&lt;title&gt;Feasibility of using diffuse reflectance spectroscopy for the quantification of brain edema&lt;/title&gt;

Rodriguez, Juan G.; Sisson, Cynthia; Hendricks, C.; Pattillo, Chris; McWaters, M.; Hardjasudarma, Mardjohan; Quarles, C. Chad; Yaroslavsky, Anna N.; Yaroslavsky, Ilya V.; Battarbee, Harold D.

doi:10.1117/12.431509

Cited by 3 publications

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“…Several optical imaging techniques have been used so far to detect these optical alterations during cerebral edema with various advantages and disadvantades. [3][4][5][6] However, none of them has been able to separate light absorption from scattering and to provide absolute quantitative spectroscopic maps in a non-contact manner. These deficiencies motivated us to propose an alternative non-contact and simple free-scan setup based on spatial light modulation 7 to detect and map tissue chromophore changes in the brain during cerebral edema.…”

Section: Introductionmentioning

confidence: 99%

Using NIR spatial illumination for detection and mapping chromophore changes during cerebral edema

et al. 2008

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We used spatially-modulated near-infrared (NIR) light to detect and map chromophore changes during cerebral edema in the rat neocortex. Cerebral edema was induced by intraperitoneal injections of free water (35% of body weight). Intracranial pressure (ICP) was measured with an optical fiber based Fabry-Perot interferometer sensor inserted into the parenchyma of the right frontal lobe during water administration. Increase in ICP from a baseline value of 10 cm-water to 145 cm-water was observed. Following induction of cerebral edema, there was a 26±1.7% increase in tissue concentration of deoxyhemoglobin and a 47±4.7%, 17±3% and 37±3.7% decrease in oxyhemoglobin, total hemoglobin concentration and cerebral tissue oxygen saturation levels, respectively. To the best of our knowledge, this is the first report describing the use of NIR spatial modulation of light for detecting and mapping changes in tissue concentrations of physiologic chromophores over time in response to cerebral edema.

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Section: Introductionmentioning

confidence: 99%

Using NIR spatial illumination for detection and mapping chromophore changes during cerebral edema

et al. 2008

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Experimental assessment of the CSF contribution to light propagation in the adult head

Rodriguez

Sisson

Pattillo

et al. 2001

Technical Digest. Summaries of Papers Presented at the Conference on Lasers and Electro-Optics. Postconference Technical Digest

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Monitoring hemodynamic and morphologic responses to closed head injury in a mouse model using orthogonal diffuse near-infrared light reflectance spectroscopy

2013

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The authors' aim is to assess and quantitatively measure brain hemodynamic and morphological variations during closed-head injury (CHI) in mice using orthogonal diffuse near-infrared reflectance spectroscopy (o-DRS). CHI is a type of injury to the head that does not penetrate the skull. Usually, it is caused by mechanical blows to the head and frequently occurs in traffic accidents, falls, and assaults. Measurements of brain optical properties, namely absorption and reduced scattering coefficients in the wavelength range from 650 to 1000 nm were carried out by employing different source-detector distance and locations to provide depth sensitivity on an intact scalp over the duration of the whole experiment. Furthermore, alteration in both cortical hemodynamics and morphologic markers, i.e., scattering power and amplitude properties were derived. CHI was induced in anesthetized male mice by a weight-drop model using ∼50 g cylindrical metal falling from a height of 90 cm onto the intact scalp producing an impact of 4500 g cm. With respect to baseline, difference in brain physiological properties was observed following injury up to 1 h post-trauma. Additionally, the reduced scattering spectral shapes followed Mie scattering theory was quantified and clearly shows changes in both scattering amplitude and power from baseline indicating structural variations likely from evolving cerebral edema during CHI. We further demonstrate high correlation between scattering amplitude and scattering power, with more than 20% difference in slope in comparison to preinjury. This result indicates the possibility of using the slope also as a marker for detection of structural changes. Finally, experiments investigating brain function during the first 20 min postinjury were conducted and changes in chromophore concentrations and scattering were observed. Overall, our experiments demonstrate the potential of using the proposed technique as a valuable quantitative noninvasive tool for monitoring brain physiology following CHI injury at the bedside and/or at the field.

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<title>Feasibility of using diffuse reflectance spectroscopy for the quantification of brain edema</title>

Cited by 3 publications

References 0 publications

Using NIR spatial illumination for detection and mapping chromophore changes during cerebral edema

Using NIR spatial illumination for detection and mapping chromophore changes during cerebral edema

Experimental assessment of the CSF contribution to light propagation in the adult head

Monitoring hemodynamic and morphologic responses to closed head injury in a mouse model using orthogonal diffuse near-infrared light reflectance spectroscopy

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