&lt;title&gt;RBC-aggregation-assisted light transmission through blood and occlusion oximetry&lt;/title&gt;

Fine, Ilya; Fikhte, B. A.; Shvartsman, L. D.

doi:10.1117/12.405932

Cited by 20 publications

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“…The volume and the shape of an individual erythrocyte are determined by the osmolality of the blood plasma [125,126]. The blood scattering is also dependent on the ability of the red blood cells to aggregate or disaggregate [127].…”

Section: Immersion Clearingmentioning

confidence: 99%

Optical clearing of biological tissues: prospects of application in medical diagnostics and phototherapy

Genina

Bashkatov

Sinichkin

et al. 2015

JBPE

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Abstract.A review of specific features and methods of optical clearing and related interaction of light with tissues is presented. Physical and molecular mechanisms of immersion, compression, and photodynamic/photothermal optical clearing of some fibrous and cellular tissues are discussed. The possibility of efficient control of the tissue optical properties, particularly, the reduction of light scattering in tissues is demonstrated, which facilitates the increased efficiency of various optical visualisation methods (optical biopsy) used in medical purposes. © 2015 Samara State Aerospace University (SSAU).Keywords: tissue, optical clearing, optical diagnostics, imaging. 1, 404-413 (1997). 5. C. L. Smithpeter, A. K. Dunn, A. J. Welch, and R. Richards-Kortum, "Penetration depth limits of in vivo confocal reflectance imaging," Appl. Opt. 37, 2749Opt. 37, -2754Opt. 37, (1998. 6. V. V. Tuchin, L. V. Wang, and D. A. Zimnyakov, Optical Polarization in Biomedical Applications, SpringerVerlag, New York, NY, USA (2006). 7. R. Drezek, A. Dunn, and R. Richards-Kortum, "Light scattering from cells: finite-difference time-domain simulations and goniometric measurements," Appl. Opt. 38(16), 3651-3661 (1999). 8. K. Sokolov, R. Drezek, K. Gossagee, and R. Richards-Kortum, "Reflectance spectroscopy with polarized light:is it sensitive to cellular and nuclear morphology," Opt. Express 5, 302-317 (1999). 9. D. W. Leonard, and K. M. Meek, "Refractive indices of the collagen fibrils and extrafibrillar material of the corneal stroma," Biophysical J. 72, 1382-1387 (1997). 10. A. G. Borovoi, E. I. Naats, and U. G. Oppel, "Scattering of light by a red blood cell," J. Biomed. Opt. 3, 364-372 (1998). 11. A. N. Yaroslavsky, A. V. Priezzhev, J. Rodriguez, I. V. Yaroslavsky, and H. Battarbee, "Optics of blood,"Chap. 2 in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, Ed., pp. 169-216, PM107 SPIE Press, Bellingham, WA, USA (2002). 12. G. Mazarevica, T. Freivalds, and A. Jurka, "Properties of erythrocyte light refraction in diabetic patients," J.Biomed. Opt. 7, 244-247 (2002). 13. M. Friebel, and M. Meinke, "Model function to calculate the refractive index of native hemoglobin in the wavelength range of 250-1100 nm dependent on concentration," Appl. Opt. 45(12), 2838-2842 (2006). Appl. Opt. 35(19), 3413-3420 (1996). 34. D. Zhu, J. Wang, Z. Zhi, X. Wen, and Q. Luo, "Imaging dermal blood flow through the intact rat skin with an optical clearing method," J. Biomed. Opt. 15, 026008 (2010 241. K. König, G. Flemming, and R. Hibst, "Laser-induced autofluorescence spectroscopy of dental caries lesion," Cell. Mol. Biol. 44, 1293-1300. 242. E. G. Borisova, T. T. Uzunov, and L. A. Avramov, "Early differentiation between caries and tooth demineralization using laser-induced autofluorescence spectroscopy," Lasers Surg. Med. 34, 249-253 (2004 -20(12), 1512-1516 (1984). 245. K. Konig, H. Schneckenburger, and R. Hibst, "Time-gated in vivo autofluorescence imaging of dental caries,"Cell. Mol. Biol. 45, 233-239 (1999). 246. E. Borisova, P. Tr...

