&lt;title&gt;Combined SPECT and x-ray CT medical imaging system&lt;/title&gt;

Kalki, K.; Brown, J.K.; Blankespoor, S.C.; Heanue, Joseph A.; Wu, Xiang; Cann, Christopher E.; Hasegawa, B.H.; Chin, Michael C.; Stillson, Carol; Dae, Michael W.; Carver, James

doi:10.1117/12.208355

Cited by 10 publications

(3 citation statements)

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“…A prototype system (Figure 3a) included a collimated array of high-purity germanium (HPGe) detectors [47,48] to record photons from both the external x-ray source and the internal radionuclide distribution that then were processed with photon-counting electronics to discriminate the x-ray data (eg produced at 120 kV) and the radionuclide data (eg emitted at 140 keV for 99m Tc). An image (Figure 3b) of a pig administered a myocardial perfusion agent ( 99m Tc-sestamibi) shows radiopharmaceutical uptake in the myocardium displayed in red superimposed on in the grayscale CT image of the animal [49,50]. The development of the UCSF emissiontransmission CT system demonstrated the technical feasibility of acquiring the x-ray and radionuclide image data simultaneously using an HPGe detector array with highperformance photon-counting electronics.…”

Section: Early Development Of Spect/ctmentioning

confidence: 99%

Technological Development and Advances in Single-Photon Emission Computed Tomography/Computed Tomography

Seo

Marì

Hasegawa

2008

Seminars in Nuclear Medicine

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172

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SPECT/CT has emerged over the past decade as a means of correlating anatomical information from CT with functional information from SPECT. The integration of SPECT and CT in a single imaging device facilitates anatomical localization of the radiopharmaceutical to differentiate physiological uptake from that associated with disease and patient-specific attenuation correction to improve the visual quality and quantitative accuracy of the SPECT image. The first clinically available SPECT/CT systems performed emission-transmission imaging using a dual-headed SPECT camera and a low-power x-ray CT sub-system. Newer SPECT/CT systems are available with high-power CT sub-systems suitable for detailed anatomical diagnosis, including CT coronary angiography and coronary calcification that can be correlated with myocardial perfusion measurements. The high-performance CT capabilities also offer the potential to improve compensation of partial volume errors for more accurate quantitation of radionuclide measurement of myocardial blood flow and other physiological processes and for radiation dosimetry for radionuclide therapy. In addition, new SPECT technologies are being developed that significantly improve the detection efficiency and spatial resolution for radionuclide imaging of small organs including the heart, brain, and breast, and therefore may provide new capabilities for SPECT/CT imaging in these important clinical applications.

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Section: Early Development Of Spect/ctmentioning

confidence: 99%

Technological Development and Advances in Single-Photon Emission Computed Tomography/Computed Tomography

Seo

Marì

Hasegawa

2008

Seminars in Nuclear Medicine

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172

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“…The system used a segmented high-purity germanium (HPGe) detector operated in a fast photon-counting mode 34 with sufficient energy resolution to discriminate x-ray photons from an external source (for computed tomography) from emission γ-rays from an internal radionuclide source. The system was used for imaging studies in phantoms and in animals with 99m Tc-sestamibi in a porcine model of myocardial perfusion 15,16,35,36 .…”

Section: Spect/ct Imaging Systemsmentioning

confidence: 99%

Dual-modality imaging of function and physiology

Hasegawa¹,

Iwata²,

Wong³

et al. 2002

SPIE Proceedings

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Dual-modality imaging is a technique where computed tomography or magnetic resonance imaging is combined with positron emission tomography or single-photon computed tomography to acquire structural and functional images with an integrated system. The data are acquired during a single procedure with the patient on a table viewed by both detectors to facilitate correlation between the structural and function images. The resulting data can be useful for localization for more specific diagnosis of disease. In addition, the anatomical information can be used to compensate the correlated radionuclide data for physical perturbations such as photon attenuation, scatter radiation, and partial volume errors. Thus, dual-modality imaging provides a priori information that can be used to improve both the visual quality and the quantitative accuracy of the radionuclide images. Dual-modality imaging systems also are being developed for biological research that involves small animals. The small-animal dual-modality systems offer advantages for measurements that currently are performed invasively using autoradiography and tissue sampling. By acquiring the required data noninvasively, dual-modality imaging has the potential to allow serial studies in a single animal, to perform measurements with fewer animals, and to improve the statistical quality of the data.

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“…Phantom experiments with this first prototype led to the development of a second prototype (Figure 3) having a 20-cm reconstruction diameter that could record emission and transmission data from stationary animal or object using a single HPGe detector array. Kalki et al 59,60 used this second prototype in animal studies both to demonstrate the capability of the system to facilitate image correlation and to test the feasibility of correcting the Figure 2. Schematic of data acquisition of combined emission-transmission imaging system developed at UCSF using single high-purity germanium detector array with fast pulse-counting electronics for simultaneous emission-transmission imaging.…”

Section: Brief History Of Dual-modality Imagingmentioning

confidence: 99%