We outline a concept for OWL-Moon, a 50-100m aperture telescope located on the surface of the Moon, to address three major areas in astronomy, namely the detection of biosignatures on habitable exoplanets, the geophysics of exoplanets, and cosmology. Such a large lunar telescope, when coupled with large Earth-based telescopes, would allow Intensity Interferometric measurements, leading to picoarcsecond angular resolution. This would have applications in many areas of astronomy and is timely in light of the renewed interest of space agencies in returning to the Moon.