<title>New sensitizers for PDT</title>

Metal Complexes as Photo- and Radiosensitizers

“…The shift is more pronounced in the case of an amino substituent, i.e., 202f has a λ max at 710 nm compared to the tert -amylthio analogue 202g at 649 nm , Coordination of Zn 2+ in the center cavity results in little change in the biological activity, but attachment of both long aliphatic chains or cyclic amines and cyano groups in the periphery of the porphyrazines causes a loss in activity. Also, the removal of the cyano moiety has a negative effect on the photodynamic efficacy of the compounds.…”

“…The shift is more pronounced in the case of an amino substituent, i.e., 202f has a λ max at 710 nm compared to the tert-amylthio analogue 202g at 649 nm. 262 Evaluation of the series 202a-h for their ability to photoinactivate V-79 Chinese hamster fibroblasts in vitro showed that the N,N-diethylamino 202f has the highest PDT potential. 260,262 Coordination of Zn 2+ in the center cavity results in little change in the biological activity, but attachment of both long aliphatic chains or cyclic amines and cyano groups in the periphery of the porphyrazines causes a loss in activity.…”

“…262 Evaluation of the series 202a-h for their ability to photoinactivate V-79 Chinese hamster fibroblasts in vitro showed that the N,N-diethylamino 202f has the highest PDT potential. 260,262 Coordination of Zn 2+ in the center cavity results in little change in the biological activity, but attachment of both long aliphatic chains or cyclic amines and cyano groups in the periphery of the porphyrazines causes a loss in activity. Also, the removal of the cyano moiety has a negative effect on the photodynamic efficacy of the compounds.…”