&lt;title&gt;Optical computer-assisted tomography realized by coherent detection imaging incorporating laser heterodyne method for biomedical applications&lt;/title&gt;

Inaba, Humio; Toida, Masahiro; Ichimura, Teijiro

doi:10.1117/12.26105

Cited by 25 publications

(6 citation statements)

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“…Since only the coherent portion interferes with the reference beam, the isolated beat frequency has an amplitude proportional to its intensity. Heterodyne systems based on the Mach-Zehnder interferometer have been demonstrated by several investigators, and sensitivities in excess of 100 dB have been achieved (Inaba et al 1990, Hee et al 1993a, b, Schmidt et al 1995. Probably the first demonstration of tissue imaging using heterodyne detection was described by Inaba et al (1990), who used a computed tomography system to obtain a cross-sectional image of chicken tissue.…”

Section: Heterodyne Detectionmentioning

confidence: 99%

“…Heterodyne systems based on the Mach-Zehnder interferometer have been demonstrated by several investigators, and sensitivities in excess of 100 dB have been achieved (Inaba et al 1990, Hee et al 1993a, b, Schmidt et al 1995. Probably the first demonstration of tissue imaging using heterodyne detection was described by Inaba et al (1990), who used a computed tomography system to obtain a cross-sectional image of chicken tissue. This system was later used to obtain images of a new-born mouse head, approximately 1 cm diameter (Inaba 1993).…”

Section: Heterodyne Detectionmentioning

confidence: 99%

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Optical imaging in medicine: I. Experimental techniques

1997

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The overwhelming scatter which occurs when optical radiation propagates through tissue severely limits the ability to image internal structure using measurements of transmitted intensity. A broad range of methods has been proposed during the past decade or so in order to improve imaging performance. Direct methods involve isolating an unscattered or least-scattered component of transmitted scattered light. Indirect methods generally involve measuring some characteristic of the temporal distribution of transmitted light, or an equivalent in the frequency domain, and obtaining a computational solution to the inverse problem. In this paper, we review the experimental techniques which have been proposed in order to explore both direct and indirect imaging. The relative merits and limitations of the various experimental methods are discussed, and we consider the future directions and likelihood of success of optical imaging in medicine.

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Section: Heterodyne Detectionmentioning

confidence: 99%

Section: Heterodyne Detectionmentioning

confidence: 99%

Optical imaging in medicine: I. Experimental techniques

1997

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“…• Heterodyne detection [Inaba 1990]. The scattered light is interferometrically combined with a frequency modulated reference beam.…”

Section: Isolating Shorter Flight Time Photonsmentioning

confidence: 99%

Development of a time‐resolved optical tomography system for neonatal brain imaging

Schmidt

2000

Medical Physics

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Articles you may be interested in MONSTIR II: A 32-channel, multispectral, time-resolved optical tomography system for neonatal brain imaging Rev. Sci. Instrum. 85, 053105 (2014); 10.1063/1.4875593 A multi-view time-domain non-contact diffuse optical tomography scanner with dual wavelength detection for intrinsic and fluorescence small animal imaging Rev. Sci. Instrum. 83, 063703 (2012);Time-correlated single photon counting imager for simultaneous magnetic resonance and near-infrared mammography Rev.

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“…Originally, the CDI method based on the optical heterodyne detection technique for laser tomography of biological tissues in the transillumination mode was devised and realized by Inaba and co-workers [12]. They had demonstrated its effectiveness for biomedical imaging, and reported tomographic images of various biological samples both in vitro and in vivo [13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 98%

Finger joint imaging by laser transillumination computed tomography based on coherent detection imaging method

et al. 2003

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In this research, we investigate the imaging properties of tansillumination laser CT system based on the coherent detection imaging (CDI) method, for early diagnosis of rheumatoid arthritis, from the viewpoints of morphological and quantitative imaging. First, to investigate the morphological imaging ability, the index finger PIP joint of a healthy volunteer was imaged with the laser CT, X-ray CT, and MRI. By comparison of these images, we present that the laser CT delineates the bone region with high spatial resolution of sub-millimeters. Next, to investigate the quantitative imaging, three kinds of the physical phantoms simulating bone, made from polyurethane including different concentrations of CaCO 3 , were imaged. We present that quantitative measurement is possible by demonstrating a satisfactory linear relationship between the averaged pixel value of the reconstructed images and the actual concentrations. These results demonstrate the feasibility of early diagnosis for rheumatoid arthritis.

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<title>Optical computer-assisted tomography realized by coherent detection imaging incorporating laser heterodyne method for biomedical applications</title>

Cited by 25 publications

References 0 publications

Optical imaging in medicine: I. Experimental techniques

Optical imaging in medicine: I. Experimental techniques

Development of a time‐resolved optical tomography system for neonatal brain imaging

Finger joint imaging by laser transillumination computed tomography based on coherent detection imaging method

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