&lt;title&gt;Different pathways of tumor damage due to PDT: the influence of parameters of laser irradiation&lt;/title&gt;

Meerovich, Gennadii A.; Stratonnikov, Alexander A.; Loschenov, Victor B.; Kogan, E. A.; Gladskikh, Olga P.; Лукьянец, Е. А.; Vorozhtsov, Georgy N.; Pal'tsev, M A

doi:10.1117/12.413726

Cited by 2 publications

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“…This effect was demonstrated in the study of blood deoxygenation in the microcirculation flow during PDT [11] and also confirmed by the results of more recent pathomorphological investigations [7].…”

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confidence: 72%

“…The results of pathomorphological investigations [7] showed that the direct photodynamic effect of Photosense on the cells and tissues of parenchyma was more pronounced when the period of time between the photosensitizer administration and irradiation exceeds 24 h. The active components of Photosense have various degrees of sulfonation and, hence, differently penetrate through vessel walls and influence the parenchyma [8,9]. The amphiphilic character of the photosensitizer also significantly influences the ability of Photosense to penetrate through the membranes of tumor cells.…”

mentioning

confidence: 99%

“…Previous investigations into the mechanisms of the photodynamic damage of inoculated tumors by Photosense showed that the therapeutic activity of this drug is a multifactor process including (i) necrosis and apoptosis of tumor cells under the direct action of cytotoxic agents (singlet oxygen, free radicals) generated in the course of PDT and (ii) ischemic necrosis caused by the violated blood flow in vessels of the tumor [7]. The results of pathomorphological investigations [7] showed that the direct photodynamic effect of Photosense on the cells and tissues of parenchyma was more pronounced when the period of time between the photosensitizer administration and irradiation exceeds 24 h. The active components of Photosense have various degrees of sulfonation and, hence, differently penetrate through vessel walls and influence the parenchyma [8,9].…”

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Efficiency and Pharmacokinetics of Photosense: A New Liposomal Photosensitizer Formulation Based on Aluminum Sulfophthalocyanine

et al. 2005

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The photodynamic activity and pharmacokinetics of a new liposomal form (LF) of the sensitizer Photosense based on aluminum sulfophthalocyanine salts have been studied in comparison to those of the standard form (SF) representing a 0.2% aqueous solution of the parent substance. The effective therapeutic doze of the LF of Photosense in mice bearing Ehrlich's tumor was 1 mg/kg, which is four times as small as the effective dose of the SF. The selectivity of accumulation in the tumor tissue 24 h after administration for the LF of Photosense was 1.5 times higher than for the SF. The drug accumulation in skin (determined by the fluorescence intensity) on the 7th days of experiment for the LF of Photosense was 1.6 times lower than for the SF. The pharmacokinetics of the LF of Photosense in mice without tumors significantly differs from the behavior of the SF.In recent years, the photodynamic therapy (PDT) and fluorescent diagnostics (FLD) of neoplasms have been extensively developed both in the experimental oncology and on the clinical level. In Russia, several potential photosensitizers for PDT and FLD are currently under clinical investigation [1 -4]. Among these, most thoroughly studied is Photosense -a domestic photosensitizer of the second generation -representing a mixture of sodium salts of sulfonated aluminum phthalocyanine, which is synthesized using an original patented technology developed at the State Research Institute of Organic Semiproducts and Dyes (Moscow) [5,6].Previous investigations into the mechanisms of the photodynamic damage of inoculated tumors by Photosense showed that the therapeutic activity of this drug is a multifactor process including (i) necrosis and apoptosis of tumor cells under the direct action of cytotoxic agents (singlet oxygen, free radicals) generated in the course of PDT and (ii) ischemic necrosis caused by the violated blood flow in vessels of the tumor [7]. The results of pathomorphological investigations [7] showed that the direct photodynamic effect of Photosense on the cells and tissues of parenchyma was more pronounced when the period of time between the photosensitizer administration and irradiation exceeds 24 h. The active components of Photosense have various degrees of sulfonation and, hence, differently penetrate through vessel walls and influence the parenchyma [8,9]. The amphiphilic character of the photosensitizer also significantly influences the ability of Photosense to penetrate through the membranes of tumor cells. The attachment of two biotin residues to the molecule of Photosense provided for nearly optimum amphiphilic properties and significantly increased the efficacy of the drug action [10].

