean ± SD) 33.00 ± 5.42% than in normal dogs 11.07 + 0.61 %. The ventricular volume was significantly larger (p = 0.021) in CCD dogs 10,841 ± 4,127 mm³ compared to the volume measured in normal dogs 3,069 ± 1,167 mm³. The CSF flow rate was not significantly different (p = 0.876) between CCD dogs (253.00 ± 147.25 mm³/h) and normal dogs (267.667 ± 47.61 ram³/h). This suggests that the ventricular dilation in CCD dogs is not due to impedance of CSF flow from the ventricular system by dysfunctional ependymal cilia.

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Section: Discussionmentioning

confidence: 99%

Communicating Hydrocephalus in Dogs with Congenital Ciliary Dysfunction

Daniel¹,

Edwards²,

Harvey³

et al. 1995

Dev Neurosci

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“…These 31 P NMR spectra from rodent, cat, dog, or human brain – depicted resonances from adenosine triphosphate (ATP), phosphocreatine (PCr), inorganic phosphate (Pi), phosphomonoesters (PME, mainly phosphorylethanolamine), and phosphodiesters (PDE, glycerophosphorylcholine; Hilberman etal., 1984; Komatsumoto etal., 1987; Nioka etal., 1991). With this technique it was possible to follow non-invasively the rates of PCr breakdown and recovery after hypoxic and ischemic episodes.…”

Section: Introductionmentioning

confidence: 99%

13C NMR spectroscopy applications to brain energy metabolism

Rodrigues

Valette

Bouzier‐Sore

2013

Front. Neuroenergetics

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13C nuclear magnetic resonance (NMR) spectroscopy is the method of choice for studying brain metabolism. Indeed, the most convincing data obtained to decipher metabolic exchanges between neurons and astrocytes have been obtained using this technique, thus illustrating its power. It may be difficult for non-specialists, however, to grasp thefull implication of data presented in articles written by spectroscopists. The aim of the review is, therefore, to provide a fundamental understanding of this topic to facilitate the non-specialists in their reading of this literature. In the first part of this review, we present the metabolic fate of 13C-labeled substrates in the brain in a detailed way, including an overview of some general neurochemical principles. We also address and compare the various spectroscopic strategies that can be used to study brain metabolism. Then, we provide an overview of the 13C NMR experiments performed to analyze both intracellular and intercellular metabolic fluxes. More particularly, the role of lactate as a potential energy substrate for neurons is discussed in the light of 13C NMR data. Finally, new perspectives and applications offered by 13C hyperpolarization are described.

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Dynamic study of cerebral bioenergetics and brain function using in vivo multinuclear MRS approaches

Chen

Zhu

2005

Concepts Magn. Reson.

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ABSTRACT:One of the greatest merits of nuclear magnetic resonance (NMR) methodology used in biomedical research and clinical settings is its capability of measuring various physiological parameters in vivo. Besides MR imaging (MRI), which has been routinely applied to obtain vital information in living organs at normal and diseased states, in vivo MR spectroscopy (MRS) provides an invaluable tool for determining metabolites, chemical reaction rates, bioenergetics, and their dynamic changes in the human and animals noninvasively. These MRS capabilities are further enhanced at high/ultrahigh magnetic fields because of significant gain in NMR detection sensitivity and improvement in the spectral resolution. Recent progress has shown that in vivo MRS holds great promise in many biomedical research areas-in particular, brain research. This article provides a broad review of (i) in vivo multinuclear MRS approaches, (ii) advanced MRS methodologies, and (iii) MRS applications for determining cerebral metabolism as well as bioenergetics at resting brain state and their dynamic changes in response to brain activation.

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<sup>31</sup>P Magnetic Resonance Spectroscopy Study of Cerebral Metabolism in Developing Dog Brain and Its Relationship to Neuronal Function

Cited by 9 publications

References 15 publications

Communicating Hydrocephalus in Dogs with Congenital Ciliary Dysfunction

Communicating Hydrocephalus in Dogs with Congenital Ciliary Dysfunction

13C NMR spectroscopy applications to brain energy metabolism

Dynamic study of cerebral bioenergetics and brain function using in vivo multinuclear MRS approaches

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