&lt;title&gt;Aluminium hydroxide tetra-3-phenylthiophthalocyanine as new photosensitizer for photodynamic therapy and fluorescent diagnostics&lt;/title&gt;

Меерович, И. Г.; Смирнова, З. С.; Оборотова, Н. А.; Luk’yanets, E. A.; Меерович, Г. А.; Derkacheva, V. M.; Полозкова, А. П.; Kubasova, I. Yu.; Baryshnikov, A. Yu.

doi:10.1117/12.640120

Cited by 2 publications

(3 citation statements)

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“…According to our estimates, the high efficiency of the therapeutic irradiation is achieved if the absorbance of the photosensitizer exceeds the intrinsic absorption of biological tissue about three times [1]. At a high intrinsic absorption of biological tissue energy efficiency of the therapeutic radiation is significantly reduced.…”

Section: Doi: 101134/s1070363215010430mentioning

confidence: 95%

“…The use of such photosensitizers allows to minimize losses to its own tissue uptake, increase the depth of penetration of the excitation light and with the optimal choice of their concentration in tissues to provide a preferential effect on the pathological site. Studies [1,2] show that the efficacy of photodynamic therapy with irradiation of deep tumors increases with the photosensitizer dose only up to a certain limit, and then it is reduced because of the shielding of deep layers by sensitized subsurface layers.…”

Section: Doi: 101134/s1070363215010430mentioning

confidence: 99%

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Near-infrared photosensitizers based on nanostructured forms of phthalocyanine derivatives

et al. 2015

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The research is devoted to development and study of photosensitizers on a base of injectable nanoparticular formulations of phthalocyanine derivatives absorbing at long wavelength (near-infrared) range of 710-740 nm: Thiosens [liposomal form of aluminum hydroxide 1,8,15,22-tetrakis(phenylsulfanyl)phthalocyanine] and Octasens [polymeric micellar form of zinc 1 ,4,8,11,15,18,22,25-octachloro-2,3,9,10,16,17,23,24-octakis-(decylsulfanyl)phthalocyanine based on domestic poloxamer . Experiments have shown that the photosensitizers under study show high selectivity of accumulation and prolonged retaining at high concentration in tumor, relatively fast clearance from normal tissue and high therapeutic efficiency of photodynamic treatment on model tumors.

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Section: Doi: 101134/s1070363215010430mentioning

confidence: 95%

Section: Doi: 101134/s1070363215010430mentioning

confidence: 99%

Near-infrared photosensitizers based on nanostructured forms of phthalocyanine derivatives

et al. 2015

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“…Photosensitizer was administered via the tail vein at dose of 4 mg/kg. Level and selectivity of accumulation of Tiosens in tumor were studied by in vivo fluorescent spectroscopy method [8] using fiberoptic spectroanalyzer LESA-01-Biospec (Biospec, Russia).…”

Section: Methodsmentioning

confidence: 99%

Influence of vesicle size distribution on level and selectivity of accumulation of liposomal photosensitizer Tiosens in tumor

Меерович

Gurevich

et al. 2007

SPIE Proceedings

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The work was performed to estimate the influence of liposomal size distribution on the level and selectivity of accumulation of photosensitizer of near-IR spectral range Tiosens (liposomal form of aluminium hydroxide phenylthiophthalocyanine) in tumor. Tiosens liposome dispersions were prepared using classic Bangham procedure. Particle size was reduced and unified using Avanti Mini-Extruder equipped with Nucleopore membranes and highpressure homogenizer Donor-1. Liposomal size distribution was determined by means of laser correlation spectroscopy. Dynamics and selectivity of Tiosens accumulation in Erlich tumor were measured in vivo using fluorescence spectroscopy. It was shown that level and selectivity of accumulation of liposome-encapsulated drug is determined mostly by content of small-sized fractions, while fractions of larger size are quickly cleared from blood by RES and not contribute in photosensitizer accumulation.

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<title>Aluminium hydroxide tetra-3-phenylthiophthalocyanine as new photosensitizer for photodynamic therapy and fluorescent diagnostics</title>

Cited by 2 publications

References 8 publications

Near-infrared photosensitizers based on nanostructured forms of phthalocyanine derivatives

Near-infrared photosensitizers based on nanostructured forms of phthalocyanine derivatives

Influence of vesicle size distribution on level and selectivity of accumulation of liposomal photosensitizer Tiosens in tumor

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