&lt;title&gt;High sensitive pulse oximeter-spectrophotometer for laser-optical dosimetry in biology and medicine&lt;/title&gt;

Asimov, M. M.; Asimov, R. M.; Рубинов, А. Н.; Mamilov, S. A.; Plaksiy, Yu. S.

doi:10.1117/12.677684

Cited by 4 publications

(3 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It should be noted that in order to reach experimentally observed the rise of ТсРО 2 by 1, 6 times at the surface of tissue, the calculation indicates the increase of oxygen release rate from arterial HbO 2 into blood plasma should increase about 4,3 times. Photodissociation of HbO 2 induced by laser radiation and release rate of free molecular oxygen into blood plasma has been measured experimentally in vivo using high sensitive pulse oxymeter 14 . The oxygen released from HbO 2 primarily increases the PO 2 of blood plasma and then O 2 diffuses into a tissue.…”

Section: Resultsmentioning

confidence: 99%

“…The efficiency of the interaction of laser radiation on oxyhemoglobin of blood vessels in different wavelengths and layers of tissue is studied. The mathematical model of laser-tissue interaction developed that allows finds the optimal parameters to induce an effective photodissociation of hemoglobin complexes in cutaneous blood vessels 13,14 . The temperature dependence of the quantum yield of photodissociation of HbO 2 observed earlier in vitro is proved experimentally in vivo.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

<title>Investigation of tissue oxygenation by in vivo laser-induced photodissociation of cutaneous arterial blood oxyhemoglobin</title>

Asimov

Korolevich²

2008

SPIE Proceedings

Self Cite

View full text Add to dashboard Cite

A novel method of direct control of local tissue oxygenation based on laser-induced photodissociation of oxyhemoglobin in cutaneous blood vessels is discussed. New technology in selective and local increase of the concentration of free molecular oxygen in tissue that enhances metabolism of cells is demonstrated. Direct in vivo measurements of the tissue oxygen tension are carried out on human skin. Kinetics of oxygen tension in tissue is investigated under the effect of HeNe laser radiation at the power of 1mW relatively to initial value of tissue oxygen tension. The results of experimental study the kinetics of oxygen distribution into tissue from arterial blood is presented. Biomedical applications of proposed new technology in laser therapy of pathologies where elimination of local tissue hypoxia is critical are discussed.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<title>Investigation of tissue oxygenation by in vivo laser-induced photodissociation of cutaneous arterial blood oxyhemoglobin</title>

Asimov

Korolevich²

2008

SPIE Proceedings

Self Cite

View full text Add to dashboard Cite

show abstract

“…Experimental setup for measuring changes of the relative concentration of oxyhemoglobin in arterial blood (saturation of arterial blood with oxygen), that being decisive for normal human life activities, is a pulse oximeter-spectrophotometer developed in the Institute of Applied Problems of Physics and Biophysics of NAS of Ukraine [5]. A sensor operating in transmitted and back-scattered light based on a standard pair of pulse-oximetry Light emitted diodes (LEDs) V97B (λmax = 660 nm and 940 nm) and a silicon photodiode BPW34 was used in experiments.…”

Section: Methodsmentioning

confidence: 99%

Arterial Blood Oxygen Saturation and Its Dynamics Due to the Environmental Electromagnetic Conditions

Mamilov¹,

Gorgo²,

Esman³

et al. 2019

Innov Biosyst Bioeng

View full text Add to dashboard Cite

Background. As widely known, the geomagnetic field intensity does change abruptly during global magnetic disturbances specified as magnetic storms. Those are due to the changing solar activity influencing solar wind parameters and the state of the magnetosphere. This chain of physical processes with their origin in the Sun is described as the space weather. To understand the space weather effects in the environment is most important since those are related to the biosphere as well. Namely, the low-frequency geomagnetic field dynamics, linked with space weather conditions, seems to be a quite probable factor influencing both the pathological and functional state of a human being and biological objects, in general, during magnetic storms. Objective. In this study, the dynamics of an oxygen saturation parameter in human arterial blood is analyzed with regard to extreme space weather when magnetic storms occur. Methods. Experimental setup for measuring changes of the relative concentration of oxyhemoglobin in arterial blood (saturation of arterial blood with oxygen), is a pulse oximeter-spectrophotometer. Measurements were carried out using pulse-oximetry sensor covering the first phalanx of a finger, and laser radiation was directed to the side of the second phalanx. The He-Ne laser with a wavelength of 632 nm was used as a source of electromagnetic radiation. Observational values of the geomagnetic field with a high-time resolution (1-sec) are obtained from the midlatitude Hurbanovo Geomagnetic Observatory (Slovak Republic). Deviations/oscillation ranges regarding the average value were calculated at all frequencies, and low pass filter was applied from the "Seewave-1.7.6" package (F-filter) for frequencies of 0.1, 0.5, 0.01, 0.05, 0.001, and 0.0001 Hz. The data on magnetic storms for 2015 were derived from the file of Kyoto Geomagnetic Center which indicated the dates and the amplitudes of magnetic storms on the Earth. Results. The following variables were analyzed: the average arterial oxygen saturation at the patient's rest, peak-to-peak value of saturation, changes in the average oxygen saturation under laser radiation. A group of 33 persons was daily monitored from March 30, 2015, to May 25, 2015. In the presence of Earth's magnetic field disturbances, the average value of arterial oxygen saturation at the state of rest in 29 persons out of 33 was 93.9 ± 0.9%, peak-to-peak value of oxygen was 1.25 ± 0.24%, and the change in the average arterial oxygen saturation under laser radiation made up 2.34 ± 0.41%. In 4 persons under study the peak-to-peak value of saturation at rest did not differ from the case of the undisturbed geomagnetic field. Conclusions. The results of this study of some blood parameters, namely the oxygen saturation (and oxygenetion) value of the arterial blood and its dynamics due to exposed laser radiation in case of both the undisturbed and disturbed GMF, can be summarized as follows: the decrease of the blood oxygenation in case of the disturbed GMF (magnetic storm conditions) is quite appa...

show abstract

Investigation of the photodissociation quantum efficiency of hemoglobin derivatives

Mamilov¹,

Yesman²,

Velyhotskyi³

2019

2019 IEEE 39th International Conference on Electronics and Nanotechnology (ELNANO)

View full text Add to dashboard Cite

<title>High sensitive pulse oximeter-spectrophotometer for laser-optical dosimetry in biology and medicine</title>

Cited by 4 publications

References 2 publications

<title>Investigation of tissue oxygenation by in vivo laser-induced photodissociation of cutaneous arterial blood oxyhemoglobin</title>

<title>Investigation of tissue oxygenation by in vivo laser-induced photodissociation of cutaneous arterial blood oxyhemoglobin</title>

Arterial Blood Oxygen Saturation and Its Dynamics Due to the Environmental Electromagnetic Conditions

Investigation of the photodissociation quantum efficiency of hemoglobin derivatives

Contact Info

Product

Resources

About