<title>Free-electron laser effects on fibrin tissue glue: a preliminary study</title>

Abstract

One glaucoma challenge is the treatment of leaking trabeculectomy blebs. Simple methods such as patching, autologous blood injection, compression sutures or cyanoacrylate glue application often fail. Because the conjunctiva is thin and ischemic, it often can't be sutured together so major surgery is required to excise the thin tissue and advance healthy conjunctiva. We report the preliminary results of Tisseel and Tisseel treated with two wavelengths from Vanderbilt's free electron laser placed on leaking trabeculectomy bleb holes in Dutch belted rabbits. The holes were healed at one week in the sutured group and in the 7.7 tm FEL-treated Tisseel group. One hole was healed in the cyanoacrylate gluetreated group. Holes remained in the other treatment groups. Tisseel irradiated with 7.7 tm energy from the free electron laser may promote healing oftrabeculectomy bleb holes.