<title>Development and clinical evaluation of noninvasive near-infrared monitoring of cerebral oxygenation</title>

Abstract

Near infrared spectroscopy (NIRS) is a relatively new method which is suitable for monitoring oxygenation in blood and tissue in the brain of the fetus and the neonate. The technique involves in vivo determination of the absorption of light in the wavelength range 775 to 900nm through such tissue and converting such changes in absorbance to provide information about the changes in the concentration of oxygenated and de-oxygenated haemoglobin (Hb02 and Hb). Recent developments of the methodology now enable the calculation of changes in cerebral blood volume (CBV) as well as absolute CBV and cerebral blood flow (CBF). The attraction of this method is it's applicability to monitor cerebral function in wide variety of patient groups. Although primarily developed for neontal use it is today applied on the fetus to investigate fetal hypoxia and on adults undergoing surgery.

Hemodynamic and electrophysiological signals of conflict processing in the Chinese-character Stroop task: a simultaneous near-infrared spectroscopy and event-related potential study

“…25,28 One method, known as continuous-wave NIRS ͑CW-NIRS͒, does not require strict motion restriction and is thus well suited to studying children and the elderly. 29 Moreover, the CW-NIRS system is portable and inexpensive 30 and may potentially be coupled with ERP. 31,32 Thus, CW-NIRS is a promising technique with many possible clinical applications.…”

The MOST - Monitor for Oxygenation of Surface and Tissue.

“…This can allow for measurement of cytochrome aa3 oxidation using similar optical methods. Wickramasinghe et al (1994) describe a three wavelength system for measurement of HbO 2 , Hb, and cyt aa 3 .…”