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Section: Immersion Clearingmentioning

confidence: 99%

Optical clearing of biological tissues: prospects of application in medical diagnostics and phototherapy

Genina

Bashkatov

Sinichkin

et al. 2015

JBPE

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“…6 Red blood cells naturally aggregate to form semi-rigid networks in plasma. 22 Evidence of red blood cell aggregation is present within the time dependent response obtained from each measurement channel of the Kromoscopy experiment.…”

Section: Effect Of Glucose On Red Blood Cells Aggregationmentioning

confidence: 99%

“…[1][2][3] In addition, a glucose dependency has been reported for light scattering processes involving living dermal tissue [4][5] and whole blood. 6,7 This glucose dependent phenomenon is related to changes in the magnitude of the refractive index mismatch between extra-cellular fluid and cellular membranes. Furthermore, glucose is reported to alter the aggregation properties of erythocytes within the blood matrix, thereby affecting scatting properties.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, glucose is reported to alter the aggregation properties of erythocytes within the blood matrix, thereby affecting scatting properties. 6,7 The principal objective of the work reported here is to characterize and understand the glucose dependent transmission properties of whole blood in order to develop better spectroscopic methods for measuring glucose _______________ mark-arnold@uiowa.edu; phone:319 335 1368, fax: 319 353 1115, ostc.physics.uiowa.edu/~arg/index.html nondestructively and reagentlessly. Although the scattering properties of blood are both strong and dependent on glucose concentration, scattering information is non-specific in nature and can be affected by many components of the blood matrix.…”

Section: Introductionmentioning

confidence: 99%

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The influence of glucose upon the transport of light through the whole blood

2004

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Optical properties of whole bovine blood are examined under conditions of different glucose loadings. A strong dependency is established between the scattering properties of the whole blood matrix and the concentration of glucose. This dependency is explained in terms of variations in the refractive index mismatch between the scattering bodies (predominately red blood cells) and the surrounding plasma, and also by variations in the size and shape of the red blood cells. Measurements in the presence of a well-known glucose transport inhibitor indicate that variations in refractive index mismatch are related to the penetration of glucose into the red blood cells. In addition, results measure the glucose dependent aggregation properties of red blood cells. In this experiment, pulsations in transmitted light intensity are explained by cycles of aggregation and disaggregation of red blood cells in response to a propagating pump wave through the blood matrix. Magnitude of these pulsations depends on the concentration of glucose in the sample. Results are also presented to characterize the time-dependent variation in light transmission in response to a step change in glucose concentration. Finally, multivariate calibration models are presented for the measurement of glucose in a whole blood matrix. These models are based on near infrared spectra and Kromoscopy data collected from eighty different samples prepared from a single whole blood matrix. The best model is generated for combination near infrared spectra, which provides a standard error of prediction is less than 1 mM over a concentration range of 3 to 30 mM.

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“…Intercellular bridges constitute attractive interactions between RBC that causes formation of rouleaux. [8][9][10][11][12][13][14] The intensity of the light transmitted by a blood sample increases as a result of the rouleau formation. With time the rouleaux build a chaotic three-dimensional network.…”

Section: Introductionmentioning

confidence: 99%

Optical monitoring of complex dynamics of blood sedimentation and lymph flow in vessels

Tuchin

2004

SPIE Proceedings

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In this paper a few examples of the complex behavior of biological systems detected by optical techniques are described. All examples are related to cell suspensions behavior in in vitro and in vivo studies. In vitro studies performing investigation of a fine structure of blood sedimentation process and establishing nonlinear features of blood sedimentation as disease prognostic parameters are overviewed. Three optical techniques: OCT, CW laser beam transverse synchronized transillumination method and spatially-modulated laser beam transillumination method were considered. In blood sedimentation studied by OCT the regular or irregular oscillations of the RBC/plasma boundary were observed. The functional properties of erythrocytes in patients with coronary heart disease by mean of spatiallymodulated laser beam transillumination method to reveal the stages of the acute coronary syndrome formation are discussed. The laser speckle and intravital TV-microscopic techniques applied to in vivo studies of lymph flow in microvessels are overviewed. The hypothesis on the alternating-translation (shuttle-stream) character of lymph flow is discussed.

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<title>RBC-aggregation-assisted light transmission through blood and occlusion oximetry</title>

Cited by 20 publications

References 0 publications

Optical clearing of biological tissues: prospects of application in medical diagnostics and phototherapy

Optical clearing of biological tissues: prospects of application in medical diagnostics and phototherapy

The influence of glucose upon the transport of light through the whole blood

Optical monitoring of complex dynamics of blood sedimentation and lymph flow in vessels

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