&lt;title&gt;Autofluorescence diagnostic of gynecological diseases ex vivo&lt;/title&gt;

Zuev, V.M.; Beliaeva, Ludmila A.; Tevlina, E.V. Tevlina; Zaiceva, Galina U.; Loschenov, Victor B.; Stratonnikov, Alexander A.; Volkova, Anna I.

doi:10.1117/12.413720

Cited by 1 publication

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“…Thus the fluorescence spectroscopy diagnosis has drawn more and more attentions for its high sensitivity and specificity. There have been a mass of researches in the tissue auto-fluorescence spectroscopy diagnosis; some of them have acquired certain achievements [6][7][8].Ovarian histology has the potential developing possibility. The special location of ovary makes it very similar to the urinary system when the embryo generating and parts of the mesonephric kidney tissue may come into the ovary.…”

Section: Introductionmentioning

confidence: 99%

Study on characteristic intrinsic fluorescence spectra of urine from ovarian cancer patients

Gao

Yang

et al. 2007

SPIE Proceedings

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Ovarian cancer has the highest mortality rate among the gynecologic cancers, and it goes undetected because adequate technology does not exist to detect preinvasive or early stage disease. Fluorescence spectroscopy of urine may provide a cost-effective tool to improve precancer detection. This study describes initial investigation of the potential of intrinsic urine fluorescence spectra for detecting early ovarian cancer.Using the Xenon arc lamp to irradiate the urine from ovarian cancer, cervical carcinoma groups and healthy donors, we obtained fluorescence emission spectra. The three groups of samples show different emission spectra peak and fluorescence intensity. Ovarian cancer group has the largest displacement of maximum spectra peak at 380-400nm excitation wavelength. And the fluorescence intensity from ovarian cancer group is significantly higher with the healthy donors and cervical carcinoma group in comparison at the short wave excitation region of 320-360nm, while cervical carcinoma group has higher fluorescence intensity than ovarian cancer group at 380-500nm excitation. Characteristic fluorescence mechanism was studied through comparison of fluorescence spectra and software fitting image. Fluorescence spectra at 440nm excitation is found to be perfectly lorentzian fitted by three characteristic fluorescence peaks, which are originated form coproporphyrin, riboflavin and p-hydroxyphenol derivatives existing in the urine.

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Section: Introductionmentioning

confidence: 99%