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Efficiency and Pharmacokinetics of Photosense: A New Liposomal Photosensitizer Formulation Based on Aluminum Sulfophthalocyanine

et al. 2005

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“…Фотодинамическое воздействие на опухоль является комплексным вследствие интеграции множественных противоопухолевых ответов. В ряде исследований [3][4][5] показано, что фотодинамическое воздействие может оказывать как прямое (непосредственное) воздействие на клетки опухоли, вызывая их некроз и апоптоз, так и опосредованное, приводя к нарушению кровотока в сосудах и капиллярах опухоли и вызывая их тромбоз или приводя к геморрагиям. Доминирование того или иного механизма действия связано со свойствами ФС и в значительной мере зависит от режима облучения и временного интервала между внутривенным (в/в) введением ФС и началом облучения.…”

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Study of level and selectivity of liposomal form of photosensitiser hydroxyaluminium tetra-3-phenylthiophthalocyanine accumulation on transplantable mice tumor models at different ways of transplantation

Meerovich

Борисова²,

Будько³

et al. 2017

Rossijskij bioterapevtičeskij žurnal

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Background. Current work is devoted to the study in vivo of concentration and selectivity of accumulation of infrared photosensitizer (PS) hydroxyaluminium tetra-3-phenylthiophthalocyanine in liposomal form in intramuscularly and subcutaneously transplanted mice tumor models in comparison to normal tissues. Objective: to study the level and selectivity of accumulation of hydroxyaluminium tetra-3-phenylthiophthalocyanine liposomal form on mice tumor models in order to optimize the transplantation approach and the starting of photodynamic treatment. Materials and methods. A range of transplantable mice tumors was used in the study: solid carcinoma Ehrlich (ELD) and solid sarcoma S-37, epidermoid Lewis lung carcinoma (LLC) and colon adenocarcinoma (AKATOL). For the assessment of concentration of PS in tissues was evaluated by fluorescence spectroscopy in vivo. Results. The optimum transplantation approaches were shown to be as follows. Solid carcinoma Ehrlich (ELD) provided the highest accumulation of PS when transplanted intramuscularly. Five hours after administration concentration of PS in tumor achieves more than 7 mg/kg, with selectivity in comparison to normal tissue 3 : 1. The maximum concentration of PS in sarcoma S-37 was observed with subcutaneous transplantation, achieving at 5 h after administration the value of 5.4 mg/kg with selectivity of accumulation 4.3: 1. Both LLC and AKATOL showed optimum results with intramuscular transplantation. Maximum concentration of PS in LLC was observed 5 h after administration, achieving 7.5 mg/kg with selectivity exceeding 4. Concentration of photosensitizer in AKATOL 7h post administration achieved 6.8 mg/kg with selectivity about 2. Conclusions. Liposomal form of PS with intravenous administration selectively accumulates in tumors. The obtained experimental data allows to recommend the method of listed tumors models transplantation for the studies of PS.

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<title>Different pathways of tumor damage due to PDT: the influence of parameters of laser irradiation</title>

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Efficiency and Pharmacokinetics of Photosense: A New Liposomal Photosensitizer Formulation Based on Aluminum Sulfophthalocyanine

Efficiency and Pharmacokinetics of Photosense: A New Liposomal Photosensitizer Formulation Based on Aluminum Sulfophthalocyanine

Study of level and selectivity of liposomal form of photosensitiser hydroxyaluminium tetra-3-phenylthiophthalocyanine accumulation on transplantable mice tumor models at different ways of transplantation

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