The Astrobiology Space Infrared Explorer (ASPIRE) is a Probe-class mission concept developed as part of NASA's Astrophysics Strategic Mission Concept studies. 1 2 ASPIRE uses infrared spectroscopy to explore the identity, abundance, and distribution of molecules, particularly those of astrobiological importance throughout the Universe. ASPIRE's observational program is focused on investigating the evolution of ices and organics in all phases of the lifecycle of carbon in the universe, from stellar birth through stellar death while also addressing the role of silicates and gas-phase materials in interstellar organic chemistry. ASPIRE achieves these goals using a Spitzer-derived, cryogenically-cooled, 1-m-class telescope in an Earth drift-away heliocentric orbit, armed with a suite of infrared spectrometers operating in the 2.5-36 micron wavelength region supported by a Kepler-based spacecraft bus. This paper summarizes the results of the ASPIRE Origins Probe Mission Concept Study while focusing on its high heritage mission implementation.