&lt;title&gt;CT-Images As The Basis Of Operation Planning In Stereotactical Neurosurgery&lt;/title&gt;

Schlegel, Wolfgang; Scharfenberǵ, H.; Doll, Josh R; Pastyr, O.; Sturm, Volker; Netzeband, G.; Lorenz, Walter J.

doi:10.1117/12.934621

Cited by 13 publications

(3 citation statements)

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“…Treatment planning for interstitial irradiation was performed with special computer programmes (Bauer etal. 1984, Schlegel et al 1982. Stereotactic CT image data, collected by a Somatom DR H (Siemens) were stored in a VAX 11/780 computer (Digital Equipment Corp.), and the tumour borders were subsequently outlined by manual control at the computer screen.…”

Section: Methodsmentioning

confidence: 99%

Incidence of late radiation necrosis with transient mass effect after interstitial low dose rate radiotherapy for cerebral gliomas

1989

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Late radiation necroses constitute a hazard in low dose rate interstitial irradiation for inoperable gliomas. An incidence of 40% (8/20 patients) was found after permanent implantation of Iodine-125 seeds. This finding may even underestimate the real frequency, because follow-up of unaffected patients was shorter than in patients with radiation necrosis. The necrotic reactions caused a transient mass effect, which lead to a significant deterioration of performance scores. Further manifestations of late delayed radiation damage were observed in two patients. The occurrence of radiation necrosis was correlated with total radiation dose, amount of implanted radioactivity, and with velocity of tumour shrinkage. A mechanism underlying the development of radiation necrosis is proposed: A rapid shrinkage of tumour after interstitial Iodine-125 implantation may cause a significant irradiation of surrounding brain tissue, which was initially lying outside the target volume. Since most patients affected by radiation necrosis were children or adolescents, the risk of radiation damage should be minimized. This could probably be achieved either by reduction of irradiation dose, or by using temporary implants of Iodine-125.

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Section: Methodsmentioning

confidence: 99%

Incidence of late radiation necrosis with transient mass effect after interstitial low dose rate radiotherapy for cerebral gliomas

1989

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“…The use of this method is recommended if the size of the ST device is larger than the gantry of the CT scanner or if the spatial synchronization of the two coordinate systems cannot be achieved for other reasons [1,5,6,7,15,16].…”

Section: Introductionmentioning

confidence: 99%

“…The indirect methods [1,5,6,7,15,16], 2. the direct methods [4,8,10,11,13], 3. the ex-post methods [3].…”

Section: Introductionmentioning

confidence: 99%